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by Fiver
Wed May 27, 2020 9:09 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2288

Re: Alzheimer's Afternoons Seminar Series Summaries

Good question. I noticed some differences too. I don't know the specific answer for their studies but overall the researchers are using different models - usually mice, but often different strains - in different ways. The iPSC cells can be different, even different cell types. Sometimes the cells ar...
by Fiver
Wed May 27, 2020 9:03 am
Forum: Science and Research
Topic: APOE4 protective against melanoma
Replies: 1
Views: 299

Re: APOE4 protective against melanoma

Hi BrianR, I also saw this one: https://www.nature.com/articles/s41591-020-0879-3 Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depleti...
by Fiver
Fri May 15, 2020 7:54 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2288

Re: Alzheimer's Afternoons Seminar Series Summaries

Dr. Elizabeth Head, Professor, University of California Irvine Alzheimer’s disease in Down syndrome: Link between Cerebrovascular pathology On Thursday, May 14, 2020 Dr. Liz Head presented her work on Alzheimer’s disease in Down Syndrome. Why would it be useful to study the pathology of AD that is a...
by Fiver
Thu May 14, 2020 3:40 pm
Forum: Prevention and Treatment
Topic: PREPRINT: Increased risk from COVI-19 in apoe4s
Replies: 10
Views: 1457

Re: PREPRINT: Increased risk from COVI-19 in apoe4s

Yep. I agree. I expected it too. Still, it seems like piling on.
by Fiver
Thu May 14, 2020 12:55 pm
Forum: Prevention and Treatment
Topic: PREPRINT: Increased risk from COVI-19 in apoe4s
Replies: 10
Views: 1457

PREPRINT: Increased risk from COVI-19 in apoe4s

https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1 Full text: https://www.medrxiv.org/content/10.1101/2020.05.07.20094409v1.full.pdf+html APOE E4 GENOTYPE PREDICTS SEVERE COVID-19 IN THE UK BIOBANK COMMUNITY COHORT View ORCID ProfileChia-Ling Kuo, View ORCID ProfileLuke C Pilling, View OR...
by Fiver
Tue May 05, 2020 9:58 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2288

Re: Alzheimer's Afternoons Seminar Series Summaries

Yep. There seems to to be several things going on with blood vessels - hardening, unresponsiveness, cerebral coronary amyloidosis, leakiness of the blood brain barrier. And apoe4 seems to contribute to most if not all of them. :(
by Fiver
Mon May 04, 2020 8:42 am
Forum: Science and Research
Topic: Apoe4 leads to BBB disfunction
Replies: 3
Views: 629

Re: Apoe4 leads to BBB disfunction

Hi Stefan. I have to read this one soon. I'll see what I can access and share.
by Fiver
Mon May 04, 2020 8:40 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2288

Re: Alzheimer's Afternoons Seminar Series Summaries

Sex differences in metabolic and vascular contributions to dementia. April 30, 2020 Dr. Kristen Zuloaga is an Associate Professor of Neuroscience and Experimental Therapeutics (DNET) at Albany Medical College. A list of her group’s recent publications can be found here: http://www.zuloagalab.com/pu...
by Fiver
Thu Apr 30, 2020 8:45 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2288

Re: Alzheimer's Afternoons Seminar Series Summaries

Alzheimer’s Afternoon Seminar Series Dr. Shannon Macauley April 28, 2020 Targeting vascular KATP channel activity in Alzheimer's disease Takeaway: Sulfonylurea drugs used to treat diabetes seem to inhibit the accumulation of Aβ by restoring vascular health and calming neuronal activity in the brain...
by Fiver
Fri Apr 24, 2020 8:00 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2288

Re: Alzheimer's Afternoons Seminar Series Summaries

Alzheimer’s Afternoon Seminar Series APP and Bioenergetics Dr. Heather Wilkins, University of Kansas Medical Center April 23, 2020 Takeaway: The process of degrading old, malfunctioning mitochondria and replacing them with young, healthy mitochondria is important but slows with age (perhaps more in ...

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