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by Brian4
Wed Apr 10, 2019 7:15 am
Forum: Science and Research
Topic: Fish oil and dementia: lack of (consistent) efficacy explained?
Replies: 3
Views: 213

Fish oil and dementia: lack of (consistent) efficacy explained?

Summary by ConsumerLab of new study: A study in Sweden among people with mild to moderate Alzheimer's disease found that daily supplementation with 1,700 mg of DHA and 600 mg of EPA for six months benefitted only those with adequate B vitamin status (determined by blood levels of homocysteine). In c...
by Brian4
Tue Apr 09, 2019 1:03 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 14
Views: 543

Re: Using RAPA for AD prevention

Hello Newtothis3/4, Some cautions about rapamycin: <> Dosing probably needs to be much, much higher to have a significant effect, so high that safety could be a concern: - 126 ppm rapamycin in chow (Bitto et al) is the human equivalent of 90 mg/day - 14 ppm (Harrison and others) is the human equival...
by Brian4
Sun Mar 31, 2019 2:04 am
Forum: Prevention and Treatment
Topic: Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease
Replies: 1
Views: 358

Re: Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease

Cool! Let's a hope full-blown study is done, one with isolation of the independent variables. “a low carbohydrate/high fat diet, also known as the ketogenic diet, calorie restriction (fasting), and both physical and cognitive exercises....” We really can't conclude anything about ketosis and dementi...
by Brian4
Sun Feb 10, 2019 7:16 am
Forum: Science and Research
Topic: Turning glial cells into neurons
Replies: 2
Views: 181

Turning glial cells into neurons

This is amazing work! Simple drug combination creates new neurons from neighboring cells February, 7, 2019 http://science.psu.edu/news-and-events/2019-news/Chen2-2019 "By using four molecules that modulate four critical signaling pathways in human astrocytes, we can efficiently turn human astro...
by Brian4
Fri Jan 11, 2019 6:46 am
Forum: Science and Research
Topic: How long after eating before authophagy starts?
Replies: 20
Views: 2612

Re: How long after eating before authophagy starts?

Important question Julie. I'm pretty sure it's mostly on/off. In other words, it's definitely not linear: 10% autophagy at 10% of the way towards the 2.5-day mark (for tissues where 2.5 days is the relevant figure...), 30% at 30% of the way... etc. But it doesn't suddenly go from zero to full-on aut...
by Brian4
Thu Jan 10, 2019 7:40 am
Forum: Science and Research
Topic: How long after eating before authophagy starts?
Replies: 20
Views: 2612

Re: How long after eating before authophagy starts?

We know very little about autophagy in humans.

I think significant autophagy will likely take at least two days to kick in in humans, and that's only in certain tissues. It may take even longer to kick in in the brain, since the brain is energy-privileged.

Brian
by Brian4
Tue Dec 18, 2018 4:30 pm
Forum: The Social Hour
Topic: Does anyone else use a rebounder?!
Replies: 26
Views: 2594

Re: Does anyone else use a rebounder?!

Hello Karina,

Could you explain what a "vibration machine" is? Professor Google thinks it's a vibration platform. Is that what you mean?

Thanks,
Brian
by Brian4
Sun Dec 02, 2018 2:02 am
Forum: The Social Hour
Topic: Genetic Engineering and unknown consequences
Replies: 44
Views: 3020

Re: Genetic Engineering and unknown consequences

Rainbow, I think I'll write a similar letter to myself, to be opened in 2040! As for the Harvard work, I think it's more of a demonstration for PR purposes than anything else. There's no reasonable scenerio under which babies born in the next few years or later will have to worry about ApoE4-induced...
by Brian4
Sat Dec 01, 2018 2:20 pm
Forum: The Social Hour
Topic: Genetic Engineering and unknown consequences
Replies: 44
Views: 3020

Re: Genetic Engineering and unknown consequences

J11, Someone should tell these people that some studies show epsilon-4 carriers are smarter than non-carriers (even in developed countries). "don\t ": I'm guessing you switch between different language keyboard layouts? I sometimes forget which one I'm using and write things like that. Brian
by Brian4
Fri Nov 30, 2018 1:13 am
Forum: The Social Hour
Topic: Genetic Engineering and unknown consequences
Replies: 44
Views: 3020

Re: Genetic Engineering and unknown consequences

Fiver, what I was really hoping for was the jetpacks. No luck. Damn it. J11, thanks. It doesn't surprise me that variants for higher intelligence would be associated with reduced risk of Alzheimer's (likely many other pathologies as well). Much of this could well be an indirect effect: smarter peopl...

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