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by marty
Mon Aug 02, 2021 9:12 pm
Forum: Science and Research
Topic: Riluzole trial is hopeful
Replies: 0
Views: 4

Riluzole trial is hopeful

Riluzole is a medication that has been around quite a while and is generic. In this small trial there was a slowing in the progression of impaired brain glucose use, a primary focus of the study. There was also some sparing of cognitive decline compared to the placebo group. Riluzole can be purchase...
by marty
Mon Aug 02, 2021 8:57 pm
Forum: Science and Research
Topic: Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal Analys
Replies: 5
Views: 322

Re: Apolipoprotein E Genotype, Meat, Fish, and Egg Intake in Relation to Mortality Among Older Adults: A Longitudinal An

This is an association study only. It's a curious finding, for sure.

We don't know the mechanism for the group differences. There could be many possibilities.
by marty
Fri Jan 20, 2017 1:20 pm
Forum: Science and Research
Topic: CSF Ferritin predicts cognitive decline in E4s
Replies: 115
Views: 36094

Re: CSF Ferritin predicts cognitive decline in E4s

It's hard to know where to begin. But this is an important study. First, I don't see the value of checking the serum ferritin level. It does not tell you the brain iron status. Period. The only value it may have is if you were not sure it would be safe to decrease your iron intake. If the serum ferr...
by marty
Wed Jan 11, 2017 1:38 pm
Forum: Science and Research
Topic: Scientific American interview with Dr. Fillit
Replies: 3
Views: 1712

Scientific American interview with Dr. Fillit

https://blogs.scientificamerican.com/talking-back/new-alzheimer-rsquo-s-treatments-offer-hope-despite-recent-drug-failures/?utm_source=Newsletter%2C+Donors%2C+Events%2C+General&utm_campaign=f5983f3cce-news17_1.11&utm_medium=email&utm_term=0_cc5f9da121-f5983f3cce-97061357&goal=0_cc5f9...
by marty
Mon Jan 09, 2017 5:17 pm
Forum: Science and Research
Topic: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
Replies: 10
Views: 3614

Re: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...

I have to agree with all you said, Stavia.

I have a collection of a few dozen courses. There hasn't been a disappointment yet.
by marty
Mon Jan 09, 2017 10:40 am
Forum: Science and Research
Topic: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...
Replies: 10
Views: 3614

Re: Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks...

So the idea may be to find something challenging and engaging without engendering fear of failure. Learning a musical instrument is a possibility, especially if you don't mind never amounting to much with it. Another approach I enjoy is watching lectures from The Great Courses. http://www.thegreatco...
by marty
Sun Jan 08, 2017 9:35 am
Forum: Prevention and Treatment
Topic: Melatonin
Replies: 45
Views: 13033

Re: Melatonin

Here are a few comments. Cortisol levels should be at their peak in the morning. Sleep apnea, chronic insomnia and a longer fast can elevate them. And the normal for an individual can vary a lot. Lots of possibilities. Controlled studies of melatonin for chronic insomnia show only a small benefit. T...
by marty
Sun Jan 08, 2017 9:13 am
Forum: Prevention and Treatment
Topic: Melatonin
Replies: 45
Views: 13033

Re: Melatonin

I can't comment on Consumer Lab specifically. It may be credible. Beware that some "labs" are non-existent or are paid by the manufacturing or importing company for an endorsement. If there is advertising on the website that says it did the analysis, be very suspicious. Another concern is ...
by marty
Sun Jan 08, 2017 9:03 am
Forum: Our Stories
Topic: Neurologist and a 4/4
Replies: 19
Views: 5752

Re: Neurologist and a 4/4

Pretty much all major studies have confidentiality agreements to limit divulgence of design of the study. There are different reasons for this, but one of them is to prevent competing groups from unfair advantage. There are egos, patents, and money involved, like in most human endeavors. What I can ...
by marty
Fri Jan 06, 2017 3:01 pm
Forum: Science and Research
Topic: Mind your ApoA1 levels!
Replies: 21
Views: 6605

Re: Mind your ApoA1 levels!

[quote="Juliegee"]Marty, many of us are following the cardiovascular angle too. So far, it looks though pharmaceutically induced higher HDL levels are of little to no value. For now, looks like HDL has to be earned the old fashioned way. The relationship between HDL and neurodegeneration i...

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