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by karelena
Tue Aug 04, 2020 2:10 am
Forum: Our Stories
Topic: MTHFR C677T and E4/E4
Replies: 4
Views: 517

Re: MTHFR C677T and E4/E4

Thank you SusanJ for the methylation wiki page! I think reducing homocysteine is important and I wonder if unknown high homocysteine was a factor in many heart attacks on my dad's side of the family.
by karelena
Mon Aug 03, 2020 1:00 am
Forum: Our Stories
Topic: MTHFR C677T and E4/E4
Replies: 4
Views: 517

Re: MTHFR C677T and E4/E4

For C677T MTHFR deficiency, I take methylfolate and methylcobalamin. The supplement I use is Life Extension "Homocysteine Resist," but there are many options. This brought my homocysteine level down from 12 to 7. Do you know what your homocysteine level is? I believe there is a section on ...
by karelena
Thu Jul 23, 2020 6:56 pm
Forum: Science and Research
Topic: study: Tb vaccine lowers AD risk.
Replies: 26
Views: 3747

Re: study: Tb vaccine lowers AD risk.

I just read this about BCG and covid. I knew it was being studied. This paper uses results of covid 19 mortality rates only up until April 22. I think the death rate is rising in countries with universal BCG vaccinations in more recent months :( https://www.pnas.org/content/early/2020/07/07/2008410117
by karelena
Wed Jul 15, 2020 1:15 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 7266

Re: Using RAPA for AD prevention

I am taking Fisetin every 4-5 weeks for 2 days in a row, 1500 mg. This is the protocol for the human trial Mayo used. Dr. Green did his own calculations and came out with the same conclusion. Are there any results from the Mayo Clinic human trial? All I can find is results of one of their dasatinib...
by karelena
Sat Jul 11, 2020 2:48 am
Forum: Science and Research
Topic: study: Tb vaccine lowers AD risk.
Replies: 26
Views: 3747

Re: study: Tb vaccine lowers AD risk.

There are a lot of articles about the adjuvant MPLA and Alzheimer's. Here's one:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562771/
by karelena
Sat Jul 11, 2020 2:19 am
Forum: Science and Research
Topic: study: Tb vaccine lowers AD risk.
Replies: 26
Views: 3747

Re: study: Tb vaccine lowers AD risk.

Research has found that MPLA is a powerful anti-dementing agent. A family member was able to receive a dose by being vaccinated with Cervarix. I think a hay fever vaccine also uses MPLA. The new Shingrix vaccine for adults over 50 who have had chicken pox also has MPLA according to the CDC. The old...
by karelena
Fri Jul 10, 2020 6:11 pm
Forum: Science and Research
Topic: study: Tb vaccine lowers AD risk.
Replies: 26
Views: 3747

Re: study: Tb vaccine lowers AD risk.

Those are both very imaginative answers. Sometimes it is not so much the right answer that is as interesting as other possible responses. I was going to give the hint The City of Angels in my last post thought that would have given away the answer right away. Is the answer membrane plasmalogens? Bu...
by karelena
Fri Jul 10, 2020 6:00 pm
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 7266

Re: Using RAPA for AD prevention

But note that even with the factor of 12 scaling, the dose would still be vastly higher than what Green and others are recommending. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996648/ Even with 12:1 scaling, that's a massive dose. Brian I have read some newer articles with "low dose rapamyc...
by karelena
Fri Jul 10, 2020 3:53 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 7266

Re: Using RAPA for AD prevention

I I decided not to take rapamycin, partly for reasons cited earlier (dosage needed for effect is probably huge), but mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR...
by karelena
Thu Jul 09, 2020 4:44 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 7266

Re: Using RAPA for AD prevention

I am confident that anyone who takes Rapamycin intermittently before AD symptoms appear will never get AD (or cancer, diabetes, etc). I am not so confident that it will 100% prevent AD, but I started taking it too a couple of weeks ago. It just seems that the mechanism of action would be helpful in...

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