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by Verax
Thu Apr 04, 2019 7:02 pm
Forum: Science and Research
Topic: Amyloid beta found in cataracts
Replies: 1
Views: 200

Amyloid beta found in cataracts

Amyloid found in human cataracts with two-dimensional infrared spectroscopy Abstract: UV light and other factors damage crystallin proteins in the eye lens, resulting in cataracts that scatter light and affect vision. Little information exists about protein structures within these disease-causing a...
by Verax
Sun Mar 31, 2019 3:10 pm
Forum: Prevention and Treatment
Topic: L-serine research
Replies: 16
Views: 2182

Re: L-serine research

Maybe zinc works like serine? https://www.clinicaltrials.gov/ct2/show/NCT01259050 . But I don't understand the applicability to AD, as Cox's research points to a motor neuron disease, ALS, or Lytico-bodig disease, and the description from Guam of connection to BMAA is a lytico paralysis ending in a ...
by Verax
Mon Nov 26, 2018 2:59 pm
Forum: Prevention and Treatment
Topic: Duty to inform family?
Replies: 3
Views: 504

Re: Duty to inform family?

As part of the Generation 2 prevention clinical trial, I was told my E3/E4 test results by a physician along with the required brief encounter (over the phone from Amsterdam) with a certified genetic counselor. She didn't really add anything to what 23andMe had told me about my risk, perhaps 20-30% ...
by Verax
Sun Nov 25, 2018 5:38 pm
Forum: Prevention and Treatment
Topic: Duty to inform family?
Replies: 3
Views: 504

Duty to inform family?

(Sorry if this has been discussed, I searched but couldn't find this topic, so starting a new one.) 1. Is there a legal or moral duty to inform family members of APOE4 carriers? 2. Should there be? 3. Should it override patient confidentiality? 4. Should doctors be legally allowed or even required t...
by Verax
Thu Oct 11, 2018 1:38 pm
Forum: Science and Research
Topic: Is ApoE4 Neanderthal?
Replies: 43
Views: 3973

Re: Is ApoE4 Neanderthal?

Since the ancestral ApoE4 is preserved in about 15% of modern humans, there must be some evolutionary advantage, else prevalence would be smaller and recede. ApoE4 is thought to modulate immunity and to increase Vitamin D levels more than the other alleles. ApoE4 prevalence is higher at higher latit...
by Verax
Thu Oct 11, 2018 8:35 am
Forum: Science and Research
Topic: Periodontitis and sporadic Alzheimer's in mice
Replies: 3
Views: 537

Re: Periodontitis and sporadic Alzheimer's in mice

Do US dental professional organizations and licensing requirements erect barriers to meeting the vast unmet needs of elderly and patients in care institutions? Dental hygienists complain that tests are too difficult in states such as California, that licenses cannot be transferred without unnecessar...
by Verax
Tue Oct 09, 2018 1:15 pm
Forum: Prevention and Treatment
Topic: What the Tests Don't Show
Replies: 5
Views: 619

Re: What the Tests Don't Show

In my previous life I worked in a hospital doing medical tests. One point overlooked in the article is the tendency of all of us to do more and more tests. But if the false positive rate on a test is 5% (typical, as the article says), then repeating the test multiplies the rate. If you do 20 tests, ...
by Verax
Tue Oct 09, 2018 12:48 pm
Forum: Science and Research
Topic: Is ApoE4 Neanderthal?
Replies: 43
Views: 3973

Re: Is ApoE4 Neanderthal?

Mike, one of the articles I referenced does give evidence that only humans have E4/E4, and that chimps and other primates do not have E4, they have a different form of the gene without alleles such as E4 or E3. Apparently humans were E4/E4 a million years ago but the ancestry of Neanderthals is stil...
by Verax
Tue Oct 09, 2018 12:46 pm
Forum: Science and Research
Topic: Is ApoE4 Neanderthal?
Replies: 43
Views: 3973

Re: Is ApoE4 Neanderthal?

Following up on this intriguing question about ApoE4 and 23andMe's report on Neanderthal genes, I see that 23andMe does give some scientific details, see https://permalinks.23andme.com/pdf/23-05_neanderthal_ancestry_inference.pdf which you can retrieve from your 23andMe Neanderthal report Scientific...
by Verax
Thu Oct 04, 2018 4:33 pm
Forum: Science and Research
Topic: Periodontitis and sporadic Alzheimer's in mice
Replies: 3
Views: 537

Periodontitis and sporadic Alzheimer's in mice

Periodontitis is associated with dementia and AD in cross-sectional and longitudinal studies. Nursing homes are full of demented patients with bad or missing teetch. Common infections have been associated with dementia and organisms have been found in the brain. It makes sense that chronic low-grade...

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