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by Fiver
Wed Oct 16, 2019 7:44 am
Forum: Prevention and Treatment
Topic: Review article on AD risk factors: so many studies, so many conflicting or inconclusive results
Replies: 5
Views: 452

Re: Review article on AD risk factors: so many studies, so many conflicting or inconclusive results

Yes, it's frustrating. Incomplete data about what works, for who, and at what ages. Few practical ways to monitor our status to know if our efforts are working. And unnecessary challenges for arranging long-term care and making end-of-life decisions. I agree. But we can address these issues by aggre...
by Fiver
Fri Oct 11, 2019 11:11 am
Forum: Prevention and Treatment
Topic: Risk Factor Question - Family History
Replies: 6
Views: 328

Re: Risk Factor Question - Family History

That is my understanding also. Not great for me, but good for you!
by Fiver
Fri Oct 11, 2019 7:02 am
Forum: Prevention and Treatment
Topic: U.S. surgeons general: Dementia is our top public health crisis | Commentary
Replies: 3
Views: 199

Re: U.S. surgeons general: Dementia is our top public health crisis | Commentary

I agree! From talking with doctors in my area it seems like they need a pre-packaged screening program to order for patients, where they get a report with recommendations. Maybe a set of blood tests, a questionare, and a cognitive test where a program scores them and generates a report. And recommen...
by Fiver
Thu Oct 10, 2019 9:29 am
Forum: Prevention and Treatment
Topic: U.S. surgeons general: Dementia is our top public health crisis | Commentary
Replies: 3
Views: 199

U.S. surgeons general: Dementia is our top public health crisis | Commentary

Today's article from past US Surgeons General: https://www.orlandosentinel.com/opinion/guest-commentary/os-op-dementia-crisis-surgeons-general-20191010-xrunvqs4tbhavfjqdkcsvxvn3u-story.html Despite these staggering numbers, dementia remains little understood — when it’s not misunderstood — and garne...
by Fiver
Mon Sep 30, 2019 7:47 am
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 1907

Re: Epigenetics - can we really turn APOE4 off?

In terms of how expression of the apoe4 gene could be manipulated the options would be indirect (changing methylation of nearby DNA or acetylation of nearby histones, small RNA which are poorly understood) or direct (anti-sense DNA silencing, RNA destruction, protein destruction). But it's still not...
by Fiver
Wed Sep 25, 2019 7:01 am
Forum: Science and Research
Topic: Clusterin / ApoJ
Replies: 2
Views: 261

Re: Clusterin / ApoJ

Thanks for sharing this! I won't get to read it until things settle down here, but I am interested.
by Fiver
Wed Sep 18, 2019 1:46 pm
Forum: Science and Research
Topic: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease
Replies: 6
Views: 302

Re: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease

I'd like to think that too! I am a big fan of plant polyphenols. I'd love it if they were a part of the solution. I think it's going to take some time before we know for certain if we can alter methylation in a useful way with lifestyle. These techniques are pretty cutting-edge. I'm not aware that t...
by Fiver
Wed Sep 18, 2019 7:43 am
Forum: Science and Research
Topic: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease
Replies: 6
Views: 302

Re: Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease

Wow. That's a very interesting and VERY dense paper! I think I could spend all week reading this one to really understand it. Basically, the researchers looked at cells with genes known to trigger early onset AD and other cells with the apoe4 genes contributing to late onset AD, comparing them to v...
by Fiver
Fri Sep 13, 2019 12:10 pm
Forum: Prevention and Treatment
Topic: Cleaning of Lymphatic brain vessel - Nasya therapy
Replies: 20
Views: 916

Re: Cleaning of Lymphatic brain vessel - Nasya therapy

Thanks. very interesting! I think this is what I am learning: Looks like several things might be going on. Cell shrink and swell, which would involve the aquaporins to let water in and out of cells. Then there is some sort of space, tubes or openings. And these become more open or more constricted d...
by Fiver
Thu Sep 12, 2019 8:40 am
Forum: Prevention and Treatment
Topic: UsAgainstAlzheimers report: non-pharmacological interventions
Replies: 2
Views: 235

Re: UsAgainstAlzheimers report: non-pharmacological interventions

Thanks Julie. That's also a interesting site. (when I saw that they list statins as having solid evidence supporting moderate benefit I imagined the debate that might cause, though it does seem - at least to me - to be an accurate rating). It is interesting what happens in society as evidence for no...

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