Looks like this is an open access paper at Nature.
https://www.nature.com/articles/s41586-024-07185-7
Search found 56 matches
- Thu Mar 21, 2024 3:48 pm
- Forum: Science and Research
- Topic: Root cause of Alzheimer's may be fat buildup in brain cells, especially in ApoE4s?
- Replies: 2
- Views: 218
- Mon Feb 05, 2024 4:39 pm
- Forum: Prevention and Treatment
- Topic: NAD
- Replies: 3
- Views: 472
- Thu Dec 14, 2023 10:59 am
- Forum: Prevention and Treatment
- Topic: Increasing BDNF
- Replies: 1
- Views: 9710
Increasing BDNF
Many research groups familiar to folks on this site have mentioned brain derived neurotropic factor (BDNF) as a very important factor in overall brain health, especially as we age. Here is a free PDF from Dr. Rhonda Patrick that helps describe a number of ways we can increase our levels of BDNF. The...
- Sun Oct 22, 2023 3:45 pm
- Forum: Prevention and Treatment
- Topic: I Can Hardly” Believe It Viagra Reduces Alz Risk
- Replies: 25
- Views: 6001
Re: I Can Hardly” Believe It Viagra Reduces Alz Risk
From a research group at Mt Sinai using a large data-based analysis of over 50k individuals: "The propensity score stratified univariate analysis and the Cox regression model showed that sildenafil use was significantly associated with a 60% risk reduction of developing Alzheimer's disease (HR=...
- Tue Sep 05, 2023 5:50 pm
- Forum: Science and Research
- Topic: Homotaurine (tramiprosate) appears to be a structure corrector
- Replies: 77
- Views: 131270
Re: Homotaurine (tramiprosate) appears to be a structure corrector
Is anyone aware of a comparison of homotaurine with the garden variety taurine? There are many, many articles published in the scientific literature on the benefits of taurine for the brain. Taurine Sci Rep.pdf Taurine Nature.pdf Plain old taurine may also show some benefits for longevity (many arti...
- Thu Jan 26, 2023 9:16 am
- Forum: Prevention and Treatment
- Topic: ACI-24.060
- Replies: 0
- Views: 420
ACI-24.060
Interesting phase1/2 result. AC Immune's "vaccine" ACI-24.060 has showed positive results and initial safety at low doses. The trial is now moving to higher doses. The drug is a liposome vaccine that stimulates one's own body to produce amyloid beta antibodies and subsequently clear the pl...
- Fri Apr 01, 2022 4:07 pm
- Forum: Science and Research
- Topic: ALZ-801, tramiprosate, Ptau-181
- Replies: 11
- Views: 1882
Re: ALZ-801, tramiprosate, Ptau-181
Thanks all. I will also continue my 2 per week 100 mg of homotaurine.
- Thu Mar 31, 2022 1:51 pm
- Forum: Science and Research
- Topic: ALZ-801, tramiprosate, Ptau-181
- Replies: 11
- Views: 1882
Re: ALZ-801, tramiprosate, Ptau-181
Thanks all for these updates. I believe that tramiprosate is simply homotaurine (is this correct?) Homotaurine is the amino acid taurine with an additional carbon atom attached. You can purchase it inexpensively on the web: https://us.supersmart.com/en/shop/brain-nutrition/homotaurine-supplement-066...
- Sun Feb 20, 2022 10:26 am
- Forum: Prevention and Treatment
- Topic: You CAN Turn Back Time
- Replies: 5
- Views: 1943
Re: You CAN Turn Back Time
For those interested in "life extension" overall, as well as its relationship to cognitive decline, here are a few recent podcasts from David Sinclair at Harvard Medical School: https://www.youtube.com/watch?v=X1kLizzdb2c https://www.youtube.com/watch?v=wD8reCw3Kls https://www.youtube.com/...
- Fri Dec 10, 2021 8:35 am
- Forum: Science and Research
- Topic: Microglial correlates of late life physical activity
- Replies: 2
- Views: 690
Re: Microglial correlates of late life physical activity
Here is an interesting article from Harvard Medicine on "Inflammation and Brain Health" that correlates to this discussion on using exercise to reduce brain inflammation.
https://hms.harvard.edu/magazine/aging/ ... ain-health
https://hms.harvard.edu/magazine/aging/ ... ain-health