Welcome, Paige! Are you familiar with Dave Feldman's work? His site is Cholesterol Code , and a vibrant affiliated community of people striving to understand the implications of higher lipid levels in conjunction with overall strength and well being has formed on Facebook at Lean Mass Hyper-responde...

Parsing your words ... leaves out Statin users(which makes the study flawed) Exclude statin users = "study flawed" if you leave the statin users in you are again confounding Include statin users = "confounding" By this logic, all lipid studies conducted since the inception of sta...

Great point, NewRon. I split the topic at the point that the link to Attia's email, which was about CVD risk, not Alzheimer's, was introduced.

They left out Statin users thereby confounding the population pool they sampled from. This results in a sampling bias as the high cholesterol portion that has high cardiovascular risk would be left out. The entire study screened out people with existing diabetes and heart disease, so the statin use...

if saturated fats are bad for those with the APO4 gene Just a quick note to let you know that consensus on this point does not exist. Here's a topic linking and discussing a noted nutrition scientist's views: Chris Masterjohn on saturated fat Because some members notice that their LDL-C levels rise...

That looks like a terrific new paper, Susan - great find! I didn't have any luck acquiring the full paper as it does not yet seem to be on Sci-Hub . Fortunately the abstract does a great job of hitting the high points. So there might be a corollary that you don't want high LDL with the presence of i...

all things equal a lower LDL equates to a lower CHD-CVD risk. The evidence suggests otherwise. This 8-year study of 100,000+ people aged 50+ without preexisting diabetes or heart disease is the only high-powered study I have seen that focuses on the lipids of healthy older people. I am skeptical of...

Attia emphasizes the "mental gymnastics" required to understand Mendelian randomization (MR) and suggests that those of us who are intimidated by the work required ... I had to print it out, put a spreadsheet together, and build my own model to fully digest it. It took a lot longer than I ...

Washington Post article about a 94-year-old who fasted to hasten death. Her daughter made a short film of the experience: https://wapo.st/2PJl2nW

This topic attracted a couple of new members seeking to advertise the Xcode Life raw dna data analysis service. (The moderation team thwarted their efforts.) I believe Xcode Life is a scam site. It pains me to see it listed first in this topic name as it is not in the same league as the services off...