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by alangreenmd
Wed Feb 07, 2018 11:42 am
Forum: Prevention and Treatment
Topic: HBA1c, what is ideal
Replies: 46
Views: 10387

Re: HBA1c, what is ideal

Hi Julia,
Thanks for directing my attention to "thread".
I agree with you 100%; he would not agree with me.
I am basically a mouse person; but also like autopsy studies of human brain.
I don't like theories, unless theory comes from somebody born in St. Petersburg, Russia.
by alangreenmd
Wed Feb 07, 2018 10:57 am
Forum: Prevention and Treatment
Topic: HBA1c, what is ideal
Replies: 46
Views: 10387

Re: HBA1c, what is ideal

Hi Julia, The 2016 summary paper by Lin, in which quote portion of first paragraph shows why worth the effort: "APOE4 carriers accumulate beta-amyloid and neurofibrillary tau tangles earlier and with more extensive pathology compared to non-carriers, However, decades before the aggregation of A...
by alangreenmd
Wed Feb 07, 2018 10:19 am
Forum: Prevention and Treatment
Topic: HBA1c, what is ideal
Replies: 46
Views: 10387

Re: HBA1c, what is ideal

Hi OrangeBlossom, Thanks for asking great question. Yesterday Julia posted paper by Robert Mahley. In the last 10 pages Robert Mahley presents his his own theory, none of which I happened to agreed with; but on page 4, while still in introduction mode he answers your question. The following is quote...
by alangreenmd
Wed Feb 07, 2018 7:59 am
Forum: Prevention and Treatment
Topic: HBA1c, what is ideal
Replies: 46
Views: 10387

Re: HBA1c, what is ideal

Hi Stavia, Thanks so much for quick response and posting a paper and identify specific section to read. That was excellent as shows the reason for wrong analysis. They calculate glucose uptake and conclude glucose under utilization reflects a primary problem in glucose as opposed to primary problem ...
by alangreenmd
Tue Feb 06, 2018 10:22 pm
Forum: Prevention and Treatment
Topic: HBA1c, what is ideal
Replies: 46
Views: 10387

Re: HBA1c, what is ideal

Hi Stavia, Here are the 4 studies I quote by Reiman 2001, Reiman 2005, Thambisetty, 2010, Reiman 2004. These are all open access. All one has to do is read the studies. It is 100% clear they are measuring cerebral blood flow not insulin resistance. I will quote the section which is very brief summar...
by alangreenmd
Tue Feb 06, 2018 8:18 pm
Forum: Prevention and Treatment
Topic: HBA1c, what is ideal
Replies: 46
Views: 10387

Re: HBA1c, what is ideal

Hi I would describe the above interpretation of Rand Akasheh as TOTALLY WRONG. This is extremely important. The fundamental defect in APOE4 carriers which begins in the 20-39 year age group is decreased blood flow in same areas which later develop changes of AD. These defects in cerebral blood flow ...
by alangreenmd
Tue Feb 06, 2018 7:26 pm
Forum: Prevention and Treatment
Topic: MIND diet
Replies: 16
Views: 4509

Re: MIND diet

Thanks Julie,
They said control group had regular chow and other group had "canola oil-enriched diet (50 mg/Kg, CO)". They used Mazola canola oil.
To me, standard mouse chow is pretty bland; but mix in some canola oil and it's like Dunkin donuts.
by alangreenmd
Tue Feb 06, 2018 6:59 pm
Forum: Science and Research
Topic: link to research article
Replies: 4
Views: 1454

Re: link to research article

That looks like very promising treatment for 2% who have genetic early onset AD.
by alangreenmd
Tue Feb 06, 2018 6:54 pm
Forum: Science and Research
Topic: Htr-A1 - ApoE4 degrading enzyme
Replies: 21
Views: 6064

Re: Htr-A1 - ApoE4 degrading enzyme

AD is like a Jig saw puzzle with 250 pieces; the hard part is you have 1000 pieces in the box. In you look at the research of Berislav Zlokovic, Salvatore Oddo, Patricia Galvan, Ai-Ling Lin, JJ Pei; it all fits together into one very coherent picture, all supported by autopsy finding in human brain ...
by alangreenmd
Tue Feb 06, 2018 2:58 pm
Forum: Science and Research
Topic: Htr-A1 - ApoE4 degrading enzyme
Replies: 21
Views: 6064

Re: Htr-A1 - ApoE4 degrading enzyme

On Tau pathology. AD especially in APOE4 carriers is a 2 hit disease. There is what APOE4 does in hit 1, degeneration of cerebral microvascular system and breakdown of BBB. Then there is 2nd hit: amyloid-beta and hyperphosphorylated Tau All totally different steps and all very interrelated For best ...

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