I was looking at APOE3/4 risk for women based on 23andme statistics which I just started checking out today. However, correct me if I'm wrong, but it doesn't seem like the APOE3/4 statistics for women (which are more susceptible to AD than men) are particularly alarming. At least I hope I'm reading ...

Hi guys, just wanted to ask, regardless of APOE4 status (which I may or may not have given it seems to be present in my family), how lifestyle/diet changes can remedy past choices. So in my case for 10 years of my life I was completely sedentary, ate lots of junk food, gained weight (was overweight)...

Thanks MAC. Of course every individual is different, but in the Western world, assuming the life expectancy for men/women is around 76 to 81 (respectively), what would you estimate the AVERAGE life expectancy for an APOE3/4 carrier would be? What I'm trying to understand is - when people say APOE4 h...

I have been looking up material on the influence of ApoE4 on average life expectancy, especially on South Europeans (given that is my family's heritage), and the evidence is CONFUSING and contradictory to say the least! I have found studies with EVERY KIND of conflicting evidence - studies claiming ...

Similarly, isn't it true that Alzheimer rates are lower in certain countries than others? Meaning the percentage increase of APOE4 has a greater/lower "real" effect in certain countries. For instance, in places like the US and North Europe, roughly 8% of >65 year olds have Alzheimer's. If ...

Since people here seem to be better experts at SNPs than I am, I was hoping you could answer one of my queries. There is a supposed SNP (rs1799724), which, according to Promethease and SNPedia, when combined with an APOE3/4 score, raises the risk of AD from 3x to 6-7x. This claim was based on a stud...

He got it from a testing company, I forgot which one. Not 23andme, though. What I'm asking is if there are any specific APOE4 tests which could be done on multiple people in the family. Ordering a 23andme for 3 or 4 people just to find out their APOE4 seems like a bit of a waste of time and money. A...

Thanks. I have found this website on your Wiki that seems to have relatively reasonable prices for tests (in the $50-100 range, compared to some others I found that can even be as much as $500). However, I don't understand how it works: it isn't clear to me if this is a genetic testing site or if it...

Unfortunately he was not tested on rs429358. All he knows is that he is CC for rs7412. I am trying to figure out what his rs429358 score would be, which is why I am looking at proxies. Of the four best rs429348 proxies, he has the risk allele in one of them (rs4420638), but doesn't in the other thre...

Hi everyone, I wanted to test some family members for the APOE-4 mutation by an online test. Are there any non-23andme tests which are accurate and provide information on whether the person carries the APOE-4 mutation? I am struggling to find them online, if anyone can help me find one that would be...