There are research groups studying the drug rapamycin for potential efficacy in "life extension". If I had to guess, this particular anti-rejection drug could be the one referred to in the first post.

Took a look at the article Published: 29 April 2020 APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline Axel Montagne, Daniel A. Nation, […]Berislav V. Zlokovic Nature volume 581, pages71–76(2020) There is no mention that I can find regarding these small molecules. I will che...

Yes. I'll copy the text over to here so folks can have a look. A new paper in the journal Neurology looks at the multi-year effects of dietary flavonols on Alzheimer's. http://dx.doi.org/10.1212/WNL.0000000000008981 In this study, 921 participants with no initial dementia were followed over several ...

I have been taking 150 mg of NR (Niagen) for about one year. No changes in my bloodwork. Upped the dose to 300 mg, then 900 mg about one month ago. I did not notice any changes in how I feel or sleep with the dosage increase. Have not had bloodwork on the higher dose yet. Found NMN on Alibaba (China...

A new paper in the journal Neurology looks at the multi-year effects of dietary flavonols on Alzheimer's. http://dx.doi.org/10.1212/WNL.0000000000008981 In this study, 921 participants with no initial dementia were followed over several years, with 220 of those persons ultimately developing dementia...

Here is an article reviewing Alzheimer's research throughout 2019. It is a long, very interesting read covering a wide diversity of AD research topics and ideas that show some promise.

https://www.alzforum.org/news/research- ... s-research

Here is one with a 2021 time frame

https://www.nia.nih.gov/alzheimers/clin ... ve-decline

With the top risk factor for AD being age, longevity research, or research on how to simply live longer, seems very interesting to me. Here is an article on lifestyle factors affecting longevity in "blue zones", where people may live to over 100 years and do not develop dementia at a high ...

I have been using 150 mg NR since shortly after it became commercially available (as Niagen). There have been no noticeable changes to any of my cholesterol levels, nor have I noticed any other side effects (good or bad). There is a newer podcast from Dr. Sinclair on aging and the correlation betwee...

Here is a link to a thread on the blood brain barrier and its association with AD.

viewtopic.php?f=16&t=5721&p=64129&hilit=blood+brain+barrier#p64129