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by Fiver
Fri Sep 18, 2020 8:33 am
Forum: Science and Research
Topic: apoe2, while protective on its own, doesn't cancel out apoe4
Replies: 2
Views: 566

apoe2, while protective on its own, doesn't cancel out apoe4

New article in Nature: https://www.nature.com/articles/s41467-020-18198-x

Interesting....apoe2/4 had outcomes similar to apoe4/4, i.e. the 2, while protective on its own, can't cancel out the 4.
by Fiver
Sun Aug 30, 2020 4:10 pm
Forum: Our Stories
Topic: Anxious and fearful
Replies: 10
Views: 793

Re: Anxious and fearful

Hi Chronophylos, you and I have some things in common. Similar ages, occupations, risk factors, and worries. As for your feelings about your apoe4 genes, it is totally natural to feel this way. I felt the same. Many of us did, or still do. It really is a roller coaster of a journey. In terms of the ...
by Fiver
Tue Aug 25, 2020 12:47 pm
Forum: Our Stories
Topic: Need some guidance
Replies: 5
Views: 468

Re: Need some guidance

Hi LC-FL, A few things come to mind, which might be helpful. PS - I'm not a doctor. Tincup is right about blood sugar control being something to look at, and it's something you can address now. If he recently retired maybe he is not as active and constantly training for work. Maye he can find someth...
by Fiver
Wed Aug 19, 2020 10:12 am
Forum: Science and Research
Topic: 4 drugs which may get approval in 3-5 years
Replies: 3
Views: 986

Re: 4 drugs which may get approval in 3-5 years

very interesting and helpful! Thanks. I little bit of good news for my day. :)
by Fiver
Wed May 27, 2020 9:09 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 3095

Re: Alzheimer's Afternoons Seminar Series Summaries

Good question. I noticed some differences too. I don't know the specific answer for their studies but overall the researchers are using different models - usually mice, but often different strains - in different ways. The iPSC cells can be different, even different cell types. Sometimes the cells ar...
by Fiver
Wed May 27, 2020 9:03 am
Forum: Science and Research
Topic: APOE4 protective against melanoma
Replies: 1
Views: 450

Re: APOE4 protective against melanoma

Hi BrianR, I also saw this one: https://www.nature.com/articles/s41591-020-0879-3 Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depleti...
by Fiver
Fri May 15, 2020 7:54 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 3095

Re: Alzheimer's Afternoons Seminar Series Summaries

Dr. Elizabeth Head, Professor, University of California Irvine Alzheimer’s disease in Down syndrome: Link between Cerebrovascular pathology On Thursday, May 14, 2020 Dr. Liz Head presented her work on Alzheimer’s disease in Down Syndrome. Why would it be useful to study the pathology of AD that is a...
by Fiver
Thu May 14, 2020 3:40 pm
Forum: Prevention and Treatment
Topic: PREPRINT: Increased risk from COVI-19 in apoe4s
Replies: 10
Views: 1961

Re: PREPRINT: Increased risk from COVI-19 in apoe4s

Yep. I agree. I expected it too. Still, it seems like piling on.
by Fiver
Thu May 14, 2020 12:55 pm
Forum: Prevention and Treatment
Topic: PREPRINT: Increased risk from COVI-19 in apoe4s
Replies: 10
Views: 1961

PREPRINT: Increased risk from COVI-19 in apoe4s

https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1 Full text: https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1.full.pdf+html APOE E4 GENOTYPE PREDICTS SEVERE COVID-19 IN THE UK BIOBANK COMMUNITY COHORT View ORCID ProfileChia-Ling Kuo, View ORCID ProfileLuke C Pilling, View OR...
by Fiver
Tue May 05, 2020 9:58 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 3095

Re: Alzheimer's Afternoons Seminar Series Summaries

Yep. There seems to to be several things going on with blood vessels - hardening, unresponsiveness, cerebral coronary amyloidosis, leakiness of the blood brain barrier. And apoe4 seems to contribute to most if not all of them. :(

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