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by broiler_x
Thu Jul 25, 2019 8:23 am
Forum: Science and Research
Topic: Ketogenic diet - single case study
Replies: 1
Views: 263

Ketogenic diet - single case study

This is just an n=1, but it looks promising. A 71 yo female heterozygous for ApoE4 displaying mild AD responded well to a ketogenic diet and saw improved blood markers as well as significantly improved cognition. https://www.ncbi.nlm.nih.gov/pubmed/31336463 Ketogenic diet rescues cognition in ApoE4+...
by broiler_x
Tue Jun 11, 2019 9:22 am
Forum: Science and Research
Topic: Proof that MCT causes insulin resistance?
Replies: 25
Views: 4163

Re: Proof that MCT causes insulin resistance?

I realize that this is an older thread that got bumped up, but I have to comment. I find the original cited article to be very weak. Too small of sample size, too short of a time period, and my god, look at those error bars! This was published in 2012, and I can find no follow-up research on this to...
by broiler_x
Wed Jun 05, 2019 11:36 am
Forum: Science and Research
Topic: Pfizer 's anti-inflammatory drug questions (revised title)
Replies: 25
Views: 1246

Re: Pfizer buried promising lead on its anti-inflammatory drug

I've been following this story. I don't fault Pfizer for not pursuing this, it doesn't sound like there was enough of a positive signal to warrant the cost of a PhIII clinical trial. Those trials are really expensive, especially for AD due to the necessary long duration and high mortality of the age...
by broiler_x
Fri Apr 19, 2019 12:18 pm
Forum: Our Stories
Topic: New to group
Replies: 7
Views: 521

Re: New to Group Floramaria questions

I use store-bought olive oil mayonnaise for my tuna salad, smoked trout salad and egg salad. Watch out for that store bought olive oil mayonnaise. I was doing the same thing thinking I was being smart, but then I looked at the ingredients. The first ingredient was indeed olive oil, but the second i...
by broiler_x
Thu Apr 11, 2019 2:15 pm
Forum: Our Stories
Topic: Newbie Here in San Diego
Replies: 9
Views: 617

Re: Newbie Here in San Diego

I've experimented with Keto but it is actually not good for my type 3/4 and with my cholesterol issues. I'm 4/4 and also had cholesterol issues. 3 years ago, my LDL was at 190 and my doctor wanted to put me on a statin. I told him I'd research the subject before going on a medication and what I fou...
by broiler_x
Thu Mar 21, 2019 10:27 am
Forum: Prevention and Treatment
Topic: Another Major Drug Trial Failure
Replies: 5
Views: 415

Re: Another Major Drug Trial Failure

Biogen stock is down about 30% today as the company abandons its phase three trial for Aducanumab. This was considered to be a potential blockbuster drug for the treatment of AD. The drug is an antibody treatment for the removal of AB. I guess this result should not be a great surprise considering ...
by broiler_x
Fri Mar 08, 2019 2:11 pm
Forum: Science and Research
Topic: New comprehensive review on ApoE and Alzheimer's
Replies: 9
Views: 780

Re: New comprehensive review on ApoE and Alzheimer's

Thanks - very nice review. Also, this is the best map I've seen of the World distribution of ApoE4. It is much different than I had imagined from other descriptions. Sub-saharan Africa has the most. Middle East has the least. Europe goes from medium in the south to higher in the north. Malaysia and...
by broiler_x
Fri Mar 08, 2019 8:05 am
Forum: Science and Research
Topic: New comprehensive review on ApoE and Alzheimer's
Replies: 9
Views: 780

New comprehensive review on ApoE and Alzheimer's

https://www.cell.com/neuron/fulltext/S0896-6273(19)30083-2 This is a long, comprehensive review of ApoE and Alzheimer's that was just published in Neuron. PDF is free! Neuron. 2019 Mar 6;101(5):820-838. doi: 10.1016/j.neuron.2019.01.056. A Quarter Century of APOE and Alzheimer's Disease: Progress t...
by broiler_x
Tue Jan 22, 2019 9:48 am
Forum: Our Stories
Topic: New member needing support
Replies: 7
Views: 701

Re: New member needing support

Welcome Ben! I think the "natural approach" is a great way to go, and given that there is no clinically proven drug that will do anything besides temporarily mask symptoms, it's really the only way to go. And this is coming from a molecular biologist who has been involved in drug discovery...

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