I actually think what he's gently saying, is that the science tells us that NOBODY can tolerate caffeine, irrespective of their genetic predisposition (and some metabolize less than others) and that it has an effect on everybody's sleep, whether we realize it or not. It's hard to reconcile Walker's...

Notwithstanding, the evidence suggests that a much higher protein intake among our overall human population would reduce sarcopenia and improve skeletal muscular function. Perhaps, but Dr. Bredesen would argue the majority of that evidence is based upon a very unhealthy Western population. So many ...

I'd imagine that's only if you metabolize caffeine. Some people don't have the gene to metabolize it (like me) and even a decaf Nespresso can affect sleep for up to two nights afterwards. Dr Matthew Walker, the sleep neuroscientist, is very negative about coffee in general; "Caffeine has a hal...

Issues with ApoE4 seem to show up mostly later in life. Wouldn't this be a life-long issue, if true? Yeah, and also not all E4s are affected, even homozygotes. From my perspective that gives validity to Brians's theory. I wonder about studies which indicate that APOE4 is just bad (rather than possi...

Thank you—this is great! Did Dr. Bredesen mention anything about decaffeinated coffee? Is it ok for E4's to drink? Sneak peek from the new book: Coffee is great, associated with longevity and better cognition. Keep it under 4 cups so as not to increase homocysteine and before noon. It really does a...

So only six lysine residues stand between me and AD? FWIW, this is from Mark Mattson, who many of us are familiar with from his caloric restriction work. You can read a press release here that helps to translate the scientific jargon. This looks interesting!

FWIW, Dr. B gives a thumbs up to organic tempeh and a thumbs down to pea protein or any protein powder or supplement. The idea is to get protein through whole foods. Despite the fact that it's processed, tempeh is a particularly good choice as it's fermented which will help to alleviate the inflamma...

I hate to not totally agree with Julie, since she knows so much more than I do (and thus, take my opinions with several grains of salt). LOL, pease disagree. I greatly respect your perspective, Brian! I didn't mean to imply that Dr. Bredesen insists on animal protein, but rather that his limit only...

I struggle to get enough protein (70g minimum, according to my nutritionist). If I get enough protein, I think I'll make my lipids worse and somewhat go against the Bredesen protocol. carriex3, welcome! That seems like a lot of protein to me. Dr. Bredesen recommends between 0.8-1.0 grams (g) per ki...

Thank you , Theresa! I'm pretty sure the fasting insulin was a misspeak and < 4.5 still stands. The A1c is correct. The new goal is <5.3. There will be other updated goals in the new book. Dr. Bredesen has long spoke of the other two subtypes (vascular & traumatic) but I guess they didn't make t...