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by broiler_x
Wed Jul 29, 2020 8:09 am
Forum: Science and Research
Topic: Potential New Blood Test for Early Detection of AD
Replies: 0
Views: 167

Potential New Blood Test for Early Detection of AD

Just published in JAMA are results from a large study examining a blood marker for early detection of Alzheimer Disease. The marker is P-tau217, and it appears to be elevated up to 20 years before any symptoms. Surprisingly, no mention of ApoE status of the participants. Here's the paper: https://ja...
by broiler_x
Thu Jan 30, 2020 1:42 pm
Forum: Science and Research
Topic: NIH grants Gladstone Institute $4.8M to study ApoE4
Replies: 2
Views: 509

NIH grants Gladstone Institute $4.8M to study ApoE4

https://www.biospace.com/article/-nih-f ... s-disease/

They're going to look at proteins that specifically interact with ApoE4 (or fragments thereof). I don't see a lot of research specifically aimed at ApoE4, so this is nice to see.
by broiler_x
Thu Jan 02, 2020 2:02 pm
Forum: Science and Research
Topic: STAT: “ The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades”
Replies: 5
Views: 1382

Re: STAT: “ The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades”

Having been in the trenches in research around the amyloid hypothesis heyday in the mid-2000's, I don't really think there was a concerted effort to ignore all other possibilities. That's just typical of science in general. The "hot" hypothesis gets all of the attention (and funds). The da...
by broiler_x
Thu Jan 02, 2020 1:48 pm
Forum: Prevention and Treatment
Topic: Alzheimer's Cured by Methylene Blue Celebration Thread!
Replies: 12
Views: 2178

Re: Alzheimer's Cured by Methylene Blue Celebration Thread!

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial...
by broiler_x
Thu Jan 02, 2020 1:19 pm
Forum: Prevention and Treatment
Topic: Alzheimer's Cured by Methylene Blue Celebration Thread!
Replies: 12
Views: 2178

Re: Alzheimer's Cured by Methylene Blue Celebration Thread!

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial ...
by broiler_x
Fri Nov 22, 2019 3:16 pm
Forum: Prevention and Treatment
Topic: Spouse with early stage ALZ resists Bredesen diet what do I do?
Replies: 7
Views: 1114

Re: Spouse with early stage ALZ resists Bredesen diet what do I do?

Trying to change someone is near impossible - especially when they are a relative. For some reason we trust stranger's advice much more than someone who loves and cares for us. I've dealt with this personally with a brother-in-law who decided to treat his cancer solely through naturopathic methods a...
by broiler_x
Tue Nov 05, 2019 10:50 am
Forum: Science and Research
Topic: Genetic Mutation of ApoE protects against AD
Replies: 8
Views: 1231

Re: Genetic Mutation of ApoE protects against AD

Oh, and here's an article about this research that is accessible without a fee:

https://news.yahoo.com/why-didnt-she-al ... Redirect=1
by broiler_x
Tue Nov 05, 2019 10:49 am
Forum: Science and Research
Topic: Genetic Mutation of ApoE protects against AD
Replies: 8
Views: 1231

Re: Genetic Mutation of ApoE protects against AD

I saw this as well, very interesting finding. It was published in Nature Medicine which would indicate that the experts think this is very high impact research. This will be interesting to follow. And yes, another nail in the coffin of the amyloid hypothesis - how many nails does it take to seal a c...
by broiler_x
Fri Nov 01, 2019 7:47 am
Forum: Prevention and Treatment
Topic: New paper: Individualized clinical management of patients at risk for Alzheimer's dementia
Replies: 1
Views: 618

Re: New paper: Individualized clinical management of patients at risk for Alzheimer's dementia

This is a very promising study and the first clinical study to show cognitive improvement via lifestyle changes in those at risk for Alzheimer's. Here's a an article about the study written more for the lay person: https://www.cnn.com/2019/10/30/health/alzheimers-lifestyle-changes-improved-memory-we...
by broiler_x
Wed Oct 23, 2019 3:33 pm
Forum: Science and Research
Topic: halting Phase III trials of aducanumab
Replies: 17
Views: 3326

Re: halting Phase III trials of aducanumab

I am very dubious about this, but I am in the minority as Biogen's stock price rocketed up on this news. Large companies don't abandon huge, expensive trials out of "futility" unless there is a substantial reason too. And their stock price took a huge hit when they announced that bad news....

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