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by aphorist
Wed Jan 06, 2021 8:34 am
Forum: Prevention and Treatment
Topic: Gundry Diet and Choline
Replies: 13
Views: 1622

Re: Gundry Diet and Choline

IIRC, phosphatidylcholine is the best choline supplement wrt TMAO. I cannot find a reference on this matter, but I remember looking at this information and coming to that conclusion.
by aphorist
Mon Dec 28, 2020 10:15 am
Forum: Science and Research
Topic: Compounds that seem to improve brain hypometabolism
Replies: 3
Views: 1850

Re: Compounds that seem to improve brain hypometabolism

I'm partial to salsalate or acetyl-salicylic acid, found in aspirin. Fleischman, A., Shoelson, S., Bernier, R., & Goldfine, A. (2007). Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults. Diabetes Care, 31(2), 289-294. doi: 10.2337/dc07-1338 Min SW, Chen X, Tracy TE, et...
by aphorist
Fri Dec 25, 2020 8:57 am
Forum: Science and Research
Topic: Master class on insulin resistance
Replies: 1
Views: 667

Re: Master class on insulin resistance

I was pleasantly surprised to find this Shulman interview in my podcast list for Attia. I've gone through it once, but need to do it at least 1 more time. I would add going for a walk after a meal (i.e. AMPK-mediated GLUT4 translocation) as a recommendation to insulin resistance. Additionally other ...
by aphorist
Fri Jul 17, 2020 9:19 am
Forum: Science and Research
Topic: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep
Replies: 5
Views: 1423

Re: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep

Missed that one. Thanks for the reference. Saturated fat does bad things to my lipids, so I'm definitely interested in reading that. Faghihina, Krauss (2012) Effects of Dietary saturated fat on LDL subclasses and apolipoprotein CIII in men Focus on table #5 In the setting of moderate carbohydrate i...
by aphorist
Fri Jul 17, 2020 5:52 am
Forum: Science and Research
Topic: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep
Replies: 5
Views: 1423

Re: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep

I read about this yesterday and found the HDL and apoC3 level connection interesting. Here's .... their earlier work on the apoE, HDL and apoC3 connection. That's a great paper. Thanks for posting that. I'm sure you already know about the Krauss paper (Faghihina, Krauss 2012) indicating a high SFA ...
by aphorist
Mon Jun 15, 2020 12:27 pm
Forum: Practitioner Reviews
Topic: Julie Rowin, MD / Westchester, IL
Replies: 12
Views: 6837

Re: Julie Rowin, MD / Westchester, IL

FYI - Dr. Rowin is moving out of state and is not taking new patients at this time.
by aphorist
Fri Jun 05, 2020 9:45 am
Forum: Prevention and Treatment
Topic: How long for dietary change to show up in bloodwork
Replies: 5
Views: 1549

Re: How long for dietary change to show up in bloodwork

FitFoodie wrote:I've googled this and seen three months, but I'm curious to hear your experiences about how long you have to eat differently for it to possibly show up in your bloodwork, particular lipid profile.


In most RCT studies, it's at least 1 month.
by aphorist
Mon Jun 01, 2020 12:24 pm
Forum: Science and Research
Topic: Large new study: whole fat dairy linked to lower metabolic disease risk
Replies: 13
Views: 2463

Re: Large new study: whole fat dairy linked to lower metabolic disease risk

The PURE study is interesting. But I wouldn't make any dietary changes based on it, especially without a solid understanding of the metabolic mechanism of action that would explain why saturated fats are superior, particularly to MUFAs and PUFAs. Until then, it's just an interesting association from...
by aphorist
Wed May 27, 2020 11:55 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 4492

Re: Alzheimer's Afternoons Seminar Series Summaries

Good thoughts. Yea, I'm catching up on some of these seminars and now going back over some of my old notes -- with a particular focus on cholesterol metabolism. There certainly won't be a single bullet, given the complexity of the matter. I thought the Efavirenz Rik was talking about was interesting...

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