Hi AnnieV, I appreciate your thinking. That the body evolved to function optimally and rest is up to us, to treat it well by eating right and living right. I spend a lot of time trying to do that myself, and I sure do hope it’s helping. It’s probably my training that causes me to think of evolution ...

Hi everyone. I find all the trends and patterns fascinating and, like others, I look for useful clues there. Thanks for sharing those studies. But I keep coming but to the thought that I'm not sure it matters if apoe4 was or was not once beneficial, or if there are differences in risk across the glo...

-Have you ever measured your homocysteine? That's an important biomarker to track as it's associated with cognitive decline, brain atrophy, white matter hyper intensities, etc. Most of us end up needing to supplement B-12, folate and B6 (as P5P). Below is a quote homocysteine from "Breaking Al...

Oh are you a mouth breather too? :) Does taping work? Yes, absolutely! About six years ago, just as I was entering menopause and my estrogen was dropping, I started having severe sleep problems and would wake up many times a night. I started myofunctional therapy and joined a breathing clinic, and ...

Hi Julie, Thanks for your message. I hope all is well. -E4, in a dose dependent fashion, has been shown to impair the brain's ability to effectively use glucose — hence the importance of getting into ketosis at least once daily (1.0-1.5 mM), not chronically. (Read more here. ) Have you ever measured...

Hi Plumster, thanks for sharing your plan. Whole foods plant based diet low fat, low sugar At various times, sometime lasting for years, I've done the Med Diet and ketoflex variations, with or without 16h fasting. Recently I've been really convinced that ketogenic diets have good benefits, so I went...

Hi everyone, I hope all is well. Anyone want to talk about prevention strategies? Here’s mine: Fish oil, vitamin D, atorvastatin 10mg sulforaphane and sodium butyrate, hoping these HDAC inhibitors fix endosomal/lysosomal cycling. Tried homotaurine for a while, would like to restart that. A generally...

Hi. I was just reading these. Seems like an opportunity for RNAi or using an antibody (which can get through the BBB) to shut apoe4 down. Sign me up!

Good points. It makes me think that's a potential problem. With the animal models we can run large, controlled, multi-factorial experiments - that's great! Then we try to repeat that with people and it's impossible to have those type of tightly-controlled conditions and sample sizes. But we're so us...

Thanks for sharing this! Over the years I've wondered why clinical trial results were so unclear most of the time, compared to the earlier studies in animals or cell cultures, where the results are usually clear. Sample sizes, I suppose, and the fact that animals cooperate better, and can't drop out...