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by broiler_x
Thu Feb 04, 2021 2:40 pm
Forum: Prevention and Treatment
Topic: Deep Sleep 4/4
Replies: 15
Views: 1212

Re: Deep Sleep 4/4

I also got an Oura ring about 3 months ago, and I've been having fun performing experiments on myself to see what affects my sleep! Deep sleep normally happens in the first third of the night, starting soon after you go to bed. So I find it's very important what you're routine is right before bed. F...
by broiler_x
Tue Feb 02, 2021 9:22 am
Forum: Prevention and Treatment
Topic: Peter Attia's latest podcast: Deep dive into APOE, Alzheimer's and brain health
Replies: 7
Views: 897

Re: Peter Attia's latest podcast: Deep dive into APOE, Alzheimer's and brain health

I finished it this morning (it's a little over 2 hours). If you're just interested in the practical advice, it all comes in the last 20 minutes or so. The guest is a very conservative scientist, which I love. For example, he states that consumption of DHA-rich fatty fish does appear to reduce likeli...
by broiler_x
Mon Feb 01, 2021 8:55 am
Forum: Prevention and Treatment
Topic: Peter Attia's latest podcast: Deep dive into APOE, Alzheimer's and brain health
Replies: 7
Views: 897

Peter Attia's latest podcast: Deep dive into APOE, Alzheimer's and brain health

I'm about a third of the way into this podcast, and so far it is excellent.

https://peterattiamd.com/husseinyassine/

Just came out today (Feb.1 2021).
by broiler_x
Wed Dec 02, 2020 10:33 am
Forum: Science and Research
Topic: High glycemic load meals associated with cognitive decline in E4 carriers
Replies: 0
Views: 429

High glycemic load meals associated with cognitive decline in E4 carriers

This is nothing new, but it's always good to get confirmation! Also, this is a long-term study with many participants. For those that don't know, "glycemic load" is essentially eating a lot of carbs (more technically, something that you ingest that raises your blood glucose). In this study...
by broiler_x
Mon Nov 30, 2020 10:42 am
Forum: Science and Research
Topic: Dr. Peter Attia podcast on Alzheimer’s disease prevention
Replies: 13
Views: 2331

Re: Dr. Peter Attia podcast on Alzheimer’s disease prevention

I listened to this over the weekend, and it is fantastic! A lot of ApoE4-specific content. It's quite long (>2 hours), but worth it.
by broiler_x
Wed Jul 29, 2020 8:09 am
Forum: Science and Research
Topic: Potential New Blood Test for Early Detection of AD
Replies: 0
Views: 374

Potential New Blood Test for Early Detection of AD

Just published in JAMA are results from a large study examining a blood marker for early detection of Alzheimer Disease. The marker is P-tau217, and it appears to be elevated up to 20 years before any symptoms. Surprisingly, no mention of ApoE status of the participants. Here's the paper: https://ja...
by broiler_x
Thu Jan 30, 2020 1:42 pm
Forum: Science and Research
Topic: NIH grants Gladstone Institute $4.8M to study ApoE4
Replies: 2
Views: 883

NIH grants Gladstone Institute $4.8M to study ApoE4

https://www.biospace.com/article/-nih-f ... s-disease/

They're going to look at proteins that specifically interact with ApoE4 (or fragments thereof). I don't see a lot of research specifically aimed at ApoE4, so this is nice to see.
by broiler_x
Thu Jan 02, 2020 2:02 pm
Forum: Science and Research
Topic: STAT: “ The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades”
Replies: 5
Views: 1933

Re: STAT: “ The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades”

Having been in the trenches in research around the amyloid hypothesis heyday in the mid-2000's, I don't really think there was a concerted effort to ignore all other possibilities. That's just typical of science in general. The "hot" hypothesis gets all of the attention (and funds). The da...
by broiler_x
Thu Jan 02, 2020 1:48 pm
Forum: Prevention and Treatment
Topic: Alzheimer's Cured by Methylene Blue Celebration Thread!
Replies: 22
Views: 5241

Re: Alzheimer's Cured by Methylene Blue Celebration Thread!

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial...
by broiler_x
Thu Jan 02, 2020 1:19 pm
Forum: Prevention and Treatment
Topic: Alzheimer's Cured by Methylene Blue Celebration Thread!
Replies: 22
Views: 5241

Re: Alzheimer's Cured by Methylene Blue Celebration Thread!

Why on earth did they do the trial where the control group was dosed at 8 mg/day? There had to be some rational reason, because these trials are very expensive to run. Sounds like a new trial does need to be done with better controls. I don't think the FDA could approve a treatment based on a trial ...

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