Search found 27 matches

by MichaelR
Mon Aug 03, 2020 10:32 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 73
Views: 38222

Re: Using RAPA for AD prevention

I decided not to take rapamycin ... mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR rhythms of the body (lower – though not in all tissues – at night; higher during...
by MichaelR
Sat Aug 01, 2020 4:13 pm
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 73
Views: 38222

Re: Using RAPA for AD prevention

I have read some newer articles with "low dose rapamycin," as low as 0.5 mg/kg in mice I'd like to see that 0.5 mg/kg study; please link or cite. In PMID 24341993 , 0.75 mg/kd per day of rapa had no effect on lifespan in male mice, and only a modest effect in females (who get higher blood...
by MichaelR
Thu Dec 13, 2018 4:03 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 11806

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

In terms of the worries about apoE production in neurons vs. astrocytes and CNS vs. periphery, and therefore benign functions of apoEε4 that might be buggered up by structure correctors or other approaches: this doesn't seem to have been posted: A 40-year-old African American man was referred to the...
by MichaelR
Fri May 11, 2018 11:53 am
Forum: Science and Research
Topic: Pilot Trial finds Ketogenic Diet Beneficial in Mild AD
Replies: 3
Views: 1959

Re: Pilot Trial finds Ketogenic Diet Beneficial in Mild AD

I was interested to see how the caregivers really seemed to struggle with a keto diet in the moderate rather than mild group, and how cooking lessons seemed to help- I got the feeling this was more than a study based simply on capsules or feeding a supplementary drink. Well, it clearly wasn't based...
by MichaelR
Thu May 10, 2018 12:50 pm
Forum: Science and Research
Topic: Pilot Trial finds Ketogenic Diet Beneficial in Mild AD
Replies: 3
Views: 1959

Pilot Trial finds Ketogenic Diet Beneficial in Mild AD

After I just got through saying that there has yet to be a trial of ketogenic diets or supplements to show a clear positive effect in AD patients or people at high risk: Alzheimer's & Dementia: Translational Research & Clinical Interventions Volume 4, 2018, Pages 28-36 Feasibility and effica...
by MichaelR
Thu May 10, 2018 12:08 pm
Forum: Science and Research
Topic: Ketogenic Supplement Tricaprilin Fails in AD Trial
Replies: 21
Views: 8529

Re: Ketogenic Supplement Tricaprilin Fails in AD Trial

Are there any studies that show Ketosis preventing or slowing alzheimer's for us 4's? They all seem to work for non 4's but not us. Actually, there has yet to be a trial of ketogenic diets or supplements to show a clear positive effect in AD patients or people at high risk. And as you say, to the e...
by MichaelR
Mon May 07, 2018 8:52 pm
Forum: Science and Research
Topic: Ketogenic Supplement Tricaprilin Fails in AD Trial
Replies: 21
Views: 8529

Re: Ketogenic Supplement Tricaprilin Fails in AD Trial

I’m still struggling with why the amount of BHB matters if it’s the “storage” form, as long as you have some. Putting aside the fact that BHB is not technically a ketone at all: BHB is only a "storage" form of ketones (meaning, that it has to be converted to AcAc for use as fuel) in the p...
by MichaelR
Mon May 07, 2018 4:33 pm
Forum: Science and Research
Topic: Ketogenic Supplement Tricaprilin Fails in AD Trial
Replies: 21
Views: 8529

Ketogenic Supplement Tricaprilin Fails in AD Trial

All: Reporting from the Clinical Trials on Alzheimer's Disease 2017 conference : Samuel Henderson of Accera Inc. in Boulder, Colorado, explained negative results for tricaprilin [ie, caprylic triglyceride], Accera’s latest formulation of caprylic triglycerides to boost ketone body metabolism with a ...
by MichaelR
Fri Jun 24, 2016 5:52 pm
Forum: Our Stories
Topic: NMR results = total confusion!
Replies: 92
Views: 33799

Re: NMR results = total confusion!

Jumping in out of the blue just for a moment: Question: Does an increase in glycemic markers matter if they stay in a safe range? Is the fear that they'll keep rising and become problematic, or is the goal just to have them as low as possible? Thanks! The numerical differences on your latest tests a...
by MichaelR
Sun May 17, 2015 8:24 pm
Forum: Prevention and Treatment
Topic: Ketogenic Diets for AD Prevention: a "Large [and Unwise] Bet"
Replies: 56
Views: 25774

Re: Ketogenic Diets for AD Prevention: a "Large [and Unwise] Bet"

Oh, noooo .... Briefly : Michael, we shall hold our collective breath while you put together your unequivocal evidence refuting even the possibility that ketones could act as an alternative brain fuel: I've realized that there's actually a pretty good reason to think that whatever ketone bodies may ...