Search found 237 matches
- Mon Apr 15, 2024 3:52 am
- Forum: Science and Research
- Topic: While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
- Replies: 0
- Views: 64
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
https://www.alzforum.org/news/research-news/while-fly-sleeps-its-glia-burn-neuronal-lipids-refresh-brain This is a really great overview of a mechanistic paper showing how neurons generate oxidized lipids, the lipids are shuttled to astrocytes (glia cells) that take up, the glia form lipid droplets,...
- Sun Apr 14, 2024 4:20 am
- Forum: Science and Research
- Topic: Hopeful Peter Attia Podcast with John Kastelein
- Replies: 5
- Views: 8252
Re: Hopeful Peter Attia Podcast with John Kastelein
Beginning at 1:41:30 https://youtu.be/Jduj5SL5FNs?si=mB5cTOUKGc9T-jk7&t=6090
John Kastelein, MD PhD
Worth listening to for anyone interested in the functionality (or lack thereof) of ApoE4. Notes attached.
John Kastelein, MD PhD
Worth listening to for anyone interested in the functionality (or lack thereof) of ApoE4. Notes attached.
- Sun Apr 14, 2024 2:09 am
- Forum: Prevention and Treatment
- Topic: has anyone tried semax?
- Replies: 4
- Views: 23643
Re: has anyone tried semax?
I've used Semax. It was recommended to me by a doctor. But I also have a complicating factor like a head injury/TBI. It worked for me, but I'm wary of taking any hormones, pro-hormone (excluding vitamin d), or peptides for any lengthy period of time. And when I say it worked, I only mean it was bene...
- Sun Apr 14, 2024 2:04 am
- Forum: Science and Research
- Topic: Why do different types of saturated fat affect the ApoE4 brain differently?
- Replies: 4
- Views: 7309
Re: Why do different types of saturated fat affect the ApoE4 brain differently?
Not all SFA are the same. Short chain fatty acids are typically beneficial/neutral. Long chain SFA like palmitic acid would be associated with inflammation.
- Sat Mar 16, 2024 7:32 am
- Forum: Science and Research
- Topic: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
- Replies: 17
- Views: 19554
Re: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
Thanks so much for these notes and papers, JNB. They are truly great thoughts and points.
- Sun Mar 10, 2024 9:20 am
- Forum: Science and Research
- Topic: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
- Replies: 17
- Views: 19554
Re: Neurodegeneration—It’s Not the Tangles, It’s the T Cells
interesting paper and work. sort of creates more questions than answers, but every little step forward is useful.
- Sun Mar 10, 2024 8:33 am
- Forum: Science and Research
- Topic: Homotaurine (tramiprosate) appears to be a structure corrector
- Replies: 77
- Views: 190426
Re: Homotaurine (tramiprosate) appears to be a structure corrector
Aphorist. Good question. The Alzheon studies didn't look at different time of day dosing. I'm not sure it would make a huge difference, but, like you, I haven't yet fully digested the Nemergut paper. I'm aiming for the apoE4 structure corrector function, which makes me want to take homotaurine thro...
- Sun Mar 10, 2024 8:27 am
- Forum: Prevention and Treatment
- Topic: Periodontitis / Gingivitis / Gum Disease in E4/E4
- Replies: 32
- Views: 58446
Re: Periodontitis / Gingivitis / Gum Disease in E4/E4
Does anyone know how to be tested for P. Gingivalis? Additionally, I found these interesting papers re: P Gingivalis Kobayashi, R., Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease. Sci Rep 7, 545 (2017). https:/...
- Sat Feb 24, 2024 7:56 pm
- Forum: Science and Research
- Topic: Homotaurine (tramiprosate) appears to be a structure corrector
- Replies: 77
- Views: 190426
Re: Homotaurine (tramiprosate) appears to be a structure corrector
I'm just catching up on this thread and material. It reminds me somewhat of EPPS: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques https://www.nature.com/articles/ncomms9997 https://forums.apoe4.info/viewtopic.php?t=1957 I hav...
- Sat Feb 24, 2024 4:56 pm
- Forum: Prevention and Treatment
- Topic: Modifiable risks and APOE 4/4
- Replies: 7
- Views: 11686
Re: Modifiable risks and APOE 4/4
I'd be careful of Attia's general guidance for health and then applying it to a E4/4. He seems to advocate a higher protein intake, that could be problematic for some people without some kind of fasting regimen or intermittent restriction.