Rapamycin mimics the effect of calorie restriction, so you can get the benefit with calorie restriction. Some well-done gene expression studies have shown that rapamycin and CR have partly overlapping effects but mostly have quite different effects. This was a big suprise! And a recent study sugges...

Thanks LondonGirl. I share your short list. (By the way, some 4/4s are making a variation of LX1001 available off-shore.)

Re BCG: Where can one get this?

https://ir.lexeotx.com/news-releases/news-release-details/lexeo-therapeutics-reports-fourth-quarter-and-full-year-2023 APOE4-associated Alzheimer’s Disease Programs: Lexeo completed enrollment of all four cohorts in the LEAD Phase 1/2 clinical trial of LX1001 for the treatment of APOE4-associated Al...

It's early days with this research, so I'm not sure of anything. But if homotaurine is a structure corrector, I'd want it to correct my apoE4 all the time. ApoE4 might help with brain development, but after childhood, I think its function is likely purely deleterious -- morning, noon, night. But who...

T, thanks. That's what I thought. I confess my kitchen is filled with blue stains, but I think I now know how to put the powder in capsules carefully. It seems like the easiest approach, for me at least. My next question is about getting non-contaminated MB. This was helpful: https://docs.google.com...

Aphorist. Good question. The Alzheon studies didn't look at different time of day dosing. I'm not sure it would make a huge difference, but, like you, I haven't yet fully digested the Nemergut paper. I'm aiming for the apoE4 structure corrector function, which makes me want to take homotaurine throu...

Quick question. Everyone seems to be speaking about taking MB as liquid drops. Is there some reason that is escaping me as to why one couldn't just put the right amount of powder into a capsule and pop the capsule? I have an accurate milligram scale, and lots of capsules.

Thanks,
Brian

Dr. Bredesen is very excited about this one and is partnering with a company to release a fairly inexpensive version soon.

Great news Julie -- thank you! I look forward to seeing this come to market.

Has anyone found a way to get a p-tau217 test?

Getting a doctor to sign up here --
https://alzpath.bio/
-- might work, but it's not clear that AlzPath has made the test available yet.

https://jamanetwork.com/journals/jamane ... le/2813751

N, thanks. Very helpful background info! I think I'll ignore my (slightly) suboptimal result.