Just published in JAMA are results from a large study examining a blood marker for early detection of Alzheimer Disease. The marker is P-tau217, and it appears to be elevated up to 20 years before any symptoms. Surprisingly, no mention of ApoE status of the participants. Here's the paper: https://ja...

https://www.biospace.com/article/-nih-f ... s-disease/

They're going to look at proteins that specifically interact with ApoE4 (or fragments thereof). I don't see a lot of research specifically aimed at ApoE4, so this is nice to see.

Having been in the trenches in research around the amyloid hypothesis heyday in the mid-2000's, I don't really think there was a concerted effort to ignore all other possibilities. That's just typical of science in general. The "hot" hypothesis gets all of the attention (and funds). The da...

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial...

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial ...

Trying to change someone is near impossible - especially when they are a relative. For some reason we trust stranger's advice much more than someone who loves and cares for us. I've dealt with this personally with a brother-in-law who decided to treat his cancer solely through naturopathic methods a...

Oh, and here's an article about this research that is accessible without a fee:

https://news.yahoo.com/why-didnt-she-al ... Redirect=1

I saw this as well, very interesting finding. It was published in Nature Medicine which would indicate that the experts think this is very high impact research. This will be interesting to follow. And yes, another nail in the coffin of the amyloid hypothesis - how many nails does it take to seal a c...

This is a very promising study and the first clinical study to show cognitive improvement via lifestyle changes in those at risk for Alzheimer's. Here's a an article about the study written more for the lay person: https://www.cnn.com/2019/10/30/health/alzheimers-lifestyle-changes-improved-memory-we...

I am very dubious about this, but I am in the minority as Biogen's stock price rocketed up on this news. Large companies don't abandon huge, expensive trials out of "futility" unless there is a substantial reason too. And their stock price took a huge hit when they announced that bad news....