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by TheBrain
Wed May 27, 2020 5:46 am
Forum: Science and Research
Topic: Does having APOE4 protect you from getting the Coronavirus? .... Maybe
Replies: 27
Views: 4299

Re: Does having APOE4 protect you from getting the Coronavirus? .... Maybe

Depressing news, but I’d rather know than not know.
by TheBrain
Thu Apr 23, 2020 5:17 am
Forum: Prevention and Treatment
Topic: Dutch Woman With Dementia Euthanized Against Her Will. The Doctor Was Just Cleared Of Wrongdoing.
Replies: 26
Views: 3399

Re: Dutch Woman With Dementia Euthanized Against Her Will. The Doctor Was Just Cleared Of Wrongdoing.

It seems the case in the original post has been clarified in the courts: Dutch court allows euthanasia in advanced dementia cases Thanks, circular. The original reporting contradicts what’s stated in the latest article (the first page contains the link for this thread): And in the case of this spec...
by TheBrain
Wed Apr 22, 2020 12:57 pm
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 9
Views: 1014

Re: How do specificity and sensitivity work with lab testing?

Tincup wrote:One thing to note, with a 1% prevalence, if you test false, the probability that you've not had the bug is very near 100%. In my 1 million case example. There are only 100 false negatives out of nearly 1 million.


Thanks for this and your previous post. My head has finally wrapped this matter.
by TheBrain
Wed Apr 22, 2020 12:56 pm
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 9
Views: 1014

Re: How do specificity and sensitivity work with lab testing?

I found Peter Attia's explanation and modifiable spread sheet helpful. The accuracy of lab tests depends on how common the condition is in the community (prevalence). Thanks, Slacker. I didn't see your post until I submitted my response to Tincup. I'll take a look. Great video! Peter Attia explains...
by TheBrain
Wed Apr 22, 2020 8:49 am
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 9
Views: 1014

Re: How do specificity and sensitivity work with lab testing?

slacker wrote:I found Peter Attia's explanation and modifiable spread sheet helpful. The accuracy of lab tests depends on how common the condition is in the community (prevalence).


Thanks, Slacker. I didn't see your post until I submitted my response to Tincup. I'll take a look.
by TheBrain
Wed Apr 22, 2020 8:46 am
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 9
Views: 1014

Re: How do specificity and sensitivity work with lab testing?

I did the exercise here (see table in link) with this result, and Birx did not misspeak. The issue is the assumption is that 1% are positive AND you are testing everyone. I randomly assumed a grand total of 1,000,000. I used the 99% assumptions. Header Disease_Present Disease_Absent Totals Test_Pos...
by TheBrain
Wed Apr 22, 2020 6:06 am
Forum: Science and Research
Topic: How do specificity and sensitivity work with lab testing?
Replies: 9
Views: 1014

How do specificity and sensitivity work with lab testing?

I wasn’t sure where to post this, as it’s related to COVID-19, but I believe my question applies more broadly about lab tests. Below is the article that raises the question for me. I understand that specificity and sensitivity relate to false negatives and false positives. We don’t want either. I’ve...
by TheBrain
Wed Apr 22, 2020 4:38 am
Forum: Science and Research
Topic: KLOTHO: Good news for 20% of us!
Replies: 11
Views: 1929

Re: KLOTHO: Good news for 20% of us!

23andme showed I’m homozygous on the first SNP. It didn’t show the second SNP, but I guess I can assume it’s also homozygous.
by TheBrain
Tue Apr 07, 2020 8:55 am
Forum: Science and Research
Topic: New series of very interesting articles on APOE4
Replies: 2
Views: 1289

Re: New series of very interesting articles on APOE4

Wow, and all 11 articles are downloadable at no charge. Fiver, thanks for posting this!
by TheBrain
Tue Apr 07, 2020 8:44 am
Forum: Prevention and Treatment
Topic: podcast: Gastropod: Can Diet Stop Alzheimer’s?
Replies: 3
Views: 1405

Re: podcast: Gastropod: Can Diet Stop Alzheimer’s?

Thanks, Brian. I look forward to a listen. I was an early fan of Lisa Mosconi; even got to have lunch with her and Stephan Cunane in NY, but have been largely disappointed with her diet recommendations. She has a good handle on the reduction in cerebral glucose utilization issues for our genotype (...

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