This is just an n=1, but it looks promising. A 71 yo female heterozygous for ApoE4 displaying mild AD responded well to a ketogenic diet and saw improved blood markers as well as significantly improved cognition. https://www.ncbi.nlm.nih.gov/pubmed/31336463 Ketogenic diet rescues cognition in ApoE4+...

I realize that this is an older thread that got bumped up, but I have to comment. I find the original cited article to be very weak. Too small of sample size, too short of a time period, and my god, look at those error bars! This was published in 2012, and I can find no follow-up research on this to...

I've been following this story. I don't fault Pfizer for not pursuing this, it doesn't sound like there was enough of a positive signal to warrant the cost of a PhIII clinical trial. Those trials are really expensive, especially for AD due to the necessary long duration and high mortality of the age...

I use store-bought olive oil mayonnaise for my tuna salad, smoked trout salad and egg salad. Watch out for that store bought olive oil mayonnaise. I was doing the same thing thinking I was being smart, but then I looked at the ingredients. The first ingredient was indeed olive oil, but the second i...

I've experimented with Keto but it is actually not good for my type 3/4 and with my cholesterol issues. I'm 4/4 and also had cholesterol issues. 3 years ago, my LDL was at 190 and my doctor wanted to put me on a statin. I told him I'd research the subject before going on a medication and what I fou...

Biogen stock is down about 30% today as the company abandons its phase three trial for Aducanumab. This was considered to be a potential blockbuster drug for the treatment of AD. The drug is an antibody treatment for the removal of AB. I guess this result should not be a great surprise considering ...

Thanks - very nice review. Also, this is the best map I've seen of the World distribution of ApoE4. It is much different than I had imagined from other descriptions. Sub-saharan Africa has the most. Middle East has the least. Europe goes from medium in the south to higher in the north. Malaysia and...

https://www.cell.com/neuron/fulltext/S0896-6273(19)30083-2 This is a long, comprehensive review of ApoE and Alzheimer's that was just published in Neuron. PDF is free! Neuron. 2019 Mar 6;101(5):820-838. doi: 10.1016/j.neuron.2019.01.056. A Quarter Century of APOE and Alzheimer's Disease: Progress t...

Welcome Ben! I think the "natural approach" is a great way to go, and given that there is no clinically proven drug that will do anything besides temporarily mask symptoms, it's really the only way to go. And this is coming from a molecular biologist who has been involved in drug discovery...

https://www.biospace.com/article/possib ... dentified/

Early stage research, but looks pretty sound.