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by MarcR
Mon Jun 24, 2019 4:38 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 43
Views: 1196

Re: Zero carb diet will help prevent Alzheimer’s

I should link Julie's excellent prior topic:

Rethinking the etiology of CAD
by MarcR
Mon Jun 24, 2019 4:34 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 43
Views: 1196

Re: Zero carb diet will help prevent Alzheimer’s

Exactly (agreeing with jgilberAZ). On this point, Peter at Hyperlipid has a great new post today in which he uses images of real arteries to illustrate the impossibility of the lipid hypothesis. I recommend the whole thing and the comments. Here's an excerpt: It is very, very hard to explain how utt...
by MarcR
Mon Jun 24, 2019 4:02 pm
Forum: Prevention and Treatment
Topic: Keto, blood surgar, cholesterol, protein--how to balance?
Replies: 24
Views: 745

Re: Keto, blood surgar, cholesterol, protein--how to balance?

I recommend the article and the bidirectional references, not the simplistic calculator. The article seems clear and reasonable to me. This is not an exact science - I view this resource as a starting point for individuals to explore the protein quantity issue for themselves in the context of scient...
by MarcR
Mon Jun 24, 2019 3:27 pm
Forum: Prevention and Treatment
Topic: Keto, blood surgar, cholesterol, protein--how to balance?
Replies: 24
Views: 745

Re: Keto, blood surgar, cholesterol, protein--how to balance?

Examine.com targets a lay audience, so they frame their recommendations against the number everyone knows - body weight - the status everyone knows - healthy weight, overweight / obese, pregnant, lactating - and the objective everyone knows - maintenance, muscle gain, fat loss. No calculation is nee...
by MarcR
Thu Jun 20, 2019 10:00 am
Forum: Prevention and Treatment
Topic: Keto, blood surgar, cholesterol, protein--how to balance?
Replies: 24
Views: 745

Re: Keto, blood surgar, cholesterol, protein--how to balance?

Perhaps, but Dr. Bredesen would argue the majority of that evidence is based upon a very unhealthy Western population. I find this type of argument persuasive in the context of observational studies, which don't establish causation. Fortunately, on this topic of protein consumption we can do better...
by MarcR
Sat Jun 15, 2019 9:14 am
Forum: Prevention and Treatment
Topic: Keto, blood surgar, cholesterol, protein--how to balance?
Replies: 24
Views: 745

Re: Keto, blood surgar, cholesterol, protein--how to balance?

Only fair to share Examine.com's response:

Scientific Research and our Article in the Guardian

In my experience, the organization is true to its mission:

About Us
by MarcR
Fri Jun 14, 2019 10:57 pm
Forum: Prevention and Treatment
Topic: Keto, blood surgar, cholesterol, protein--how to balance?
Replies: 24
Views: 745

Re: Keto, blood surgar, cholesterol, protein--how to balance?

Thanks for reminding me of Lyon's work, circular. Her ideas offer a compelling theoretical framework for the overwhelming experimental evidence that we need far more than the US RDA for optimal health. Have those taking the opposite position - Rosedale, Gundry, presumably others - been able to go be...
by MarcR
Fri Jun 14, 2019 12:21 pm
Forum: Prevention and Treatment
Topic: Keto, blood surgar, cholesterol, protein--how to balance?
Replies: 24
Views: 745

Re: Keto, blood surgar, cholesterol, protein--how to balance?

Dr. Bredesen recommends between 0.8-1.0 grams (g) per kilogram (kg) of lean body mass (LBM) daily. Examine.com has continued to improve their How much protein do you need per day? article. Today's update relies on evidence from 109 papers including 17 from 2018 and 2019. The article text refers to ...
by MarcR
Sat May 25, 2019 4:07 pm
Forum: Science and Research
Topic: Plasmalogens- exciting new evidence
Replies: 92
Views: 11943

Re: Plasmalogens- exciting new evidence

The evidence that high plasmalogen levels (PBV) protect against dementia is compelling. Unfortunately, there are no commercially available PBV tests. What's the best practical way to estimate PBV? In Table 4, I see that the strongest relationship in the entire matrix connects plasmalogens (PBV) with...
by MarcR
Sat May 11, 2019 3:47 pm
Forum: Science and Research
Topic: ApoB, small-dense LDL-C, Lp(a), LpPLA2 activity, and cognitive change
Replies: 12
Views: 685

Re: ApoB, small-dense LDL-C, Lp(a), LpPLA2 activity, and cognitive change

This certainly pours cold water on the "higher the better" cholesterol/cognition theory Straw man? I recall more nuance than "higher the better". We have discussed the weakness of the lipid hypothesis at length and have identified high-powered studies which note that mortality r...

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