https://www.alzforum.org/news/research-news/while-fly-sleeps-its-glia-burn-neuronal-lipids-refresh-brain This is a really great overview of a mechanistic paper showing how neurons generate oxidized lipids, the lipids are shuttled to astrocytes (glia cells) that take up, the glia form lipid droplets,...

Beginning at 1:41:30 https://youtu.be/Jduj5SL5FNs?si=mB5cTOUKGc9T-jk7&t=6090

John Kastelein, MD PhD

Worth listening to for anyone interested in the functionality (or lack thereof) of ApoE4. Notes attached.

I've used Semax. It was recommended to me by a doctor. But I also have a complicating factor like a head injury/TBI. It worked for me, but I'm wary of taking any hormones, pro-hormone (excluding vitamin d), or peptides for any lengthy period of time. And when I say it worked, I only mean it was bene...

Not all SFA are the same. Short chain fatty acids are typically beneficial/neutral. Long chain SFA like palmitic acid would be associated with inflammation.

Thanks so much for these notes and papers, JNB. They are truly great thoughts and points.

interesting paper and work. sort of creates more questions than answers, but every little step forward is useful.

Aphorist. Good question. The Alzheon studies didn't look at different time of day dosing. I'm not sure it would make a huge difference, but, like you, I haven't yet fully digested the Nemergut paper. I'm aiming for the apoE4 structure corrector function, which makes me want to take homotaurine thro...

Does anyone know how to be tested for P. Gingivalis? Additionally, I found these interesting papers re: P Gingivalis Kobayashi, R., Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease. Sci Rep 7, 545 (2017). https:/...

I'm just catching up on this thread and material. It reminds me somewhat of EPPS: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques https://www.nature.com/articles/ncomms9997 https://forums.apoe4.info/viewtopic.php?t=1957 I hav...

I'd be careful of Attia's general guidance for health and then applying it to a E4/4. He seems to advocate a higher protein intake, that could be problematic for some people without some kind of fasting regimen or intermittent restriction.