. Thank you, Nancy. It was brutal. I'd hoped to be able to slow her decline (in the beginning) to no avail (the family were highly uncooperative and, in fact, worked hard to convince my mom that I didn't know what I was doing). Ultimately, when mom died, the family blamed me for her rapid decline a...

Abstract Background The underlying mechanisms leading to dementia and Alzheimer’s disease (AD) are unclear. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be associated with cognitive decline, but population‐based evidence is lacking.... Hi Plumster, Were ...

An update: On July 12, 2023, my beloved mom died at the age of 74 due to rapidly advancing Alzheimer's (she went from stage 4 to 7 in just two years), severe osteoporosis, and multiple myeloma (which was diagnosed in July 2022). Literally no intervention could slow the tide of horror, every 3 month...

Hi- I haven't checked in for a long time, and I'm wondering how some of the posters from years ago are doing? I hate to be a downer, but are there some folks out there with long term success and how are they doing now? I would just love some reassurance that there really is hope out there. Thanks i...

I am an E3/E4 carrier in my 60s on HRT since start of menopause in my mid-50s. I have recently switched from continuous to cyclic (14 days/month) micronized progesterone (oral) with daily transdermal E2 gel. While the studies listed below are mouse models, the idea of cyclic progesterone makes sens...

This just came out April 9 as an Abstract only on April 9 in Neurology , (which has the catchphrase: "The most widely read and highly cited peer-reviewed neurology journal"). In a study of 194 people, median age 66, with a standard deviation of 10.7 years (so ages 55-77) with normal cognit...

NF52, Is this 2010 Finnish study trying to say their high ALZ rates are a function of (increased/improved) diagnostic reporting? I think it is saying two factors are affecting the prevalence rate: An increasing number of 90+ year olds, which they predicted in 2010 would increase the prevalence (ove...

... (see Finland's own reporting showing exploding ALZ rates over the last 40 years. Where is the critical thinking applied here to explain this disaster? The answer cannot simply be that Finnish people are living significantly longer than they were just 40 years ago or that molds are unique to Fin...

Just a quick question. If I have 2 APOE4 genes, but my brother doesn’t even have one, does this mean my parents only have one copy of the gene? I’m scared, but remain hopeful. Thank you! Hi Mich09! Genetics are confusing! We each have two copies of the ApoE gene (sometimes called an allele, or a va...

I should also note that I am apoe3/4... my mother's family all have high cholesterol, several of her relatives are on statins. My mother refused statins and is the one who got alzheimers. Yet she's also the one who got lupus, and I tend to think there may be some association with that. As for me, m...