Our 3rd annual meet-up will piggyback on the LowCarb USA conference in San Diego, CA, August 3-6.

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by Harrison
Fri Jun 23, 2017 12:44 pm
Forum: Our Stories
Topic: New 4/4 Have Question About Siblings
Replies: 10
Views: 206

Re: New 4/4 Have Question About Siblings

Hi AKDeb, As ru442 has pointed you in the direction of the primer, I'll specifically tackle your probability question. Unfortunately, there is no way to answer this without more information. If you know both of your parents' genotypes, you can calculate the probability. If not, since you are E4/4, e...
by Harrison
Fri Jun 23, 2017 8:55 am
Forum: Science and Research
Topic: High-fat diet leads to same intestinal inflammation as a virus
Replies: 10
Views: 235

Re: High-fat diet leads to same intestinal inflammation as a virus

From mice to men? From Harrison: Rodent diet studies are limited in their generalizability. A slightly different way of thinking about this is that in mice, fat appears to be necessary to create a pro-inflammatory environment. In humans, sucrose appears to be necessary for a pro-inflammatory enviro...
by Harrison
Wed Jun 21, 2017 10:31 am
Forum: Our Stories
Topic: Weight gain problems.... Any advice very welcome...
Replies: 15
Views: 328

Re: Weight gain problems.... Any advice very welcome...

Hi Gemma, I have a friend who is your exact height and weight. She often felt tired, but had difficulty sleeping, so she started adding collagen to tea. This has made a world of difference. See this thread for some comments from other members about collagen: https://www.apoe4.info/forums/viewtopic.p...
by Harrison
Wed Jun 14, 2017 1:12 pm
Forum: Our Stories
Topic: Apoe4 and diet
Replies: 3
Views: 196

Re: Apoe4 and diet

My comment is that rodents don't do well on fat, while humans can (if not coupled with excessive sugar). So may not be a good model. This is a very good point, and why rodent diet studies are limited in their generalizability. A slightly different way of thinking about this is that in mice, fat app...
by Harrison
Mon Jun 12, 2017 2:29 pm
Forum: Prevention and Treatment
Topic: How Not to Die
Replies: 17
Views: 1091

Re: How Not to Die

Here's a table I cobbled together between AD cases per 100000 people and ApoE4 allele rates (% of population with at least 1 allele): Rank Country AD Rate E4 Allele rate 1 FINLAND 53.77 0.215 2 USA 45.58 0.110 3 CANADA 35.5 0.150 4 ICELAND 34.08 0.164 5 SWEDEN 32.41 0.205 6 SWITZERLAND 32.25 0.109 7...
by Harrison
Fri Jun 09, 2017 12:27 pm
Forum: Prevention and Treatment
Topic: How Not to Die
Replies: 17
Views: 1091

Re: How Not to Die

Regarding the Yoruba study, they only looked at confirmed AD cases, so lifespan is not an issue. As I mentioned in a previous post, E4/4 in the Yoruba population had the same chance of developing AD as E4/4 African-Americans in Indianapolis. The diet/lifestyle component seemed to make a difference f...
by Harrison
Tue Jun 06, 2017 11:50 am
Forum: Announcements and Events
Topic: The Dynamic Brain Conference in LA this Summer
Replies: 76
Views: 4856

Re: The Dynamic Brain Conference in LA this Summer

Found Tanzi's slides. He basically says that plaques come first and then trigger the tangles that kill nerve cells. Via his "Alzheimer's in a dish", they've observed: 1.) Plaques arise in the brain pre‐symptomatically. 2.) Tangles form and spread through the brain killing neurons. 3. Neur...
by Harrison
Mon Jun 05, 2017 2:17 pm
Forum: Announcements and Events
Topic: The Dynamic Brain Conference in LA this Summer
Replies: 76
Views: 4856

Re: The Dynamic Brain Conference in LA this Summer

I might be misunderstanding something, but I don't really understand the statement that Abeta progresses to tau. These are two completely separate proteins. Did Tanzi says something like this at the conference?: Tanzi compared the plaque formation — whether through amyloid beta’s 42 amino acid form ...
by Harrison
Wed May 24, 2017 9:49 am
Forum: Prevention and Treatment
Topic: How Not to Die
Replies: 17
Views: 1091

Re: How Not to Die

The point is well taken. My grandfather had dementia, but his cause of death was respiratory failure. At least for the Yoruba study, the authors did their best: Clinical evaluations included (1) a cognitive assessment adapted from the Consortium to Establish a Registry of Alzheimer’s Disease (CERAD)...
by Harrison
Tue May 23, 2017 11:42 am
Forum: Prevention and Treatment
Topic: How Not to Die
Replies: 17
Views: 1091

Re: How Not to Die

I really appreciate Denise Munger's detailed critiques of these types of books. I'm surprised that she didn't call out the fact that Greger's references for apoE were from the late 1980s and 1990s! One of the publications Greger cited (indirectly) came from 1995 and said that Yoruba Nigerians had a ...

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