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by MAC
Fri Feb 03, 2017 9:41 pm
Forum: Science and Research
Topic: MUST READ for 3/4 carriers!
Replies: 25
Views: 5852

Re: MUST READ for 3/4 carriers!

Julie, I beg to differ re e2/e4 vs. e3/e4 risk. The ADDF table you attached, what is the study reference? The vast majority of studies I've seen, the risk of AD is much higher e3/e4 vs. e2/e4. I list below 3 references/graphs, and several other references (I had many many more but did not post table...
by MAC
Fri Feb 03, 2017 10:18 am
Forum: Prevention and Treatment
Topic: Book: The Mindspan Diet
Replies: 8
Views: 2259

Re: Book: The Mindspan Diet

I haven't read the book, and not sure what scientific studies the author references for his iron & AD thesis (quick glance seems to be a lot of "associations", e.g. fortified iron foods), but check out the Ferritin thread in the forum. There's been NO direct causative proof of serum ir...
by MAC
Fri Feb 03, 2017 8:35 am
Forum: Prevention and Treatment
Topic: Intermittent Fasting ... my input
Replies: 5
Views: 1682

Re: Intermittent Fasting ... my input

Just wanted to share how I've managed to do IF given that I never thought I could. For me it is not hell and I find it somewhat mentally satisfying. BTW... I have been able to keep my winter weight 15-20 lbs less than normal and am about 5 lbs up from my biking low for last year. It has been a LONG...
by MAC
Fri Feb 03, 2017 7:52 am
Forum: Science and Research
Topic: MUST READ for 3/4 carriers!
Replies: 25
Views: 5852

Re: MUST READ for 3/4 carriers!

Fascinating, I did not know that we had differing ratios of E4/E3 in our plasma! Apoe4 comprises at most about 25% of total plasma Apoe (both AD and normal cognitive controls). If you look at the graphical results, there are 2 persons that have apoe3 levels at about 120, whereas the average is about...
by MAC
Wed Feb 01, 2017 8:43 am
Forum: Science and Research
Topic: Cerebral glucose deprivation linked to cognitive deficits, tau neuropathy & synaptic dysfunction
Replies: 1
Views: 937

Re: Cerebral glucose deprivation linked to cognitive deficits, tau neuropathy & synaptic dysfunction

Is this your way of engaging us in "mental activities" Julie...these papers are very technical, difficult reads for us laypeople. :) Very interesting and exciting root cause work..taking h-tau mice (designed to express only human tau) and injecting them with 2-deoxyglucose (DG), inducing t...
by MAC
Tue Jan 31, 2017 2:49 pm
Forum: Prevention and Treatment
Topic: Chronic Inflammation as a contributor to Alzheimer’s
Replies: 310
Views: 71589

Re: Chronic Inflammation as a contributor to Alzheimer’s

Mother nature spent hundreds of millions of years developing all these nutrient, polyphenol, antioxidant rich vegetable plants ("weeds") and herbs, and ancestrally, we've been consuming them for the last couple of millions of years, so you'd "think" it would be common nutritional...
by MAC
Tue Jan 31, 2017 12:39 pm
Forum: Prevention and Treatment
Topic: Chronic Inflammation as a contributor to Alzheimer’s
Replies: 310
Views: 71589

Re: Chronic Inflammation as a contributor to Alzheimer’s

Endive, basil, chicory, radicchio, romaine, fennel bulb, dandelion...all readily consumed in a traditional mediterranean diet (6 of these are in my fridge). If I'm making a salad, it won't be without endive or radicchio or fennel. Chicory and Dandelion, talk about two ancestral "weeds". ht...
by MAC
Tue Jan 31, 2017 8:20 am
Forum: Prevention and Treatment
Topic: Research on the Hazda and exercise
Replies: 44
Views: 11275

Re: Research on the Hazda and exercise

Exercise, APOE genotype, and the evolution of the human lifespan (2014) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066890/pdf/nihms576184.pdf [MAC] Essentially, our increased longevity evolved ancestrally when we developed aerobic/endurance capabilities, and the current mismatch between heritage ...
by MAC
Sun Jan 29, 2017 1:12 pm
Forum: Prevention and Treatment
Topic: NMR LipoProfile Test Result Questions
Replies: 24
Views: 6154

Re: NMR LipoProfile Test Result Questions

Yes it is a tradeoff, I am trying to stay more on the longevity side of the line at this point in my life. Trying to keep my IGF-1 and mTOR low while still staying healthy and keep some muscle. I am also curious what Dr. Gundry's thoughts are on developing / maintaining muscle without mTOR and keep...
by MAC
Sun Jan 29, 2017 11:36 am
Forum: Prevention and Treatment
Topic: NMR LipoProfile Test Result Questions
Replies: 24
Views: 6154

Re: NMR LipoProfile Test Result Questions

Noted, at later stages in life, the cholesterol inverse applies: higher cholesterol = reduced mortality. Yes, it's pretty much a correlation with reduced health later in life...loss in BMI and strength, neurodegenerative, metabolic syndrome. But in midlife , from what I've read, having high choleste...

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