Our 3rd annual meet-up will piggyback on the LowCarb USA conference in San Diego, CA, August 3-6.

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by ApropoE4
Tue May 16, 2017 8:46 pm
Forum: Prevention and Treatment
Topic: New Gundry Book - The Plant Paradox
Replies: 47
Views: 2447

Re: New Gundry Book - The Plant Paradox

You should especially watch out for animals that go quack. http://www.realclearscience.com/blog/2017/05/16/non-celiac_gluten_sensitivity_still_probably_doesnt_exist.html The Plant Paradox book lists 11 ill effects of consuming wheat germ agglutinin. If he's only right on half of them, it's still nas...
by ApropoE4
Wed Mar 22, 2017 12:10 am
Forum: Science and Research
Topic: A new role for ApoE explains its diverse range of effects, particularly in Alzheimer's
Replies: 18
Views: 1412

Re: A new role for ApoE explains its diverse range of effects, particularly in Alzheimer's

E-Scape Bio, the company working on the APOE4 structure corrector, has held 14 meetings at the Gladstone institute in May, some with Mahley, some with the computational drug discovery company (Numerate). This is up from 3-4 meetings a months previously. Either something is working very well, or ver...
by ApropoE4
Wed Jan 18, 2017 10:09 pm
Forum: Science and Research
Topic: Statins probably somewhat protective for women
Replies: 26
Views: 1274

Re: Statins probably somewhat protective for women

I had no response because there is no response that would satisfy an ideologue. In scientific research (especially such that takes place in industry), we often, very very often, are happy to use known associations even if we don't understand the underlying mechanisms of action - of course we are hap...
by ApropoE4
Wed Jan 18, 2017 5:58 pm
Forum: Science and Research
Topic: Statins probably somewhat protective for women
Replies: 26
Views: 1274

Re: Statins probably somewhat protective for women

I'm failing to understand experiment design or the difference between causality and correlation Exactly! :-) Seriously, selection bias is real. Maybe, for example, statin users are sicker than non-statin users and are therefore more prone to dying of other things. Note that this study cherry-picked...
by ApropoE4
Tue Jan 17, 2017 11:29 pm
Forum: Science and Research
Topic: Statins probably somewhat protective for women
Replies: 26
Views: 1274

Re: Statins probably somewhat protective for women

1. Do you agree that the observational study rules out the option that statins cause LOAD in the aging general population? 2. Do you agree with the headline of this topic and ate just nitpicking? 3. Do you agree that, regardless of the cause, the study identifies an effect, and that effect is a redu...
by ApropoE4
Tue Jan 17, 2017 9:34 pm
Forum: Science and Research
Topic: Statins probably somewhat protective for women
Replies: 26
Views: 1274

Re: Statins probably somewhat protective for women

In one corner, a study based on 400,000 medicare patients shows a small but statistically significant protective effect (note I am being reserved because it's an epidemiological study and it might be correlation rather than causation, and also because it's not 4/4 specific) So, in summary, the stud...
by ApropoE4
Mon Jan 16, 2017 1:23 pm
Forum: Science and Research
Topic: Statins probably somewhat protective for women
Replies: 26
Views: 1274

Re: Statins probably somewhat protective for women

Here is all you need to know about that paper - In one corner, a study based on 400,000 medicare patients shows a small but statistically significant protective effect (note I am being reserved because it's an epidemiological study and it might be correlation rather than causation, and also because ...
by ApropoE4
Mon Jan 16, 2017 12:20 am
Forum: Science and Research
Topic: Statins probably somewhat protective for women
Replies: 26
Views: 1274

Statins probably somewhat protective for women

Possibly for men as well. http://jamanetwork.com/journals/jamaneurology/fullarticle/2591317?resultClick=1 Results The 399 979 study participants included 7794 (1.95%) black men, 24 484 (6.12%) black women, 11 200 (2.80%) Hispanic men, 21 458 (5.36%) Hispanic women, 115 059 (28.77%) white men, and 19...
by ApropoE4
Thu Jan 12, 2017 3:26 am
Forum: Science and Research
Topic: Intervention study shows that food quality trumps macronutrient ratios
Replies: 7
Views: 373

Re: Intervention study shows that food quality trumps macronutrient ratios

I take no issue with the idea that caloric restriction is key, and the specific dietary composition only has a very small relative effect. I do take issue with researchers trying to promote an agenda around a result that simply shows restricting calories improves health, at least if you started off ...
by ApropoE4
Thu Jan 12, 2017 12:39 am
Forum: Science and Research
Topic: Intervention study shows that food quality trumps macronutrient ratios
Replies: 7
Views: 373

Re: Intervention study shows that food quality trumps macronutrient ratios

MarcR wrote:If there is a controlled intervention study that prescribes lowly processed foods in various proportions to millions of fully genotyped people and follows up with them for decades to ensure that they stick to the diets


Look outside your window :lol:

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