Search found 629 matches

by Fiver
Mon Mar 25, 2024 5:07 pm
Forum: Prevention and Treatment
Topic: Methylene Blue: OLE results from Lucidity Trial at Lisbon AD/PD
Replies: 2
Views: 121

Re: Methylene Blue: OLE results from Lucidity Trial at Lisbon AD/PD

Thanks for sharing this! Over the years I've wondered why clinical trial results were so unclear most of the time, compared to the earlier studies in animals or cell cultures, where the results are usually clear. Sample sizes, I suppose, and the fact that animals cooperate better, and can't drop out...
by Fiver
Tue Mar 12, 2024 8:32 am
Forum: Announcements and Events
Topic: Alzheon ALZ-801 results presentations tomorrow
Replies: 8
Views: 662

Re: Alzheon ALZ-801 results presentations tomorrow

It's still really interesting, and certainly enough to warrant the P3 trial. Thanks for sharing it. I find those abstracts very interesting and try to read into the phrasing to see if I can guess more about the data. But I guess we'll just need to be patient for the P3 results. Unless someone can co...
by Fiver
Mon Mar 11, 2024 9:52 am
Forum: Announcements and Events
Topic: Alzheon ALZ-801 results presentations tomorrow
Replies: 8
Views: 662

Re: Alzheon ALZ-801 results presentations tomorrow

Thinking more. A few of these statements leave me with questions: "Plasma p-tau181 showed significant reductions at all timepoints with 31% at 104 weeks (p=0.045), plasma Aβ42 decreased ~4% over 104 weeks (p=0.042), and hippocampus showed 3.6% atrophy that is ~28% less than matched ADNI subject...
by Fiver
Mon Mar 11, 2024 8:27 am
Forum: Announcements and Events
Topic: Alzheon ALZ-801 results presentations tomorrow
Replies: 8
Views: 662

Re: Alzheon ALZ-801 results presentations tomorrow

Thanks NF52. :D That's interesting, and promising. I feel like once we have a few interventions that work a bit, we could start using them in combination for stronger outcomes and then we'd be making good progress.
by Fiver
Sat Mar 09, 2024 9:14 am
Forum: Announcements and Events
Topic: Alzheon ALZ-801 results presentations tomorrow
Replies: 8
Views: 662

Re: Alzheon ALZ-801 results presentations tomorrow

Thanks so much for the news. I wish I could be there to hear these results! I notice on the website you linked there is a press release describing the various talks and posters related to these studies. Let's hope the actual results get reported out in print soon.
by Fiver
Mon Feb 19, 2024 12:40 pm
Forum: Prevention and Treatment
Topic: Modifiable risks and APOE 4/4
Replies: 7
Views: 670

Re: Modifiable risks and APOE 4/4

It can be frustrating. It's hard to know for sure what modifiable risk factors to focus on since there isn't an easy way to check our progress and revise our approach. Following the general guidelines arising from research trials is the best approach we have right now. Luckily for us most of the int...
by Fiver
Fri Feb 09, 2024 7:07 am
Forum: Science and Research
Topic: Question about new research on lysosomal autophagy
Replies: 2
Views: 329

Re: Question about new research on lysosomal autophagy

Thanks for sharing this article. The endosomal/lysosomal system for taking molecules into the cell, releasing the useful ones, and digesting the rest is disrupted by apoe4. It creates a bit of a traffic jam there. If these hypothetical drugs fix the structure of apoe4 and gets this system flowing ag...
by Fiver
Tue Jan 30, 2024 1:28 pm
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 347429

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

Hi everyone. I hope you're all well. Life is busy and I mostly stay in the background these days, though I continue to work in a closely-related field and I do read this site regularly. I agree with Julie about the need to look upstream from amyloid and tau, especially for E4s. It's so challenging t...
by Fiver
Tue Jan 09, 2024 8:49 am
Forum: Science and Research
Topic: Homotaurine (tramiprosate) appears to be a structure corrector
Replies: 77
Views: 131842

Re: Homotaurine (tramiprosate) appears to be a structure corrector

Hi Veero. Thanks for reminding me of that. I'm hoping it stops eventually. I'd prefer to see one thing at a time. ;)