I'm thinking we could meet at Peet's Coffee just south of San Rafael, at 276 Bon Air Center, Greenbrae, CA 94904 for our Sunday, October 13th, 2019 10 am Meet-Up?

Kick Alzheimer's Rear End - KARE

Welcome Charlie! I was listening to a Dave Asprey podcast with Paul Saladino MD, a doc who advocates carnivore. Near the end of the interview, Dave asked Paul something like, "people listening have heard Dr. Gundry, they've heard me talk about my Bulletproof diet and now you are advocating nos...

Hi Data, from another 4/4. Welcome! I hear Captain Picard is getting back in the act...

In terms of what we can do to promote the glymphatic system, Matthew Walker, PhD., author of "Why We Sleep" claims that deep NREM sleep provides a pulsing rhythm that promotes a ten to twentyfold increase in "efluent expulsion" from the brain. The purifying work of the glympahti...

I hope Oura will come out with a minipetite version for my little fingers. Some say that bands around one's wrist (along with tight bras, waistbands and the like) impede lymph flow. Don't know how big of a potential issue that is, but I'm all about lymph :D They do have quite a few different sizes...

Here is a good article that discusses both glucose and ketone metabolism in the brain. http://www.jneurosci.org/content/38/30/6665 I use evolution of man to try to understand the ApoE gene and its various forms. What was man eating when E4 was the only version? During the period when Man's brain was...

In my mind, this does not show that lifestyle changes are futile for E4s. Perhaps we need more and earlier lifestyle improvements than E3s for the same cognitive benefit, and E3s need more lifestyle improvements than E2s. Just like we require more omega-3s than E3s. Recent studies are showing that ...

Except E4 seems to improve ketone metabolism in the brain. And remember that at one time E4 is all that there was. I find it hard to accept that it would be harmful in itself, at least in early man...prior to man moving from mostly meat and fat to having a good portion of carbs, and especially sugar...

b) in addition to ApoE status, 27 other genes were taken into account in establishing a polygenic risk score. I can provide the genes, and snps if there is interest. There is nothing that jumped out at me that is out of the ordinary I think you have this wrong - the earlier UK study that compared g...