Search found 44 matches
- Wed Aug 04, 2021 2:35 pm
- Forum: Prevention and Treatment
- Topic: Great review of diet and ApoE4
- Replies: 1
- Views: 793
Great review of diet and ApoE4
From Harvard and Cornell https://www.mdpi.com/2072-6643/13/4/1362/htm The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer’s disease, a condition that is increasing in prevalence and remains without a cure. Precision nutrition targeting metabolic pathways altered by ApoE4 prov...
- Wed Aug 04, 2021 2:16 pm
- Forum: Science and Research
- Topic: Review: APOE gene variants in primary dyslipidemia
- Replies: 1
- Views: 507
Re: Review: APOE gene variants in primary dyslipidemia
That's a very thorough review. Like a lot of lipidology, you have to pay attention or get lost quickly.
- Tue Aug 03, 2021 3:22 pm
- Forum: Science and Research
- Topic: Riluzole trial is hopeful
- Replies: 3
- Views: 604
Re: Riluzole trial is hopeful
The mechanism of action is unclear. Initially it was thought to block glutamate release. Glutamate is an excitatory neurotransmitter and is plentiful in the brain. Excessive glutamate stimulation is thought to account for some of the toxicity of hypoxemia in the immediate aftermath of reoxygenation....
- Mon Aug 02, 2021 9:12 pm
- Forum: Science and Research
- Topic: Riluzole trial is hopeful
- Replies: 3
- Views: 604
Riluzole trial is hopeful
Riluzole is a medication that has been around quite a while and is generic. In this small trial there was a slowing in the progression of impaired brain glucose use, a primary focus of the study. There was also some sparing of cognitive decline compared to the placebo group. Riluzole can be purchase...
- Mon Aug 02, 2021 8:57 pm
- Forum: Science and Research
- Topic: Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analys
- Replies: 5
- Views: 1246
Re: Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal An
This is an association study only. It's a curious finding, for sure.
We don't know the mechanism for the group differences. There could be many possibilities.
We don't know the mechanism for the group differences. There could be many possibilities.
- Fri Jan 20, 2017 1:20 pm
- Forum: Science and Research
- Topic: CSF Ferritin predicts cognitive decline in E4s
- Replies: 115
- Views: 45616
Re: CSF Ferritin predicts cognitive decline in E4s
It's hard to know where to begin. But this is an important study. First, I don't see the value of checking the serum ferritin level. It does not tell you the brain iron status. Period. The only value it may have is if you were not sure it would be safe to decrease your iron intake. If the serum ferr...
- Wed Jan 11, 2017 1:38 pm
- Forum: Science and Research
- Topic: Scientific American interview with Dr. Fillit
- Replies: 3
- Views: 2074
Scientific American interview with Dr. Fillit
https://blogs.scientificamerican.com/talking-back/new-alzheimer-rsquo-s-treatments-offer-hope-despite-recent-drug-failures/?utm_source=Newsletter%2C+Donors%2C+Events%2C+General&utm_campaign=f5983f3cce-news17_1.11&utm_medium=email&utm_term=0_cc5f9da121-f5983f3cce-97061357&goal=0_cc5f9...
- Mon Jan 09, 2017 5:17 pm
- Forum: Science and Research
- Topic: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
- Replies: 10
- Views: 4447
Re: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
I have to agree with all you said, Stavia.
I have a collection of a few dozen courses. There hasn't been a disappointment yet.
I have a collection of a few dozen courses. There hasn't been a disappointment yet.
- Mon Jan 09, 2017 10:40 am
- Forum: Science and Research
- Topic: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
- Replies: 10
- Views: 4447
Re: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
So the idea may be to find something challenging and engaging without engendering fear of failure. Learning a musical instrument is a possibility, especially if you don't mind never amounting to much with it. Another approach I enjoy is watching lectures from The Great Courses. http://www.thegreatco...
- Sun Jan 08, 2017 9:35 am
- Forum: Prevention and Treatment
- Topic: Melatonin
- Replies: 45
- Views: 16170
Re: Melatonin
Here are a few comments. Cortisol levels should be at their peak in the morning. Sleep apnea, chronic insomnia and a longer fast can elevate them. And the normal for an individual can vary a lot. Lots of possibilities. Controlled studies of melatonin for chronic insomnia show only a small benefit. T...