Missed that one. Thanks for the reference. Saturated fat does bad things to my lipids, so I'm definitely interested in reading that. Faghihina, Krauss (2012) Effects of Dietary saturated fat on LDL subclasses and apolipoprotein CIII in men Focus on table #5 In the setting of moderate carbohydrate i...

I read about this yesterday and found the HDL and apoC3 level connection interesting. Here's .... their earlier work on the apoE, HDL and apoC3 connection. That's a great paper. Thanks for posting that. I'm sure you already know about the Krauss paper (Faghihina, Krauss 2012) indicating a high SFA ...

FYI - Dr. Rowin is moving out of state and is not taking new patients at this time.

Pharmaceutical grade. If anyone wants:

https://mitolab.com/product/mb-pure-met ... 0ml-100ml/

FitFoodie wrote:I've googled this and seen three months, but I'm curious to hear your experiences about how long you have to eat differently for it to possibly show up in your bloodwork, particular lipid profile.

In most RCT studies, it's at least 1 month.

The PURE study is interesting. But I wouldn't make any dietary changes based on it, especially without a solid understanding of the metabolic mechanism of action that would explain why saturated fats are superior, particularly to MUFAs and PUFAs. Until then, it's just an interesting association from...

Good thoughts. Yea, I'm catching up on some of these seminars and now going back over some of my old notes -- with a particular focus on cholesterol metabolism. There certainly won't be a single bullet, given the complexity of the matter. I thought the Efavirenz Rik was talking about was interesting...

Thanks for your notes Fiver. I'm referring to them as I review these presentations at 1.75x speed. Do you (or anyone) have an understanding of why Julia TCW found a ~20% increase in free cholesterol (not cholesterol esters) associated with ApoE4 iPSC but Rik van der Kant indicated that the driver of...

It's great that you are taking notes, but can you have new paragraphs and break up this content? It's like 1 run-on statement.

Rauch, J., Luna, G., Guzman, E., Audouard, M., Challis, C., & Sibih, Y. et al. (2020). LRP1 is a master regulator of tau uptake and spread. Nature. doi:10.1038/s41586-020-2156-5 Abstract The spread of protein aggregates during disease progression is a common theme underlying many neurodegenerati...