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by Brian4
Sun Jun 02, 2019 2:31 am
Forum: Prevention and Treatment
Topic: Experiences with Low Dose Naltrexone
Replies: 39
Views: 2180

Re: Experiences with Low Dose Naltrexone

Julie! Wow, I must express the one pole of horror at your accident, and the other of joy about your success with LDN. (And by the way sorry for being so absent here at our forum. My job is full-bore.) My experience with LDN (at 4 mg now) is hard to assess. I started it mainly because of ME/CFS/SEID,...
by Brian4
Sun May 19, 2019 9:56 am
Forum: The Social Hour
Topic: Europeans?
Replies: 1
Views: 163

Re: Europeans?

Hello Csaebye, and welcome! There are plenty of Europeans here, and many Scandinavians. Most of the Scandinavians seem to be Swedes from around Stockholm, but at least one is in Lund, across the bridge from you if you per chance are in Copenhagen. So perhaps the basis of a get-together exists near y...
by Brian4
Tue Apr 23, 2019 9:47 am
Forum: Science and Research
Topic: Designing an E4 Fasting trial...
Replies: 30
Views: 2181

Re: Designing an E4 Fasting trial...

Fiver, great idea! Eager subjects, ready to follow protocols exactly, possessing lots of medical records – not easy for researchers to find.
by Brian4
Tue Apr 23, 2019 8:54 am
Forum: Science and Research
Topic: Designing an E4 Fasting trial...
Replies: 30
Views: 2181

Re: Designing an E4 Fasting trial...

We had spoken some time ago about encouraging Longo to do a fasting trial in humans, and, as I recall, his response was that he was more interested in doing mice studies. Looks like he's launching a trial with his diet and dementia. No info on whether he's stratifying for APOE status: https://www.be...
by Brian4
Wed Apr 10, 2019 7:15 am
Forum: Science and Research
Topic: Fish oil and dementia: lack of (consistent) efficacy explained?
Replies: 3
Views: 300

Fish oil and dementia: lack of (consistent) efficacy explained?

Summary by ConsumerLab of new study: A study in Sweden among people with mild to moderate Alzheimer's disease found that daily supplementation with 1,700 mg of DHA and 600 mg of EPA for six months benefitted only those with adequate B vitamin status (determined by blood levels of homocysteine). In c...
by Brian4
Tue Apr 09, 2019 1:03 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 14
Views: 742

Re: Using RAPA for AD prevention

Hello Newtothis3/4, Some cautions about rapamycin: <> Dosing probably needs to be much, much higher to have a significant effect, so high that safety could be a concern: - 126 ppm rapamycin in chow (Bitto et al) is the human equivalent of 90 mg/day - 14 ppm (Harrison and others) is the human equival...
by Brian4
Sun Mar 31, 2019 2:04 am
Forum: Prevention and Treatment
Topic: Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease
Replies: 1
Views: 416

Re: Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease

Cool! Let's a hope full-blown study is done, one with isolation of the independent variables. “a low carbohydrate/high fat diet, also known as the ketogenic diet, calorie restriction (fasting), and both physical and cognitive exercises....” We really can't conclude anything about ketosis and dementi...
by Brian4
Sun Feb 10, 2019 7:16 am
Forum: Science and Research
Topic: Turning glial cells into neurons
Replies: 2
Views: 224

Turning glial cells into neurons

This is amazing work! Simple drug combination creates new neurons from neighboring cells February, 7, 2019 http://science.psu.edu/news-and-events/2019-news/Chen2-2019 "By using four molecules that modulate four critical signaling pathways in human astrocytes, we can efficiently turn human astro...
by Brian4
Fri Jan 11, 2019 6:46 am
Forum: Science and Research
Topic: How long after eating before authophagy starts?
Replies: 20
Views: 2903

Re: How long after eating before authophagy starts?

Important question Julie. I'm pretty sure it's mostly on/off. In other words, it's definitely not linear: 10% autophagy at 10% of the way towards the 2.5-day mark (for tissues where 2.5 days is the relevant figure...), 30% at 30% of the way... etc. But it doesn't suddenly go from zero to full-on aut...
by Brian4
Thu Jan 10, 2019 7:40 am
Forum: Science and Research
Topic: How long after eating before authophagy starts?
Replies: 20
Views: 2903

Re: How long after eating before authophagy starts?

We know very little about autophagy in humans.

I think significant autophagy will likely take at least two days to kick in in humans, and that's only in certain tissues. It may take even longer to kick in in the brain, since the brain is energy-privileged.

Brian

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