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by J11
Fri Feb 02, 2018 10:39 am
Forum: Science and Research
Topic: Increased Serum Calcium Levels reduce AD? I could do that!
Replies: 5
Views: 199

Re: Increased Serum Calcium Levels reduce AD? I could do that!

I looked up the 8 SNPs above on a 23andme v3 chip.

rs7481584 was not on the chip though rs3814964 was and is a perfect proxy.
rs17711722 was also not on the chip and there was no proxy for it.
by J11
Fri Feb 02, 2018 10:09 am
Forum: Science and Research
Topic: Increased Serum Calcium Levels reduce AD? I could do that!
Replies: 5
Views: 199

Re: Increased Serum Calcium Levels reduce AD? I could do that!

Stavia, thank you your medical insight. I am not sure though why the authors talk of pursuing this with further research using supplements even when they note the homeostasis aspect of calcium regulation. Those on the forum might be interested in looking up the below calcium SNPs to help determine t...
by J11
Wed Jan 31, 2018 7:54 pm
Forum: Science and Research
Topic: Increased Serum Calcium Levels reduce AD? I could do that!
Replies: 5
Views: 199

Re: Increased Serum Calcium Levels reduce AD? I could do that!

JulieG, genetics might finally let us answer some of these tricky questions. We have never been sure what caused what, is something correlated or causal? It all gets hopelessly confusing. Yet, with Mendelian Randomization you have a fairly solid technique that can start to unravel things. If all we ...
by J11
Wed Jan 31, 2018 7:42 pm
Forum: Prevention and Treatment
Topic: Article: There's a Scary Link Between Bad Sleep And The Onset of Alzheimer's
Replies: 3
Views: 218

Re: Article: There's a Scary Link Between Bad Sleep And The Onset of Alzheimer's

circ, I don't want to brag... well actually I do. Here's a massive massive GWAS that found that insomnia does not appear to be positively related to AD. This seems surprising because I would have thought that beta amyloid would tend to build up in those with insomnia. https://www.biorxiv.org/content...
by J11
Wed Jan 31, 2018 7:37 pm
Forum: Science and Research
Topic: Increased Serum Calcium Levels reduce AD? I could do that!
Replies: 5
Views: 199

Increased Serum Calcium Levels reduce AD? I could do that!

"IVW analysis showed that a genetically increased serum calcium level (per 1 standard deviation (SD) increase 0.5-mg/dL) was significantly associated with a reduced AD risk (OR=0.56, 95% CI: 0.34-0.94, P=5.00E-03). " Seems like a fairly large effect. https://www.biorxiv.org/content/early/2...
by J11
Fri Jan 26, 2018 10:12 am
Forum: Science and Research
Topic: UKBB Alzheimer Study
Replies: 0
Views: 83

UKBB Alzheimer Study

Just by asking the 500,000 people in the UK Biobank study: "Did your mother/father exhibit Alzheimer's?" they were able to find some more AD genes. I was worried that the genetic answers for AD might never emerge, though with all the precision medicine efforts now underway such approaches ...
by J11
Tue Jan 23, 2018 6:50 pm
Forum: Prevention and Treatment
Topic: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community
Replies: 83
Views: 2881

Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

laurie, thank you for staying with the aluminum story and for the video suggestion. It would help our cause so much if there were some way to create a financial model for the needed silica research to be done. I find {and others might notice this as well} that it usually takes a few hints to make a ...
by J11
Sat Jan 20, 2018 1:20 pm
Forum: Science and Research
Topic: Genesis of the 1500 IQ Humanoids
Replies: 75
Views: 4051

Re: Genesis of the 1500 IQ Humanoids

We have let this thread drift for the last two months. Two months is an eternity when dealing with a fast developing technology. As soon as we hit the exponential elbow of the curve, we will need to sprint even to keep even. Due to the nature of the scientific publishing model, this is where the sta...
by J11
Thu Jan 11, 2018 11:22 am
Forum: Science and Research
Topic: New GWAS design identifies 6 new AD genes!
Replies: 2
Views: 152

Re: New GWAS design identifies 6 new AD genes!

Tom, this is GREAT! They spent a huge amount of money with IGAP and people can get tired with all these expenses and not a great deal of results. With this new research approach they used 100 times fewer people and obtained a third as many genes. Not bad! I would say that this represents a compellin...
by J11
Thu Jan 11, 2018 10:03 am
Forum: Science and Research
Topic: New GWAS design identifies 6 new AD genes!
Replies: 2
Views: 152

New GWAS design identifies 6 new AD genes!

With only 1200 affecteds they found 6 new genes and confirmed another?
They needed nearly 100,000 in IGAP to find 22!

https://www.biorxiv.org/content/early/2018/01/09/242545

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