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by J11
Tue Jun 30, 2020 6:21 pm
Forum: Science and Research
Topic: LATE To The Game
Replies: 3
Views: 886

Re: LATE To The Game

The emergence of LATE to refine the differential diagnosis of Alzheimer's had until late entirely escaped my attention. However, it is of considerable importance that Alzheimer's be a clearly defined neuropathology, otherwise clinical trials might wrongly conclude that treatments were ineffective. F...
by J11
Mon Jun 29, 2020 1:29 pm
Forum: Science and Research
Topic: study: Tb vaccine lowers AD risk.
Replies: 15
Views: 1525

Re: study: Tb vaccine lowers AD risk.

Right about now I am feeling super clever. I suppose once one has been around here for a while certain learning should be expected. I will not give away le étonnement completely, though the article below is the first hint and the second hint is: Give me an M, now Give me a P, etc. https://www.ncbi.n...
by J11
Mon Jun 29, 2020 1:06 pm
Forum: Science and Research
Topic: Genetic Classifications of Alzheimer's subtypes
Replies: 1
Views: 194

Re: Genetic Classifications of Alzheimer's subtypes

The SNP genotyper R package will provide substantial rewards with little effort. As an illustration, below is a list of all SNPs listed on NCBI clinvar's for variants considered pathogenic for Alzheimer's Disease. https://www.ncbi.nlm.nih.gov/clinvar An R package could provide us with an immediate a...
by J11
Mon Jun 29, 2020 8:57 am
Forum: Science and Research
Topic: Genetic Classifications of Alzheimer's subtypes
Replies: 1
Views: 194

Genetic Classifications of Alzheimer's subtypes

An even more powerful method has emerged to unravel the different features of Alzheimer's. The below article subdivides Alzheimer's into the domains of memory, language, executive function and visuospatial. The creation of these so called coherent subgroups should allow for identifying SNPs with sma...
by J11
Sun Jun 21, 2020 1:23 pm
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 9
Views: 803

Re: How do specificity and sensitivity work with lab testing?

TheBrain, 99% is a near ideal circumstance. In many tests the available information is much less precise. Consider the Receiver Operating Curve (ROC) for APOE genotype in distinguishing AD from a healthy control. Area under the Curve (AUC) is 0.90. Here you might have a false positive rate of 25% wi...
by J11
Thu Jun 11, 2020 7:33 pm
Forum: Prevention and Treatment
Topic: Methylene Blue AD Cure Celebration Thread!
Replies: 29
Views: 5574

Re: Methylene Blue AD Cure Celebration Thread!

Tincup, thank you reactivating this thread. For reference here is another MB thread that went through some number crunching with the clinical trials. https://www.apoe4.info/forums/viewtopic.php?f=4&t=6865&p=73361&hilit=methylen+blue#p73361 Hmm, there is also https://www.apoe4.info/forums...
by J11
Tue Jun 02, 2020 5:23 pm
Forum: Science and Research
Topic: Missing allele found in me
Replies: 13
Views: 718

Re: Missing allele found in me

Rare_case, your infectious enthusiasm will get others to genome sequence as well. This is what we need for the genomics age to begin. With such widespread genetic knowledge profound genetic change will occur in the community. One other approach that you might consider to phase your APOE result is to...
by J11
Mon Jun 01, 2020 4:51 pm
Forum: Science and Research
Topic: Missing allele found in me
Replies: 13
Views: 718

Re: Missing allele found in me

Tincup, thank you for pinging me! Rare_case, your friend genotyped rs7412 (CC), rs429358 (CT), which is the reasonably common APOE epsilon 34. There is no confusion with this genotype: one of the Cs (either one) from rs7412 must match up with the C from rs429358 and the remaining C from rs7412 must ...
by J11
Mon May 11, 2020 5:58 pm
Forum: Prevention and Treatment
Topic: Genetic genealogy raw data and Alzheimer's research ...
Replies: 134
Views: 29525

Re: Genetic genealogy raw data and Alzheimer's research ...

circ, thank you for replying! Very very exciting. It continues to look quite promising. I have had two early responses and neither suggest that this is a wrong turn. This has been a great adventure and I think I might finally have made some progress. I am glad that I have kept something of a log of ...
by J11
Sat May 09, 2020 9:45 pm
Forum: Prevention and Treatment
Topic: Genetic genealogy raw data and Alzheimer's research ...
Replies: 134
Views: 29525

Re: Genetic genealogy raw data and Alzheimer's research ...

Wow!! This is exciting! I had not been on our 23andme account for quite some time. I had not realized how many more people have caught onto the wave of genotyping. Basically, at this point you must be living in a cave or something not to get that we are all moving into a big global database in which...

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