Search found 620 matches

by Plumster
Wed Mar 27, 2024 7:19 am
Forum: Our Stories
Topic: 24 and 4/4
Replies: 6
Views: 100

Re: 24 and 4/4

Hi all, I’m really really sad to be joining this forum. I found out today that I’m 4/4 for APOE4 and have no idea where to start. I’m 24, just graduated college, I have no family history of dementia or AZ (I did lose my grandfather in his late 60s to a heart attack though, so there’s some cardiac b...
by Plumster
Mon Mar 25, 2024 6:19 am
Forum: Science and Research
Topic: Rapamycin prevents age-related brain vascular deterioration in rats
Replies: 27
Views: 9949

Re: Rapamycin prevents age-related brain vascular deterioration in rats

hi -I am having my first appointment with Dr Green next month. I am 54, 4/4 and found out a couple of years ago through 23& me, but sort of ignored it at first, then got really frightened... Then I decided to do something about it and am studying biomedicine... Also started weight training and ...
by Plumster
Mon Mar 11, 2024 8:30 am
Forum: Prevention and Treatment
Topic: APOE 4/4 - Wisdom on telling siblings/children
Replies: 7
Views: 1066

Re: APOE 4/4 - Wisdom on telling siblings/children

Thank you for your thoughtful post, Maria. I love your statement that "we are the CEOs of our health". For the first 10 or so years I knew about being 4/4 AD just seemed like a mysterious boogeyman that may be hiding in your closet. it he's there, he'll jump out someday and steal your bra...
by Plumster
Fri Mar 08, 2024 6:32 am
Forum: Getting Started
Topic: ApoE4 and life expectancy/longevity
Replies: 12
Views: 4774

Re: ApoE4 and life expectancy/longevity

I was just watching this video/transcript from Nutritionfacts that came out two days ago: APOE—The Single Most Important Gene for Longevity" in which Dr. Greger suggests that high cholesterol levels in Apoe4 may be the main cause for less longevity. He proposes that e4s lower LDL by lowering sa...
by Plumster
Wed Feb 28, 2024 1:35 pm
Forum: Prevention and Treatment
Topic: Statins and Dementia studies
Replies: 19
Views: 16266

Re: Statins and Dementia studies

I used to monitor my LDL and apoB, but I don't know anymore if it is relevant. Hi again Maria4/4, here is a reason to monitor LDL and ApoB: Mendelian randomization reveals apolipoprotein B shortens healthspan and possibly increases risk for Alzheimer’s disease Leah Martin, Brian B. Boutwell, Carmen...
by Plumster
Tue Feb 20, 2024 8:57 am
Forum: Prevention and Treatment
Topic: Statins and Dementia studies
Replies: 19
Views: 16266

Re: Statins and Dementia studies

An LDL of approximately 70 is great, but not particularly low -- except maybe for an e4.

LDL and apoB are the measurements to pay attention to. Optimal apoB is 40-80, ideally below 62.

I would like to discourage you from attempting to raise either LDL or apoB.
by Plumster
Mon Feb 19, 2024 11:30 am
Forum: Prevention and Treatment
Topic: Statins and Dementia studies
Replies: 19
Views: 16266

Re: Statins and Dementia studies

Hi Maria4/4, Thanks for adding this information to the discussion and for providing the link. Have you tried any of these alternatives yourself? Hi Floramaria, I didn’t try them because my cholesterol levels are low. Perhaps even too low 😒 Too low? Care to elaborate? I assume you are not saying tha...
by Plumster
Sat Jan 27, 2024 6:51 am
Forum: Our Stories
Topic: Pregnant , age 44 & 4/4
Replies: 2
Views: 535

Re: Pregnant , age 44 & 4/4

Hi there - so we have a surprise pregnancy (but very much wanted). I am 43 but 44 in 2 weeks. I found out about my 4/4 status approx 4 years ago. I fast most days and take the recommended supplements etc. But i have been lax with my diet. My questions are , will this pregnancy ‘accelerate’ any issu...
by Plumster
Fri Jan 26, 2024 6:44 am
Forum: Getting Started
Topic: Panicking 41yr old grown up man
Replies: 15
Views: 16135

Re: Panicking 41yr old grown up man

This diet is totally the opposit what I should eat according what I found in this forum :( I bearly eat fat There is not just one recommended diet for AD prevention. I am also low fat plant based and it works for me, as evidenced by my A1c, Apob/LDL, and how I feel. Others do a Mediterranean diet o...
by Plumster
Sat Jan 06, 2024 5:48 am
Forum: Prevention and Treatment
Topic: Anyone taking GlyNac?
Replies: 0
Views: 4690

Anyone taking GlyNac?

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial Premranjan K...