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by xactly
Wed Mar 04, 2020 8:08 am
Forum: Prevention and Treatment
Topic: Is anyone taking Metformin for longevity (or considering it)?
Replies: 19
Views: 1517

Re: Is anyone taking Metformin for longevity (or considering it)?

Valisure just released the following: "Valisure has tested and detected high levels of the probable human carcinogen N-Nitrosodimethylamine (NDMA) in specific lots of the drug metformin, a prescription medication used to control high blood sugar in adults and adolescents with type 2 diabetes. I...
by xactly
Sun Feb 09, 2020 9:08 am
Forum: Prevention and Treatment
Topic: Exercise and Ketosis
Replies: 4
Views: 394

Re: Exercise and Ketosis

Possibly this is even where some of the benefit of exercise comes from, though I think most people DO eat before exercise, fearing low energy if they don't. Does this all seem unexpected... or obvious lol? Rhonda Patrick (Found My Fitness) has shared research that says you only burn fat when you ex...
by xactly
Wed Feb 05, 2020 4:27 pm
Forum: Prevention and Treatment
Topic: Finding the cure for dementia | 60 Minutes Australia (YouTube Video)
Replies: 2
Views: 248

Re: Finding the cure for dementia | 60 Minutes Australia (YouTube Video)

Very interesting --- well, the last ten minutes or so were most interesting to me. Concluding that may be tiny strokes that cause dementia, etc. Also info on blood pressure and impact. https://youtu.be/iEpTH70xRIs That was interesting. My understanding has been that vascular dementia (the micro-inf...
by xactly
Wed Jan 29, 2020 6:45 am
Forum: Prevention and Treatment
Topic: Can Herpes Zoster ophthalmicus (Shingles) affect the Alzheimer's brain?
Replies: 17
Views: 1129

Re: Can Herpes Zoster ophthalmicus (Shingles) affect the Alzheimer's brain?

Does anybody know if Herpes Zoster ophthalmicus (or Shingles on and above the eye) affects the brain of Alzheimer's patients in a different way than normally? Britta This is anecdotal (n=2), but my mother and my mother-in-law (both APOE4 carriers) presented symptoms of dementia within days or weeks...
by xactly
Tue Jan 21, 2020 12:13 pm
Forum: Prevention and Treatment
Topic: When to take the supplements?
Replies: 1
Views: 200

Re: When to take the supplements?

I have not been able to find in Bredesen's book a recipe of when to take each supplement (maybe there is, but I have not found it). Of course, melatonin is before sleeping. But what about the other pills? B12 / folate / D3 & K2 / ...? Does it matter when to take them? All at the same time? Sepa...
by xactly
Sun Jan 05, 2020 10:17 am
Forum: Science and Research
Topic: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Replies: 5
Views: 652

Re: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

I did find this article Training Center: Why heart rate shouldn't be ignored which suggests that, once you've developed a lactate utilization profile and correlated it with heart rates, you can use heart rate as a proxy to define your zone. And you might also be able to use disciplined time trial t...
by xactly
Sat Jan 04, 2020 8:09 am
Forum: Science and Research
Topic: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Replies: 5
Views: 652

Re: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

I'm going to modify my own exercise regimen around this Zone 2 conditioning framework. The explanations of how lactate works in the body (and its role in cancer) were superb. The discussion really connected a lot of metabolic pathways and concepts for me. I would also like to modify my exercise reg...
by xactly
Sat Dec 28, 2019 7:14 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 90
Views: 11223

Re: Zero carb diet will help prevent Alzheimer’s

In our upcoming book, Dr. Bredesen adds an Omega-3 index goal of greater than 10% for E4 carriers. If you decide to experiment with using only plant sources (which feels a bit risky to me, but may work given your favorable genetics) you are in a perfect position to inform us all. Here's a link for ...
by xactly
Fri Dec 27, 2019 9:48 am
Forum: Science and Research
Topic: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Replies: 5
Views: 652

Re: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

I also am finding this episode fascinating. I'm about halfway through. I am particularly interested in the statement that lactate is an important fuel source for the body and brain. It is not, as is popularly thought, a waste product. San Millan states that lactate is actually a better fuel for the ...
by xactly
Mon Dec 23, 2019 2:52 pm
Forum: Prevention and Treatment
Topic: Zero carb diet will help prevent Alzheimer’s
Replies: 90
Views: 11223

Re: Zero carb diet will help prevent Alzheimer’s

A worry I have is that the effect: "It [natural selection] couldn't care less about genes and lifestyle choices that keep you physically and mentally healthy into old age" validly made by xactly might be worse than "couldn't care". It might be "antagonistic pleiotropy"...

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