Search found 44 matches

by marty
Wed Aug 04, 2021 2:35 pm
Forum: Prevention and Treatment
Topic: Great review of diet and ApoE4
Replies: 1
Views: 793

Great review of diet and ApoE4

From Harvard and Cornell https://www.mdpi.com/2072-6643/13/4/1362/htm The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer’s disease, a condition that is increasing in prevalence and remains without a cure. Precision nutrition targeting metabolic pathways altered by ApoE4 prov...
by marty
Wed Aug 04, 2021 2:16 pm
Forum: Science and Research
Topic: Review: APOE gene variants in primary dyslipidemia
Replies: 1
Views: 507

Re: Review: APOE gene variants in primary dyslipidemia

That's a very thorough review. Like a lot of lipidology, you have to pay attention or get lost quickly.
by marty
Tue Aug 03, 2021 3:22 pm
Forum: Science and Research
Topic: Riluzole trial is hopeful
Replies: 3
Views: 604

Re: Riluzole trial is hopeful

The mechanism of action is unclear. Initially it was thought to block glutamate release. Glutamate is an excitatory neurotransmitter and is plentiful in the brain. Excessive glutamate stimulation is thought to account for some of the toxicity of hypoxemia in the immediate aftermath of reoxygenation....
by marty
Mon Aug 02, 2021 9:12 pm
Forum: Science and Research
Topic: Riluzole trial is hopeful
Replies: 3
Views: 604

Riluzole trial is hopeful

Riluzole is a medication that has been around quite a while and is generic. In this small trial there was a slowing in the progression of impaired brain glucose use, a primary focus of the study. There was also some sparing of cognitive decline compared to the placebo group. Riluzole can be purchase...
by marty
Mon Aug 02, 2021 8:57 pm
Forum: Science and Research
Topic: Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analys
Replies: 5
Views: 1246

Re: Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal An

This is an association study only. It's a curious finding, for sure.

We don't know the mechanism for the group differences. There could be many possibilities.
by marty
Fri Jan 20, 2017 1:20 pm
Forum: Science and Research
Topic: CSF Ferritin predicts cognitive decline in E4s
Replies: 115
Views: 45616

Re: CSF Ferritin predicts cognitive decline in E4s

It's hard to know where to begin. But this is an important study. First, I don't see the value of checking the serum ferritin level. It does not tell you the brain iron status. Period. The only value it may have is if you were not sure it would be safe to decrease your iron intake. If the serum ferr...
by marty
Wed Jan 11, 2017 1:38 pm
Forum: Science and Research
Topic: Scientific American interview with Dr. Fillit
Replies: 3
Views: 2074

Scientific American interview with Dr. Fillit

https://blogs.scientificamerican.com/talking-back/new-alzheimer-rsquo-s-treatments-offer-hope-despite-recent-drug-failures/?utm_source=Newsletter%2C+Donors%2C+Events%2C+General&utm_campaign=f5983f3cce-news17_1.11&utm_medium=email&utm_term=0_cc5f9da121-f5983f3cce-97061357&goal=0_cc5f9...
by marty
Mon Jan 09, 2017 5:17 pm
Forum: Science and Research
Topic: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
Replies: 10
Views: 4447

Re: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...

I have to agree with all you said, Stavia.

I have a collection of a few dozen courses. There hasn't been a disappointment yet.
by marty
Mon Jan 09, 2017 10:40 am
Forum: Science and Research
Topic: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
Replies: 10
Views: 4447

Re: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...

So the idea may be to find something challenging and engaging without engendering fear of failure. Learning a musical instrument is a possibility, especially if you don't mind never amounting to much with it. Another approach I enjoy is watching lectures from The Great Courses. http://www.thegreatco...
by marty
Sun Jan 08, 2017 9:35 am
Forum: Prevention and Treatment
Topic: Melatonin
Replies: 45
Views: 16170

Re: Melatonin

Here are a few comments. Cortisol levels should be at their peak in the morning. Sleep apnea, chronic insomnia and a longer fast can elevate them. And the normal for an individual can vary a lot. Lots of possibilities. Controlled studies of melatonin for chronic insomnia show only a small benefit. T...