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by Searcher
Wed Sep 26, 2018 5:10 am
Forum: Getting Started
Topic: What is the absolute risk?
Replies: 13
Views: 3753

Re: What is the absolute risk?

I have been unable to figure out or locate any info on the absolute risk. Anyone have info on this? This presentation seems relevant (look at P1-381). https://www.alzheimersanddementia.com/article/S1552-5260(16)31435-2/abstract 9703 subjects followed prospectively. Each characterized by genotype in...
by Searcher
Fri Jul 13, 2018 7:59 am
Forum: Science and Research
Topic: New paper suggests that ketosis may be helpful for ApoE4 carriers
Replies: 12
Views: 1853

Re: New paper suggests that ketosis may be helpful for ApoE4 carriers

Fiver,

Just tying this abstract in with existing knowledge to draw practical implications.

More background info here:

https://www.physiology.org/doi/10.1152/advan.00052.2006
by Searcher
Fri Jul 13, 2018 5:13 am
Forum: Science and Research
Topic: New paper suggests that ketosis may be helpful for ApoE4 carriers
Replies: 12
Views: 1853

Re: New paper suggests that ketosis may be helpful for ApoE4 carriers

The abstract states: "PGC-1α overexpression ameliorated ApoE4-induced deficits in glycolysis and mitochondrial respiration." This is useful to know, because PGC-1α expression can be influenced by what we do. Cold exposure, fasting and exercise all tend to increase PGC-1α expression. They m...
by Searcher
Thu Jun 21, 2018 3:14 am
Forum: Our Stories
Topic: Sleep!
Replies: 58
Views: 9782

Re: Sleep!

Four in the AM three in the PM. I decided to try the multi vitamin that I heard about on this site called ONE. It was the only change I made and wallah!! I have been taking it in the AM and I am waking up only once at night b3M, The fluids taken along with the vitamins in the pm might be sufficient...
by Searcher
Wed Jun 20, 2018 4:23 am
Forum: Our Stories
Topic: Help! I'm going under
Replies: 52
Views: 5970

Re: Help! I'm going under

The one thing missing, or feeble, in most protocols for preventing Alzheimer's, is emotional well-being. Yet, according to the panel of experts who authored the Lancet article on dementia in 2017, the highest increase in risk for dementia comes from depression. They may or may not be completely accu...
by Searcher
Tue May 22, 2018 3:03 am
Forum: Our Stories
Topic: Long Term Care Insurance
Replies: 8
Views: 1055

Re: Long Term Care Insurance

Setting up a financial cushion for long-term care makes sense in many ways. We do everything possible to avert cardiovascular disease, Alzheimer's and other conditions. Much is within our control, but not everything. For most people, building a financial cushion will involve setting aside some money...
by Searcher
Sat May 05, 2018 4:45 am
Forum: Our Stories
Topic: Trying the protocol in advanced alzheimers
Replies: 17
Views: 2429

Re: Trying the protocol in advanced alzheimers

chrystina3 wrote:I am so thankful that I get to do this.


That is simply beautiful and touching, Chrystina.
by Searcher
Tue May 01, 2018 2:15 pm
Forum: Our Stories
Topic: Lost in the rabbit hole -- want a reality check.
Replies: 15
Views: 1911

Re: Lost in the rabbit hole -- want a reality check.

Martha, It's normal to feel how you do from time to time. But it's not helpful to pretend that the purpose of life is to avoid Alzheimer's or CVD. Those are worthy aims, but they don't bring the joy and fulfilment that most of us crave. Paradoxically, stressing about getting every last detail of a p...
by Searcher
Fri Apr 27, 2018 9:59 am
Forum: Prevention and Treatment
Topic: Social support & the reverse
Replies: 4
Views: 701

Social support & the reverse

"A recent study among 5,475 men and 4,580 women aged over 50 showed that a single point increase in negative social support score resulted in a 31 percent rise in the risk of eventual dementia. Negative social support is where you experience a lot of critical, unreliable and annoying behaviors ...

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