jmac, That is interesting. Different side effects for different people. You may now discover that others also share the same experience. Mountaineermd.

Somedude. Thank you for your input. If I find a supplement with melatonin that helps me sleep and does't cause the watery diarrhea side effect, I will post a follow up. My initial post on this subject was to inform anyone who was experiencing persistent watery diarrhea and have been using a melatoni...

Somedud. I threw out the original oral supplements which caused the initial bouts of watery diarrhea, so I can't comment on wether they contained other additives. I do know that the melatonin skin patches don't cause diarrhea, but also don't really have much effect on my sleep. So my struggle to fin...

A further update from my original post. As a 70 yo ApoE4/3 I have struggled with insomnia. Original I was taking an oral melatonin supplements which I eventually realized was causing persistent watery diarrhea, which resolved when I stopped the supplements. I eventually tried a melatonin sublingual ...

Unfortunate update. After a week of sublingual melatonin spray, the benefits are waning and the watery diarrhea is stating to come on. So it's a no more melatonin in any route for me. My optimism was premature and did stand up to the test of time, Robert Johnson MD

A solution for the melatonin- diarrhea connection? I am the original author of this post which has now been read by over 30000 viewer. I am on this site because I have one copy of ApoE4 and my mother had severe AD. I have been practicing a healthy life style with diet and exercise. In hope of improv...

To reiterate the message of my original post, IF you are taking a melatonin supplement and you develop persistent watery diarrhea, STOP taking melatonin as that is the likely cause of the diarrhea. Robert Johnson MD

The stories are all very similar. I remember how relieved I was when I finally discovered the cause was a side effect from melatonin supplements. I know that it is a naturally occurring hormone, but taking it orally must be the issue. And I have no idea what the incidence of this side effect is, but...

Benson, I do not remember stomach growling as a significant part of my symptoms. My experience was relentless, persistent watery diarrhea, worse in the morning. No fever, no pain. The original article said it could take up to six weeks. Mountaineermd.

I suspect that it is melatonin itself that causes the watery diarrhea. I have take magnesium supplements without any diarrhea, yet my melatonin experience led me to initiate the experience on this site. I happen to be Apoe3/4, but I doubt there is any relation to ones Apoe status.