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by rws
Tue Feb 25, 2020 1:56 am
Forum: Science and Research
Topic: Does having APOE4 protect you from getting the Coronavirus? .... Maybe
Replies: 27
Views: 3917

Re: Does having APOE4 protect you from getting the Coronavirus? .... Maybe

> people who catch the virus outside of China seem to be able to survive at a much higher rate I don't think the numbers support this. Also you need to exclude the effect that mild strains of the virus (if they exist) are preferably let through the controls. You can see this effect in many epidemics.
by rws
Mon Jan 13, 2020 2:47 am
Forum: Science and Research
Topic: In Medical News Today: What causes Alzheimer's? Not toxic amyloid, new study suggests
Replies: 4
Views: 700

Re: In Medical News Today: What causes Alzheimer's? Not toxic amyloid, new study suggests

It's all known for years, and was discussed here. Amyloid is an antimicrobial and part of the innate immune system. Researchers did not exclude this function so far from the pathologic process, but still only a few want to think further and test the brain infection hypothesis. It is a global self-sc...
by rws
Sat Sep 14, 2019 2:59 am
Forum: Science and Research
Topic: Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice
Replies: 1
Views: 321

Re: Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice

In case you are wondering: B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax Also Known As: APP/PS1 APP/PS1 are double transgenic mice expressing a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9), both directed to CNS neurons. Both mutations are associated...
by rws
Sat Feb 16, 2019 12:01 am
Forum: Science and Research
Topic: Food Allergy and Lectin ? affecting gut, opinons?
Replies: 2
Views: 663

Re: Food Allergy and Lectin ? affecting gut, opinons?

Following is a layman's opinion. I think the issue is broader than just lectins, but also more simple. Simple because any frequent high pressure in the gut with time probably increases inflammation. Broader because then any combination of gas-producing food plus immobile life style would increase th...
by rws
Thu Nov 15, 2018 9:38 pm
Forum: Science and Research
Topic: Nature/Science finally arrive at the brain microbiome
Replies: 0
Views: 695

Nature/Science finally arrive at the brain microbiome

Slowly the science establishment also gets the idea of a brain microbiome, through this conference paper: 594.08 / YY23 - The human brain microbiome; there are bacteria in our brains! https://abstractsonline.com/pp8/#!/4649/presentation/32057 Science: Do gut bacteria make a second home in our brains...
by rws
Wed Nov 14, 2018 9:29 pm
Forum: Science and Research
Topic: Question: Amyloid-beta vs beta-amyloid
Replies: 2
Views: 932

Re: Question: Amyloid-beta vs beta-amyloid

Am I correct in understanding that Amyloid-beta (Aß) is the peptide produced by our immune system and beta-amyloid is the plaque found in the brain which is associated with AD? The words define the same entity. However there are beta-amyloids of different length so the one produced for immune purpo...
by rws
Tue Oct 09, 2018 7:12 am
Forum: Science and Research
Topic: Periodontitis and sporadic Alzheimer's in mice
Replies: 3
Views: 1005

AD symptoms created in mice by feeding periodontitis bacteria

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. Ilievski V, Zuchowska PK, Green SJ, Toth PT, Ragozzino ME, Le K, et al. (2018) PLoS ONE 13(10): e0204941. https://doi.org/10.1371/journal.pone.0204941 &q...
by rws
Thu Sep 06, 2018 12:23 am
Forum: Science and Research
Topic: A new paper finds interesting correlations between intestinal permeability and other health conditions
Replies: 1
Views: 645

Re: A new paper finds interesting correlations between intestinal permeability and other health conditions

Very good (or bad). I think a next step in the research would be to determine which agent is responsible that passes through the IB: is it extracellular vesicles (from gut bacteria), or is it (living or dead) bacterial cells, that cause sufficient, and permanent inflammation of neural tissue. Which ...
by rws
Wed Jul 04, 2018 9:22 pm
Forum: Science and Research
Topic: Dark Side of 23&Me and Prometheus
Replies: 15
Views: 3696

Re: Dark Side of 23&Me and Prometheus

Could the NYT not have been more detailed? I mean it's not exactly rocket science what 23aNdme is doing. Mutation screening (at many positions at the same time) is done using microarrays, and if there is an error rate the manufacturer of the microarrays is to blame. Poor investigation, maybe intenti...
by rws
Sat Jun 23, 2018 10:04 am
Forum: Science and Research
Topic: virus linked to Amyloid Beta
Replies: 4
Views: 1130

Re: virus linked to Amyloid Beta

See previous thread.

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