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by J11
Sun Dec 10, 2017 4:45 pm
Forum: Science and Research
Topic: RAB10 - Gene Discovered to Protect Against Alzheimer's in High Risk Population
Replies: 14
Views: 450

Re: RAB10 - Gene Discovered to Protect Against Alzheimer's in High Risk Population

Orangeblossum, the Promethease report will include the SNP if the variant is found in your gene chip file. However, the 7485 SNP is not on the 23andme v3 or possibly other versions, so the report will likely not be able to make this determination. I find it quite frustrating that this was first repo...
by J11
Sun Dec 10, 2017 11:31 am
Forum: Prevention and Treatment
Topic: Genetic genealogy raw data and Alzheimer's research ...
Replies: 126
Views: 12345

Re: Genetic genealogy raw data and Alzheimer's research ...

Even more excitement! Genetic genealogy is going mainstream! It is almost impossible to imagine; 1.7 million Americans genotyped with Ancestry.com on the Thanksgiving Weekend? Ancestry.com is now on track to surpass 10 million in its DNA database within the next year. 23andme is now at 3 million and...
by J11
Sun Dec 10, 2017 9:32 am
Forum: Prevention and Treatment
Topic: Found out I carry the PSEN1 gene is this a death sentence?
Replies: 10
Views: 342

Re: Found out I carry the PSEN1 gene is this a death sentence?

giftsplash, best wishes as you cope with this new information. As a suggestion, you might consider using online genealogy/genetics databases to gain a better perspective of how this the PSEN1 variant fits into your family tree. In today's world of small families and often little or no contact with o...
by J11
Sat Dec 09, 2017 1:04 pm
Forum: Prevention and Treatment
Topic: Methylene Blue AD Cure Celebration Thread!
Replies: 13
Views: 407

Re: Methylene Blue AD Cure Celebration Thread!

Orangeblossum, I have stayed away from answering the question about the mechanism of action because with human biology as it is and the methods available to investigate it as they are, it might not be possible to unambiguously establish such an MOA. Human biology is so highly interconnected that cha...
by J11
Fri Dec 08, 2017 11:44 pm
Forum: Prevention and Treatment
Topic: Methylene Blue Phase 3 failed?
Replies: 15
Views: 1448

Re: Methylene Blue Phase 3 failed?

Remember to post to this thread with all the confusing details of the MB/LMTX trials!
The Celebration thread can be there when we work through everything and we want a party!

Get going on the reading assignment!
by J11
Fri Dec 08, 2017 11:41 pm
Forum: Prevention and Treatment
Topic: Methylene Blue AD Cure Celebration Thread!
Replies: 13
Views: 407

Re: Methylene Blue AD Cure Celebration Thread!

Homesteadgal, yes I had these same concerns at the time of ICAD in July of 2016. However, after reading the article for the second phase 3 with LMTX, the first phase 3 with LMTX, the phase 2 trial with MB, I am becoming more confident that this is for real. The phase 2 trial with Methylene Blue whic...
by J11
Fri Dec 08, 2017 9:01 pm
Forum: Prevention and Treatment
Topic: Genetic genealogy raw data and Alzheimer's research ...
Replies: 126
Views: 12345

Re: Genetic genealogy raw data and Alzheimer's research ...

Very exciting! The Alzheimer's Sequencing Project has finished sequencing of full genomes and exomes of a large number of multiplex Alzheimer families many without an APOE 4 allele. I have been worried for some time that victory has been declared in AD genetics even though the job is still not yet d...
by J11
Fri Dec 08, 2017 3:22 pm
Forum: Prevention and Treatment
Topic: Methylene Blue Phase 3 failed?
Replies: 15
Views: 1448

Re: Methylene Blue Phase 3 failed?

The complex, confusing and convoluted discussion of the various MB/LMTX trials can take place on this thread. It will be essential for those commenting to have done all the required readings as there will be a quiz on their contents. The first assigned reading is the phase 2 trial article for Methyl...
by J11
Fri Dec 08, 2017 3:04 pm
Forum: Prevention and Treatment
Topic: Methylene Blue AD Cure Celebration Thread!
Replies: 13
Views: 407

Re: Methylene Blue AD Cure Celebration Thread!

Orangeblossum, the methylene blue/LMTX trial results are difficult to interpret when only looking at the headlines. There are a few confusing aspects of these trials that have obscured the efficacy signals that were being sent. The biggest problem was that no phase 1 trials were ever published for m...
by J11
Sun Dec 03, 2017 5:16 pm
Forum: Prevention and Treatment
Topic: Methylene Blue AD Cure Celebration Thread!
Replies: 13
Views: 407

Re: Methylene Blue AD Cure Celebration Thread!

I am confused about Supplementary Table 1 versus Supplementary Table 2. In Supplementary Table 1 those on add-on with 4 mg had a decline of 3.97 points on MMSE versus 3.71 for those on monotherapy 4 mg. A nearly 8 point difference in MMSE is nearly impossible to believe. Yet, in Supplementary Table ...

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