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by ApropoE4
Sun Feb 16, 2020 3:02 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 7001

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

I thought this was presented in the original paper by Mahley and Huang. https://doi.org/10.1021/jm3008618 However, to date, the most potent phthalazinone apoE4SCs caused significant toxicity in mice. Therefore, we have expanded our validation studies to other apoE4SCs. A series of pyrazoline analogu...
by ApropoE4
Sun Feb 16, 2020 12:23 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 7001

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

I wouldn't give mice PH002 unless I want to kill them. (actually most of my interactions with mice involved killing them so that might not be a bad thing) The molecules in e-scape bio's queue and several others are supposedly functional analogs but without the toxic effects that I assume PH002 would...
by ApropoE4
Sat Feb 08, 2020 11:09 am
Forum: Science and Research
Topic: Phase 1 Gene Therapy Trial
Replies: 2
Views: 643

Re: Phase 1 Gene Therapy Trial

Ah, I see. It's in the announcements forum.

viewtopic.php?f=15&t=6620
by ApropoE4
Fri Feb 07, 2020 5:13 pm
Forum: Science and Research
Topic: Phase 1 Gene Therapy Trial
Replies: 2
Views: 643

Phase 1 Gene Therapy Trial

I'm not sure if it's been mentioned here, but the trial of injecting e4/4s with a virus that changes their brains to produce a mixture of e2 and e4 (the hope is for more than half e2) has started. This seems like a promising approach, although there's no guarantee it'll be effective and won't cause ...
by ApropoE4
Tue Oct 22, 2019 9:46 am
Forum: Science and Research
Topic: halting Phase III trials of aducanumab
Replies: 17
Views: 3778

Re: halting Phase III trials of aducanumab

It reduces the rate of decline by about 25% in the high dose group In EMERGE, which met its pre-specified primary endpoint in the new analysis, patients treated with high dose aducanumab showed a significant reduction of clinical decline from baseline in CDR-SB scores at 78 weeks (23% versus placebo...
by ApropoE4
Sat Oct 06, 2018 5:42 pm
Forum: Science and Research
Topic: Flu vaccines dangerous?
Replies: 14
Views: 4314

Re: Flu vaccines dangerous?

If you want to tackle this rationally, you might want to look into the amounts of metals you get from the flu vaccine and then if you still feel like you should avoid it then you should know you're not being rational.
by ApropoE4
Tue Aug 28, 2018 9:31 am
Forum: Announcements and Events
Topic: E-Scape Bio event, late June, San Francisco
Replies: 6
Views: 2580

Re: E-Scape Bio event, late June, San Francisco

From reading the tea leaves it seems like E-Scape are going to clinical trials with an S1P5 receptor agonist early next year, but that the APOE4 structure corrector isn't getting there before 2020 at the earliest. http://e-scapebio.com/news/releases/e-scape-bio-appoints-julie-anne-smith-president-an...
by ApropoE4
Sat Aug 25, 2018 9:20 am
Forum: Science and Research
Topic: Lectins and their benefits
Replies: 113
Views: 27126

Re: Lectins and their benefits

Certainly that is your choice. But are you aware Dr Bredesen advocates eliminating gluten. In his book, The End of Alzheimer's on page 46 of 308, kindle location 706 of 4911 he provides a list of foods containing high gluten to which he writes, "all of which are to be avoided as much as possib...
by ApropoE4
Thu Aug 23, 2018 12:11 pm
Forum: The Social Hour
Topic: Gundry Soda
Replies: 30
Views: 9030

Re: Gundry Soda

Other than being bad for your teeth it's very difficult to imagine it would have any effect or benefit. Imagine a bit harder! Or just do a PubMed search. The effects are small and not too impressive and probably all are a result of delayed gastric emptying. But still. Either way, the fluid I prefer...

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