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by NF52
Tue Apr 13, 2021 6:08 pm
Forum: Getting Started
Topic: Partner found out she's 4/4 - she's OK with it, I'm not
Replies: 3
Views: 71

Re: Partner found out she's 4/4 - she's OK with it, I'm not

... Of course, the results came back confirming that she is E4/E4. After a bit of initial confusion and reading, she is fairly blase about it. I (47) however am a natural worrier with a history of depression and anxiety, and lost my grandmother to Alzheimer's, and have been really struggling with t...
by NF52
Sun Apr 11, 2021 6:38 pm
Forum: Science and Research
Topic: Any updates on rs2075650 with APOE4/4 + family history?
Replies: 6
Views: 295

Re: Any updates on rs2075650 with APOE4/4 + family history?

I’m curious whether there’s new information on rs2075650 and its correlation with Alzheimer’s. Has anyone seen more recent info on rs2075650 and its impact on Alzheimer’s probabilities? I recently saw a slide in a genetics presentation showing that a Meta-analysis of studies indicate rs2075650 may ...
by NF52
Thu Apr 08, 2021 8:31 am
Forum: Getting Started
Topic: APOE 4/4 plus A673T
Replies: 6
Views: 150

Re: APOE 4/4 plus A673T

Hello ladies and gents, I have recently found out via My Heritage that I have two copies of the APOE 4 gene. So 4/4. Obviously giving me a "significantly increased risk" of developing late onset Alzheimer's disease. I have been doing some research in my raw DNA data and found a couple of ...
by NF52
Wed Apr 07, 2021 9:19 am
Forum: Science and Research
Topic: Targeting ApoE4 in mice removed plaques, improved blood vessels
Replies: 0
Views: 86

Targeting ApoE4 in mice removed plaques, improved blood vessels

This is another mouse story, but one that may prove important within a few years: Key Take-Away : HAE-4, an anti-ApoE antibody, mopped up plaques in a [humanized ApoE4] mouse model better than did the anti-amyloid antibody aducanumab. HAE-4 also cleared amyloid deposits from blood vessel walls, wher...
by NF52
Tue Apr 06, 2021 9:55 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 513
Views: 38694

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Setting up a unique strain of AD mice and seeing how they responded to amyloid treatment would certainly enhance the connection between research and those affected. Perhaps this will be more how people understand research in the future, especially if it turns out that every type of AD is its own sn...
by NF52
Tue Apr 06, 2021 7:23 am
Forum: Prevention and Treatment
Topic: Apollo Health supplements
Replies: 2
Views: 160

Re: Apollo Health supplements

Hello, What's the best way to buy Apollo Health supplements in Canada? I'm in the GTA (Greater Toronto Area) Thank you in advance Beegee HI Beegee, Have you tried contacting Apollo Health directly with this question? Because we're not affiliated with Apollo Health, members may not have the latest i...
by NF52
Tue Apr 06, 2021 7:19 am
Forum: Prevention and Treatment
Topic: Thoughts/reactions to the J&J covid vaccine?
Replies: 5
Views: 245

Re: Thoughts/reactions to the J&J covid vaccine?

I got my first Pfizer shot on Friday morning. I slept through Friday night, napped most of Saturday, and slept through Saturday night too. I never sleep that much! My arm also got pretty sore, but that’s gone as of today. Definitely better than winding up sick... I hope the second shot isn’t way wo...
by NF52
Tue Apr 06, 2021 7:13 am
Forum: Our Stories
Topic: Microbleed and white matter
Replies: 3
Views: 133

Re: Microbleed and white matter

Hiya, just wondering about this. I am a 61 year old woman and I know my eldest son is APOE4/4 Two years ago a MRI of my brain was made and they found white matter lesions and one microbleed. Doctor told me that everything was great and looked good and sent me away. But I am still wondering (and I t...
by NF52
Mon Apr 05, 2021 6:31 pm
Forum: Getting Started
Topic: Possible incomplete diagnosis
Replies: 3
Views: 173

Re: Possible incomplete diagnosis

My name is Bruce, my spouse is Louise. Louise was diagnosed with AD about a year ago.Also mentioned in the diagnosis was Capgras Syndrome, although that part of the diagnosis was barely mentioned. She is in treatment by a Bredesen approved doctor. I would call her dementia stable and relative mild....
by NF52
Sun Apr 04, 2021 9:38 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 513
Views: 38694

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

NF52, might you be able to provide some guidance? I think that I might have identified our very rare AD variant. I have contacted others on the genotyping platforms who potentially share the variant. Now that we have full genome sequencing on board it will be easier to clearly relate genotype to ph...

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