IIRC, phosphatidylcholine is the best choline supplement wrt TMAO. I cannot find a reference on this matter, but I remember looking at this information and coming to that conclusion.

I'm partial to salsalate or acetyl-salicylic acid, found in aspirin. Fleischman, A., Shoelson, S., Bernier, R., & Goldfine, A. (2007). Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults. Diabetes Care, 31(2), 289-294. doi: 10.2337/dc07-1338 Min SW, Chen X, Tracy TE, et...

I was pleasantly surprised to find this Shulman interview in my podcast list for Attia. I've gone through it once, but need to do it at least 1 more time. I would add going for a walk after a meal (i.e. AMPK-mediated GLUT4 translocation) as a recommendation to insulin resistance. Additionally other ...

Missed that one. Thanks for the reference. Saturated fat does bad things to my lipids, so I'm definitely interested in reading that. Faghihina, Krauss (2012) Effects of Dietary saturated fat on LDL subclasses and apolipoprotein CIII in men Focus on table #5 In the setting of moderate carbohydrate i...

I read about this yesterday and found the HDL and apoC3 level connection interesting. Here's .... their earlier work on the apoE, HDL and apoC3 connection. That's a great paper. Thanks for posting that. I'm sure you already know about the Krauss paper (Faghihina, Krauss 2012) indicating a high SFA ...

FYI - Dr. Rowin is moving out of state and is not taking new patients at this time.

Pharmaceutical grade. If anyone wants:

https://mitolab.com/product/mb-pure-met ... 0ml-100ml/

FitFoodie wrote:I've googled this and seen three months, but I'm curious to hear your experiences about how long you have to eat differently for it to possibly show up in your bloodwork, particular lipid profile.

In most RCT studies, it's at least 1 month.

The PURE study is interesting. But I wouldn't make any dietary changes based on it, especially without a solid understanding of the metabolic mechanism of action that would explain why saturated fats are superior, particularly to MUFAs and PUFAs. Until then, it's just an interesting association from...

Good thoughts. Yea, I'm catching up on some of these seminars and now going back over some of my old notes -- with a particular focus on cholesterol metabolism. There certainly won't be a single bullet, given the complexity of the matter. I thought the Efavirenz Rik was talking about was interesting...