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by broiler_x
Wed Dec 02, 2020 10:33 am
Forum: Science and Research
Topic: High glycemic load meals associated with cognitive decline in E4 carriers
Replies: 0
Views: 277

High glycemic load meals associated with cognitive decline in E4 carriers

This is nothing new, but it's always good to get confirmation! Also, this is a long-term study with many participants. For those that don't know, "glycemic load" is essentially eating a lot of carbs (more technically, something that you ingest that raises your blood glucose). In this study...
by broiler_x
Mon Nov 30, 2020 10:42 am
Forum: Science and Research
Topic: Dr. Peter Attia podcast on Alzheimer’s disease prevention
Replies: 13
Views: 1644

Re: Dr. Peter Attia podcast on Alzheimer’s disease prevention

I listened to this over the weekend, and it is fantastic! A lot of ApoE4-specific content. It's quite long (>2 hours), but worth it.
by broiler_x
Wed Jul 29, 2020 8:09 am
Forum: Science and Research
Topic: Potential New Blood Test for Early Detection of AD
Replies: 0
Views: 291

Potential New Blood Test for Early Detection of AD

Just published in JAMA are results from a large study examining a blood marker for early detection of Alzheimer Disease. The marker is P-tau217, and it appears to be elevated up to 20 years before any symptoms. Surprisingly, no mention of ApoE status of the participants. Here's the paper: https://ja...
by broiler_x
Thu Jan 30, 2020 1:42 pm
Forum: Science and Research
Topic: NIH grants Gladstone Institute $4.8M to study ApoE4
Replies: 2
Views: 747

NIH grants Gladstone Institute $4.8M to study ApoE4

https://www.biospace.com/article/-nih-f ... s-disease/

They're going to look at proteins that specifically interact with ApoE4 (or fragments thereof). I don't see a lot of research specifically aimed at ApoE4, so this is nice to see.
by broiler_x
Thu Jan 02, 2020 2:02 pm
Forum: Science and Research
Topic: STAT: “ The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades”
Replies: 5
Views: 1706

Re: STAT: “ The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades”

Having been in the trenches in research around the amyloid hypothesis heyday in the mid-2000's, I don't really think there was a concerted effort to ignore all other possibilities. That's just typical of science in general. The "hot" hypothesis gets all of the attention (and funds). The da...
by broiler_x
Thu Jan 02, 2020 1:48 pm
Forum: Prevention and Treatment
Topic: Alzheimer's Cured by Methylene Blue Celebration Thread!
Replies: 16
Views: 3757

Re: Alzheimer's Cured by Methylene Blue Celebration Thread!

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial...
by broiler_x
Thu Jan 02, 2020 1:19 pm
Forum: Prevention and Treatment
Topic: Alzheimer's Cured by Methylene Blue Celebration Thread!
Replies: 16
Views: 3757

Re: Alzheimer's Cured by Methylene Blue Celebration Thread!

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial ...
by broiler_x
Fri Nov 22, 2019 3:16 pm
Forum: Prevention and Treatment
Topic: Spouse with early stage ALZ resists Bredesen diet what do I do?
Replies: 7
Views: 1554

Re: Spouse with early stage ALZ resists Bredesen diet what do I do?

Trying to change someone is near impossible - especially when they are a relative. For some reason we trust stranger's advice much more than someone who loves and cares for us. I've dealt with this personally with a brother-in-law who decided to treat his cancer solely through naturopathic methods a...
by broiler_x
Tue Nov 05, 2019 10:50 am
Forum: Science and Research
Topic: Genetic Mutation of ApoE protects against AD
Replies: 8
Views: 1676

Re: Genetic Mutation of ApoE protects against AD

Oh, and here's an article about this research that is accessible without a fee:

https://news.yahoo.com/why-didnt-she-al ... Redirect=1
by broiler_x
Tue Nov 05, 2019 10:49 am
Forum: Science and Research
Topic: Genetic Mutation of ApoE protects against AD
Replies: 8
Views: 1676

Re: Genetic Mutation of ApoE protects against AD

I saw this as well, very interesting finding. It was published in Nature Medicine which would indicate that the experts think this is very high impact research. This will be interesting to follow. And yes, another nail in the coffin of the amyloid hypothesis - how many nails does it take to seal a c...

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