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by BrianR
Sat Sep 12, 2020 2:09 pm
Forum: Meet-Ups
Topic: Virtual Book Club: The End of Alzheimer's Program
Replies: 40
Views: 2443

Re: Virtual Book Club: The End of Alzheimer's Program

I love the intimacy of a smaller group as well. As far as inviting Dr. Bredesen, my guess is that he'd prefer a larger group, but I could always suggest that he host his own larger book club if he likes the idea. As I recall, our Zoom accounts allows for breakout rooms if we ever decide we need the...
by BrianR
Sat Sep 12, 2020 2:02 pm
Forum: Prevention and Treatment
Topic: Does Black Coffee Break a Fast?
Replies: 9
Views: 642

Re: Does Black Coffee Break a Fast?

Note that coffee does contain fiber. So if part of your fasting discipline is making your gut microbiome go hungry for a bit too, then coffee will break that aspect of the fast. However, I doubt that there's much good science out there to guide you. (Although there are plenty of smart, scientificall...
by BrianR
Tue Aug 25, 2020 5:49 pm
Forum: Science and Research
Topic: Dementia: differentiate between LATE and frontotemporal dementia (FTD)
Replies: 0
Views: 140

Dementia: differentiate between LATE and frontotemporal dementia (FTD)

Science Daily interpretation: https://www.sciencedaily.com/releases/2020/08/200824123336.htm Working with their colleagues at the University of Pennsylvania, researchers at the University of Kentucky have found that they can differentiate between subtypes of dementia inducing brain disease. "Fo...
by BrianR
Sat Aug 15, 2020 9:02 am
Forum: Prevention and Treatment
Topic: Reformulating my supplement stack -- what is everyone else using these days?
Replies: 10
Views: 1079

Re: Reformulating my supplement stack -- what is everyone else using these days?

I see a couple of you mentioned zinc. Do you have a good brand recommendation That doesn’t overdo the dosage Nature's Plus sells a 10mg/pill formulation which you can buy on Amazon (and presumably other standard outlets). They say " Our Zinc is manufactured with the Biotron process of amino ac...
by BrianR
Sat Aug 08, 2020 5:20 pm
Forum: Science and Research
Topic: Somewhat OT: Sam Tsimikas Lp(a) "Twittorial"
Replies: 0
Views: 206

Somewhat OT: Sam Tsimikas Lp(a) "Twittorial"

Noted Lp(a) researcher Sam Tsimikas (@LPA_Doc) has started doing short tutorials regarding Lp(a) on twitter. Introductory thread quoted below Sam Tsimikas, MD @Lpa_Doc Saturday Morning Class: Hi all, with the increasing attention on Lp(a) and need for both patient and physician education, I decided ...
by BrianR
Fri Aug 07, 2020 9:08 am
Forum: Science and Research
Topic: Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment
Replies: 0
Views: 421

Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2769104 Key Points Question What are the comparative neurocognitive effects of an angiotensin receptor blocker, candesartan, and an angiotensin-converting enzyme inhibitor, lisinopril, on adults with hypertension and executive mild cogniti...
by BrianR
Sat Jun 13, 2020 1:40 pm
Forum: Science and Research
Topic: New Research on Blood Brain Barrier and APOE4
Replies: 10
Views: 1453

Re: New Research on Blood Brain Barrier and APOE4

Do you know what drug they were looking at? The paper is behind a paywall... I used SciHub to peek behind the paywall. Here are some extracts from the paper. Note their human cell work was apparently in vitro, so we'll have to see how their calcineurin inhibitors do in actual humans. (The inhibitor...
by BrianR
Tue May 26, 2020 5:39 pm
Forum: Science and Research
Topic: APOE4 protective against melanoma
Replies: 1
Views: 404

APOE4 protective against melanoma

Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depletion experiments showed that the effect of APOE genotype on melanoma progression wa...
by BrianR
Wed May 13, 2020 12:04 pm
Forum: Science and Research
Topic: Video: APOE4-associated vascular dysfunctions in both humans and animal models
Replies: 0
Views: 642

Video: APOE4-associated vascular dysfunctions in both humans and animal models

Alzheimer's Afternoons Seminar #14, May 12, Axel Montagne on Youtube Title: APOE4-associated vascular dysfunctions in both humans and animal models [With a focus in the Blood Brain Barrier] Speaker: Axel Montagne, PhD Institution: University of Southern California The tweet announcing this video sa...
by BrianR
Sun Apr 19, 2020 9:24 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2810

Re: Alzheimer's Afternoons Seminar Series Summaries

Fiver wrote:I wrote up my notes from these recent online seminars, for friends and colleagues (many of whom who are not experts in the field). Pasted here in case anyone is interested.

Fiver, these notes are wonderful! Thank you so much.

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