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by TelopeaBlue
Thu Dec 05, 2019 10:56 am
Forum: Our Stories
Topic: E4/E4 carrier new introduction
Replies: 6
Views: 787

Re: E4/E4 carrier new introduction

Any e4/e4 carriers in their 50's 60's or 70's on here that can give me some hope an encouragement? Thank you for reading! *waving* 58 y.o. E4 homozygote here. Cognitively intact (I believe) with an 82 y.o. mother who is at least E4 heterozygote and also cognitively intact. Our genes are not our des...
by TelopeaBlue
Mon Oct 21, 2019 6:22 pm
Forum: Science and Research
Topic: New study - alcohol and dementia risk
Replies: 3
Views: 701

Re: New study - alcohol and dementia risk

There was no association of alcohol use with dementia risk in APOE4 carriers…in fact the risk ratio was nearly flat across the 4 categories of alcohol intake. Curious. Hazard Ratios: # drinks/week none…..0.1-0.9…..1-7…..7.1-14…..14+ APOE E4 + 0.93……ref=1…….0.74…...0.77…...0.77 APOE E4 - 1.27……ref=1...
by TelopeaBlue
Sat Oct 12, 2019 8:54 am
Forum: Science and Research
Topic: Link between walking speed and brain function
Replies: 1
Views: 458

Link between walking speed and brain function

No mention of ApoE in this open source paper but a correlation that may be interesting to our community regardless. Question Is gait speed measured at age 45 years associated with accelerated biological aging, neurocognitive function, and cognitive decline? Findings In this 5-decade cohort study of ...
by TelopeaBlue
Thu Sep 12, 2019 2:35 pm
Forum: Science and Research
Topic: Markers associated with genetic resililience to AD in E4/E4's
Replies: 8
Views: 1047

Re: Markers associated with genetic resililience to AD in E4/E4's

They found 2 SNP's that seemed to have "strong evidence" for resilience (CASP7 rs10553596 and SERPINA3 rs4934-A/A). Thanks for posting broiler, I checked on my Promethease results (from my 23&me data), and it didn't have the CASP7 one and for the SERPINA3 it states: "rs4934 incre...
by TelopeaBlue
Thu Sep 12, 2019 12:50 pm
Forum: Science and Research
Topic: Gene mutation evolved to cope with modern high-sugar diets
Replies: 8
Views: 1717

Re: Gene mutation evolved to cope with modern high-sugar diets

I wasn't able to find the CLTCL1 variant information in my genetic reports. Snpedia says its rs1061325 and it is available in my 23andme report. I'm a C/T so it (along with who knows what other snps) might help explain some issues I have with a high fat diet. I seem to need more carbs to feel my be...
by TelopeaBlue
Mon Sep 09, 2019 8:03 am
Forum: Our Stories
Topic: Little freaked out, but I suppose it's normal.
Replies: 5
Views: 697

Re: Little freaked out, but I suppose it's normal.

So yes, knew this was a possibility for 20 years, but confirmation of risk feels like a whole different thing! Looking forward to chatting with you and reading up on all of your good information. Glad this exists. Hi and welcome. Your subject line says it all I think. It was certainly my response, ...
by TelopeaBlue
Wed Aug 28, 2019 12:33 pm
Forum: Science and Research
Topic: APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's
Replies: 6
Views: 1264

Re: APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's

Anyone seen this or have comments? APOE4 Carriers Have Memory Problems Before the Onset of Alzheimer's Impaired memory-guided attention in asymptomatic APOE4 carriers I don't know about that paper, but coincidentally I got an email yesterday from MindCrowd about a study I participated in (I have no...
by TelopeaBlue
Wed Aug 28, 2019 12:17 pm
Forum: Science and Research
Topic: Lifestyle changes may not help Apoe4s
Replies: 14
Views: 2099

Re: Lifestyle changes may not help Apoe4s

I read the article, then clicked to look at the study. I wasn't willing to spend $9 to read it. I would like to find out exactly what kind of lifestyle they considered healthy. I will go back and re-read the article closer but think the study is going to go into the kind of details I'm interested i...
by TelopeaBlue
Fri Aug 23, 2019 5:22 pm
Forum: The Social Hour
Topic: Shock news from 23and me.
Replies: 21
Views: 6859

Re: Shock news from 23and me.

Iv`e just had a new report from 23and me. Apparently I have a 22 percent risk of type 2 diabetes on top of all the other diseases that I`m predisposed to. It seems that alzheimers, age related macular degeneration and coeliac disease weren`t enough, Mother nature decided to dump something else on m...
by TelopeaBlue
Fri Aug 23, 2019 5:02 pm
Forum: Our Stories
Topic: 26 and 4/4
Replies: 11
Views: 1593

Re: 26 and 4/4

Hello, I am new here so I apologize if I break any site rules. I just recently found out that I am 4/4 and I am very scared. Finding out at this age gives me lots of time for prevention, right? Someone please offer me some advice - I feel as if I have rec'd a death sentence. Hi there rara93, welcom...

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