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by Julie G
Wed Jan 16, 2019 1:44 pm
Forum: Science and Research
Topic: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'
Replies: 7
Views: 323

Re: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'

Sorry, that got long. Basically, cholesterol and triglycerides are often co-transported. So a malfunction in the uptake system leaves both doing laps throughout the circulatory system. Nice job, Fiver! The part that I’m still struggling to understand is your presumption that poor LDLr activity resu...
by Julie G
Wed Jan 16, 2019 9:34 am
Forum: Science and Research
Topic: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'
Replies: 7
Views: 323

Re: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'

I assumed - again, maybe incorrectly - that this higher circulating LDL was one of the links between AD and CVD in apoe4s. Plausible explanation for our higher LDL, but help us understand how this hypothesis relates to triglycerides . FWIW, it’s been assumed that our higher LDL is somehow linked to...
by Julie G
Wed Jan 16, 2019 8:59 am
Forum: Science and Research
Topic: Effects of APOE on nutritional metabolism in dementia
Replies: 2
Views: 128

Re: Effects of APOE on nutritional metabolism in dementia

Thanks, Ski! Rehashing old findings... Anybody see anything new?
by Julie G
Wed Jan 16, 2019 8:53 am
Forum: Science and Research
Topic: Maternal Inheritance
Replies: 17
Views: 470

Re: Maternal Inheritance

True, just a hypothesis. Here’s a recent paper discussing the evidence: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842281/ Patterns of inherited risk for AD also suggest a role for the maternally inherited mitochondria. Individuals with a maternal family history of AD have a higher risk of AD com...
by Julie G
Tue Jan 15, 2019 5:56 pm
Forum: Science and Research
Topic: Ketogenic Supplement Tricaprilin Fails in AD Trial
Replies: 19
Views: 1404

Re: Ketogenic Supplement Tricaprilin Fails in AD Trial

Actually, there has yet to be a trial of ketogenic diets or supplements to show a clear positive effect in AD patients or people at high risk. I recently came across this small trial that used nutritional ketosis (as opposed to a supplement) in a group with MCI. Unfortunately APOE status wasn't exa...
by Julie G
Tue Jan 15, 2019 12:58 pm
Forum: Science and Research
Topic: Maternal Inheritance
Replies: 17
Views: 470

Re: Maternal Inheritance

Would the same then apply if your dad's mother had AD?

Your dad (not you!) would be affected by his mother's mitochondria.
by Julie G
Tue Jan 15, 2019 11:48 am
Forum: Science and Research
Topic: Maternal Inheritance
Replies: 17
Views: 470

Re: Maternal Inheritance

So do you think that it may be the case that if dad has AD one is generally less likely to get it than if mom has it?

The literature overwhelmingly supports this view. Those with affected mothers are considered to be at higher risk.
by Julie G
Sun Jan 13, 2019 3:48 pm
Forum: Science and Research
Topic: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'
Replies: 7
Views: 323

Re: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'

Hey, Circ! We discussed a similar paper in this thread. Just last night, I ran across an assertion that very low triglycerides (especially under 50 mg/dl), are observed in patients who have toxicity-related Alzheimer's. Good observation, FF. It helps to think of triglycerides in terms of “energy.” H...
by Julie G
Sun Jan 13, 2019 9:24 am
Forum: Our Stories
Topic: Should I stop supplementing with b12?
Replies: 9
Views: 206

Re: Should I stop supplementing with b12?

Cognitive decline is associated with low "normal" B12. You can read more here. Dr. Bredesen's recommended levels are optimized to be neuroprotective.
by Julie G
Sun Jan 13, 2019 9:13 am
Forum: Our Stories
Topic: Conflicting Test Results
Replies: 6
Views: 389

Re: Conflicting Test Results

Thread link does not work.

Fixed above! Here it is: viewtopic.php?f=2&t=4785&hilit=ancestry.com Unless things have changed, Ancestry.com doesn't report APOE status.

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