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by aphorist
Fri Jul 17, 2020 9:19 am
Forum: Science and Research
Topic: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep
Replies: 5
Views: 837

Re: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep

Missed that one. Thanks for the reference. Saturated fat does bad things to my lipids, so I'm definitely interested in reading that. Faghihina, Krauss (2012) Effects of Dietary saturated fat on LDL subclasses and apolipoprotein CIII in men Focus on table #5 In the setting of moderate carbohydrate i...
by aphorist
Fri Jul 17, 2020 5:52 am
Forum: Science and Research
Topic: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep
Replies: 5
Views: 837

Re: Plasma ApoE Levels and Risk of Dementia—You Are the Company You Keep

I read about this yesterday and found the HDL and apoC3 level connection interesting. Here's .... their earlier work on the apoE, HDL and apoC3 connection. That's a great paper. Thanks for posting that. I'm sure you already know about the Krauss paper (Faghihina, Krauss 2012) indicating a high SFA ...
by aphorist
Mon Jun 15, 2020 12:27 pm
Forum: Practitioner Reviews
Topic: Julie Rowin, MD / Westchester, IL
Replies: 12
Views: 5573

Re: Julie Rowin, MD / Westchester, IL

FYI - Dr. Rowin is moving out of state and is not taking new patients at this time.
by aphorist
Fri Jun 05, 2020 9:45 am
Forum: Prevention and Treatment
Topic: How long for dietary change to show up in bloodwork
Replies: 5
Views: 867

Re: How long for dietary change to show up in bloodwork

FitFoodie wrote:I've googled this and seen three months, but I'm curious to hear your experiences about how long you have to eat differently for it to possibly show up in your bloodwork, particular lipid profile.


In most RCT studies, it's at least 1 month.
by aphorist
Mon Jun 01, 2020 12:24 pm
Forum: Science and Research
Topic: Large new study: whole fat dairy linked to lower metabolic disease risk
Replies: 13
Views: 1400

Re: Large new study: whole fat dairy linked to lower metabolic disease risk

The PURE study is interesting. But I wouldn't make any dietary changes based on it, especially without a solid understanding of the metabolic mechanism of action that would explain why saturated fats are superior, particularly to MUFAs and PUFAs. Until then, it's just an interesting association from...
by aphorist
Wed May 27, 2020 11:55 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2842

Re: Alzheimer's Afternoons Seminar Series Summaries

Good thoughts. Yea, I'm catching up on some of these seminars and now going back over some of my old notes -- with a particular focus on cholesterol metabolism. There certainly won't be a single bullet, given the complexity of the matter. I thought the Efavirenz Rik was talking about was interesting...
by aphorist
Mon May 25, 2020 9:33 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2842

Re: Alzheimer's Afternoons Seminar Series Summaries

Thanks for your notes Fiver. I'm referring to them as I review these presentations at 1.75x speed. Do you (or anyone) have an understanding of why Julia TCW found a ~20% increase in free cholesterol (not cholesterol esters) associated with ApoE4 iPSC but Rik van der Kant indicated that the driver of...
by aphorist
Wed Apr 08, 2020 12:00 pm
Forum: Science and Research
Topic: Online Alzheimer's Afternoons Seminar Series
Replies: 13
Views: 2056

Re: Online Alzheimer's Afternoons Seminar Series

It's great that you are taking notes, but can you have new paragraphs and break up this content? It's like 1 run-on statement.
by aphorist
Thu Apr 02, 2020 12:32 pm
Forum: Science and Research
Topic: LRP1 is a master regulator of tau uptake and spread
Replies: 1
Views: 926

LRP1 is a master regulator of tau uptake and spread

Rauch, J., Luna, G., Guzman, E., Audouard, M., Challis, C., & Sibih, Y. et al. (2020). LRP1 is a master regulator of tau uptake and spread. Nature. doi:10.1038/s41586-020-2156-5 Abstract The spread of protein aggregates during disease progression is a common theme underlying many neurodegenerati...

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