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by J11
Fri Dec 15, 2017 5:46 pm
Forum: Prevention and Treatment
Topic: Methylene Blue Phase 3 failed?
Replies: 17
Views: 1517

Re: Methylene Blue Phase 3 failed?

For starters we can slowly and carefully work through the phase 2 article. https://content.iospress.com/download/journal-of-alzheimers-disease/jad142874?id=journal-of-alzheimers-disease%2Fjad142874 Line number 1: "Background: As tau aggregation pathology correlates with clinical dementia in Alz...
by J11
Fri Dec 15, 2017 5:20 pm
Forum: Prevention and Treatment
Topic: Methylene Blue Phase 3 failed?
Replies: 17
Views: 1517

Re: Methylene Blue Phase 3 failed?

OK, when you're ready let the conversation begin! The phase 2 trial with Methylene Blue looks solid. Methylene Blue is nearly a prehistoric medication. It predates the FDA! It was even used as a joke in medical schools due to its property of turning pee blue. It is FDA approved and has been given in...
by J11
Fri Dec 15, 2017 3:10 pm
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

Whenever any on this thread are ready we can transfer over to the "Did Methylene Blue fail?" thread to go over the research to date in excruciating line by line detail. We can start by reviewing the phase 2 trial. From my current understanding this trial demonstrated near conclusive eviden...
by J11
Thu Dec 14, 2017 6:27 pm
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

The only way might be for people to exercise their legal Right to Try. Methylene Blue is already on the market and a phase 2 trial has been published. This is sufficient for those interested to give it a try. How many Alzheimer patients would it take who had not progressed for 2 or more years before...
by J11
Thu Dec 14, 2017 10:40 am
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

Harrison, it was the LMTX phase 3s that became very confusing. I am not sure I remember it being this confusing 18 months ago when they decided to do the ole last minute switcheroo on the statistical data plan for the second phase 3 of LMTX and compare an apples treatment group to a 1000 pound super...
by J11
Wed Dec 13, 2017 9:58 pm
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

Julie G, the phase 2 trial did have some twists and turns. However, it was a large randomized trial that had proper placebo control. It found that there was a very large benefit to taking MB at a dose of 138 mg/day for up to 2 years. The first graph in the MB AD Cure Celebration Thread shows near st...
by J11
Wed Dec 13, 2017 9:49 pm
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

harrison, thank you for the clarification on the ASOs. I was quite surprised when reading the report on them on alzforum that even with the CAG repeats in the huntingtin protein they still were only able to knock down the overall protein expression and not the specifically pathogenic form. As a gues...
by J11
Wed Dec 13, 2017 9:36 pm
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

Tom, I was going for " Dementia research should not be more demented than those with dementia." though often the words just are not there for me. There are some highly accomplished writers on forums o one must always be careful. The problem is that I do not think anyone believe my excuse t...
by J11
Wed Dec 13, 2017 9:54 am
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

Tom, if you like you could post additional comments about MB to the "Did MB really fail?" thread. The big problem here is that oftentimes no one will do the required reading. Someone else is expected to do the leg work, though no one bothers. It appears that much of the reporting and comme...
by J11
Tue Dec 12, 2017 4:30 pm
Forum: Science and Research
Topic: From Huntington treatment to AD treatement?
Replies: 28
Views: 472

Re: From Huntington treatment to AD treatement?

Tom, I think one of the great features of this forum is that many here have taken the point of view that they are in charge of their health and they want to be fully educated about what their best options are. When you noted in your last post about "If they can get ..." it made me think of...

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