Search found 81 matches

by karelena
Sun Mar 26, 2023 3:52 am
Forum: Prevention and Treatment
Topic: Lecanamab: Efficacy, Side Effects, and More
Replies: 58
Views: 17663

Re: Lecanamab: Efficacy, Side Effects, and More

Thank you NF52 for your reply. Those are some scary charts for E44s, 80% amyloid positivity at age 65. So much higher than the other groups. Do you happen to know the conversion formula from SUVR to centiloids? Also, I was asking about the amyloid blood test, The AB42/40 ratio in blood (plasma). For...
by karelena
Sat Mar 25, 2023 1:33 am
Forum: Prevention and Treatment
Topic: Lecanamab: Efficacy, Side Effects, and More
Replies: 58
Views: 17663

Re: Lecanamab: Efficacy, Side Effects, and More

When I was being evaluated for the study they said I qualified to have a brain amyloid PET scan based on my amyloid blood test (amyloid 42/40 ratio). My PET scan result was < 20 centiloids so I did not qualify to proceed further in the study, as I mentioned in an earlier post. But I was worried abou...
by karelena
Mon Jan 23, 2023 3:34 am
Forum: Prevention and Treatment
Topic: Celebration Thread! Biogen is going to the FDA with Aducan.
Replies: 1808
Views: 347467

Re: Celebration Thread! Biogen is going to the FDA with Aducan.

I would think that the pre-MCI microdosing that I am suggesting would decrease on label risk by an order of magnitude. It already does not seem to demonstrate sound clinical judgment to wait and wait and then treat with the maximal clinically tolerated dose. I hope there is efficacy with pre-MCI tr...
by karelena
Mon Jan 23, 2023 2:44 am
Forum: Prevention and Treatment
Topic: Lecanamab: Efficacy, Side Effects, and More
Replies: 58
Views: 17663

Re: Lecanamab: Efficacy, Side Effects, and More

The graph from TeresaB's post on page 4 of this thread:
by karelena
Sat Jan 21, 2023 8:01 pm
Forum: Prevention and Treatment
Topic: Lecanamab: Efficacy, Side Effects, and More
Replies: 58
Views: 17663

Re: Lecanamab: Efficacy, Side Effects, and More

There’s an alternative with BETTER results, benign side-effects, and no deaths vs the 3 deaths that have been alleged to leqembi. Screenshot 2023-01-21 153935.jpg I don't think we can directly compare the data from the article cited in the bar graph above (by Toups etal) with the lecanemab study. F...
by karelena
Tue Dec 27, 2022 4:45 pm
Forum: Prevention and Treatment
Topic: Lecanamab: Efficacy, Side Effects, and More
Replies: 58
Views: 17663

Re: Lecanamab: Efficacy, Side Effects, and More

Hi, I did ask about the MRI sequences used in the study and the study coordinator did not know the exact sequences, he just said he was sure they would be the most sensitive to detect hemorrhages, so the question of whether MP-RAGE is being used is still unanswered. NF52 is working on an answer to t...
by karelena
Mon Dec 12, 2022 1:46 am
Forum: Prevention and Treatment
Topic: Lecanamab: Efficacy, Side Effects, and More
Replies: 58
Views: 17663

Re: Lecanamab: Efficacy, Side Effects, and More

Julie, I hope your mother is recovering well. I know she is fortunate to have you as her advocate. I have been reading the posts on this thread, and the ones about brain volume loss with lecanemab. I am not entirely convinced that the volume loss is not due to loss of amyloid. I don't think they can...
by karelena
Thu Dec 01, 2022 3:51 pm
Forum: Prevention and Treatment
Topic: CTAD 2022 -- Endgame for AD
Replies: 58
Views: 3651

Re: CTAD 2022 -- Endgame for AD

Dis they compare the outcome of the E 4/4 with lecanemab to the E 4/4s on placebo? Or are they only compared to the placebo group as a whole?
by karelena
Thu Dec 01, 2022 3:49 pm
Forum: Prevention and Treatment
Topic: CTAD 2022 -- Endgame for AD
Replies: 58
Views: 3651

Re: CTAD 2022 -- Endgame for AD

I wish there were mora data on the E 4/4s to try to explain the unexpected finding that they did worse than placebo. Were they more MCI and less early AD? What about age/sex/race/national origin? I also think the result is surprising.
by karelena
Tue Nov 29, 2022 3:45 am
Forum: Prevention and Treatment
Topic: Lecanamab: Efficacy, Side Effects, and More
Replies: 58
Views: 17663

Re: Lecanamab: Efficacy, Side Effects, and More

It is not clear whether the patient had ARIA. From what I read it was a stroke. When TPA is used after a stroke, it is only for non-hemorrhagic strokes and a CT or MRI is required before giving TPA, to exclude any hemorrhage because that would be a contraindication to TPA. So it would have been an i...