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by MarcR
Tue Dec 01, 2020 9:28 am
Forum: Prevention and Treatment
Topic: Low insulin pathway to dementia?
Replies: 17
Views: 1363

Re: Low insulin pathway to dementia?

When I ask him about factors mentioned by Bredesen in Type 3 diabetes Joe, I want to be sure that I communicated this point about Type 3 Alzheimer's effectively. Bredesen's schema includes four types of Alzheimer's: ⋅  Type 1 : Inflammatory. Chronic inflammation, often abetted by an overa...
by MarcR
Mon Nov 30, 2020 10:20 am
Forum: Prevention and Treatment
Topic: Low insulin pathway to dementia?
Replies: 17
Views: 1363

Re: Low insulin pathway to dementia?

Joe, I agree with Tincup that you don't seem insulin resistant. Do you continue to meet the criteria for a positive dementia diagnosis today? If so, I wonder if you have something else going on. Are you familiar with Dale Bredesen's Type 3 Alzheimer's classification?
by MarcR
Thu Nov 12, 2020 2:58 pm
Forum: ApoE4.Info, Inc.
Topic: Upcoming site access issue (Let's Encrypt)
Replies: 3
Views: 1556

Upcoming site access issue (Let's Encrypt)

The problem. If you use a device running an Android version prior to 7.1.1, beginning January 11 your access from that device to this site and many others will be impaired. (7.1.1 was released only four years ago, and a third of all Android devices are running older versions.) When you attempt to v...
by MarcR
Tue Oct 27, 2020 6:37 pm
Forum: Science and Research
Topic: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
Replies: 23
Views: 2662

Re: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

I agree that Fiver's summary is excellent and would also like to thank everyone participating in this fantastic topic.
by MarcR
Sun Sep 20, 2020 1:46 pm
Forum: Prevention and Treatment
Topic: Breakthrough on Deep Sleep Issue
Replies: 6
Views: 1376

Re: Breakthrough on Deep Sleep Issue

I learned that restless legs can impact deep sleep from my Oura 2 Ring as it measures "restlessness" and that measure has dropped along with improvements in deep sleep. It sounds as though the Oura 2 estimates deep sleep by tracking "restlessness" as a surrogate marker. One of t...
by MarcR
Sun Aug 16, 2020 9:59 pm
Forum: Prevention and Treatment
Topic: Discount for 100% pastured beef
Replies: 6
Views: 1147

Re: Discount for 100% pastured beef

I have been a satisfied monthly subscriber to the Prairie Ground Box since last November. Recommended!
by MarcR
Sun Jun 28, 2020 8:27 pm
Forum: Our Stories
Topic: 3/4 new here with high LDL after 3-months keto
Replies: 19
Views: 2647

Re: 3/4 new here with high LDL after 3-months keto

Great handle and first post, apoe4thebetter - welcome. You seem to have a solid strategy and are refining and optimizing rather than fixing big problems - congratulations on being so well-positioned for an extended health span. I imagine that you are familiar with Dave Feldman's work, but just in ca...
by MarcR
Wed Jun 17, 2020 11:33 am
Forum: Prevention and Treatment
Topic: Fiji water (silica rich water) - Reversal of Alzheimer's
Replies: 95
Views: 35948

Re: Fiji water (silica rich water) - Reversal of Alzheimer's

There is no data showing that MMST facilitates elimination of aluminum from the body. This 2018 paper addressed that question: Anti-Aging Effects of Monomethylsilanetriol and Maltodextrin-Stabilized Orthosilicic Acid on Nails, Skin and Hair Because it was cosmetics research, it analyzed aluminum co...
by MarcR
Tue Jun 16, 2020 3:22 pm
Forum: Prevention and Treatment
Topic: Fiji water (silica rich water) - Reversal of Alzheimer's
Replies: 95
Views: 35948

Re: Fiji water (silica rich water) - Reversal of Alzheimer's

Laurie, what does Dennis think of monomethylsilanetriol as a silica source? It's expensive relative to the home chemistry recipe, but it's way more convenient. Here's a source for the Orgono product, and here are some relevant references: The silicon supplement ‘Monomethylsilanetriol’ is safe and in...
by MarcR
Fri Jun 05, 2020 12:35 pm
Forum: Prevention and Treatment
Topic: How long for dietary change to show up in bloodwork
Replies: 5
Views: 1310

Re: How long for dietary change to show up in bloodwork

Dave Feldman has documented large day-by-day lipid differences related to dietary changes via extensive self-testing. He has developed a theory - the lipid energy model - to explain that variability along with other important discrepancies between the conventional wisdom and what the world's collect...

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