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by BrianR
Sat Jun 13, 2020 1:40 pm
Forum: Science and Research
Topic: New Research on Blood Brain Barrier and APOE4
Replies: 6
Views: 402

Re: New Research on Blood Brain Barrier and APOE4

Do you know what drug they were looking at? The paper is behind a paywall... I used SciHub to peek behind the paywall. Here are some extracts from the paper. Note their human cell work was apparently in vitro, so we'll have to see how their calcineurin inhibitors do in actual humans. (The inhibitor...
by BrianR
Tue May 26, 2020 5:39 pm
Forum: Science and Research
Topic: APOE4 protective against melanoma
Replies: 1
Views: 242

APOE4 protective against melanoma

Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depletion experiments showed that the effect of APOE genotype on melanoma progression wa...
by BrianR
Wed May 13, 2020 12:04 pm
Forum: Science and Research
Topic: Video: APOE4-associated vascular dysfunctions in both humans and animal models
Replies: 0
Views: 551

Video: APOE4-associated vascular dysfunctions in both humans and animal models

Alzheimer's Afternoons Seminar #14, May 12, Axel Montagne on Youtube Title: APOE4-associated vascular dysfunctions in both humans and animal models [With a focus in the Blood Brain Barrier] Speaker: Axel Montagne, PhD Institution: University of Southern California The tweet announcing this video sa...
by BrianR
Sun Apr 19, 2020 9:24 am
Forum: Science and Research
Topic: Alzheimer's Afternoons Seminar Series Summaries
Replies: 20
Views: 2004

Re: Alzheimer's Afternoons Seminar Series Summaries

Fiver wrote:I wrote up my notes from these recent online seminars, for friends and colleagues (many of whom who are not experts in the field). Pasted here in case anyone is interested.

Fiver, these notes are wonderful! Thank you so much.
by BrianR
Sat Apr 11, 2020 6:18 pm
Forum: Science and Research
Topic: In DIAN-TU, Gantenerumab Brings Down Tau. By a Lot.
Replies: 0
Views: 470

In DIAN-TU, Gantenerumab Brings Down Tau. By a Lot.

Interesting results from the DIAN-TU trial, as reported in alzforum. In DIAN-TU, Gantenerumab Brings Down Tau. By a Lot. Open Extension Planned ... But all is not lost for gantenerumab, a monoclonal targeting aggregated forms of Aβ. Besides removing amyloid plaques from the brain and normalizing CSF...
by BrianR
Fri Apr 03, 2020 4:56 pm
Forum: Science and Research
Topic: New series of very interesting articles on APOE4
Replies: 2
Views: 1214

Re: New series of very interesting articles on APOE4

Here is a full list of articles: APOE in Alzheimer's disease and neurodegeneration D. Allan Butterfield, Lance A. Johnson APOE in the normal brain Sarah A. Flowers, G. William Rebeck Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How Cutler T. Lew...
by BrianR
Thu Mar 26, 2020 5:02 pm
Forum: Science and Research
Topic: Extensive review: mTOR at the nexus of nutrition, growth, ageing and disease
Replies: 1
Views: 512

Extensive review: mTOR at the nexus of nutrition, growth, ageing and disease

For those who are particularly interested in understanding the mTOR pathway, this open access version of a Nature Reviews article should be quite useful. https://www.nature.com/articles/s41580-019-0199-y.epdf?shared_access_token=DeQUy7mxUc7EQrB8xuJ24dRgN0jAjWel9jnR3ZoTv0MIveQk5wMRmbsVdfWnsqcR28iC3Jh...
by BrianR
Tue Mar 10, 2020 6:12 pm
Forum: Prevention and Treatment
Topic: High Homocysteine Possible Deficiencies
Replies: 10
Views: 1321

Re: High Homocysteine Possible Deficiencies

Numerous medical journals have reported that taking doses of folate of 1 gram or more increase the chance of prostate cancer. Hmm, folate supplement or folic acid supplement? From https://www.cancer.gov/types/prostate/patient/prostate-prevention-pdq Folate is a kind of vitamin B that occurs natural...
by BrianR
Sun Mar 08, 2020 5:00 pm
Forum: Prevention and Treatment
Topic: rapamycin has harmful effects when telomeres are short
Replies: 0
Views: 266

rapamycin has harmful effects when telomeres are short

Interesting article/study. [Research done on "telomerase deficient mice". May or may not be relevant to aging humans.] Article: The CNIO discovers that rapamycin has harmful effects when telomeres are short https://www.eurekalert.org/pub_releases/2020-03/cndi-tcd022820.php Open access pape...
by BrianR
Thu Mar 05, 2020 4:10 pm
Forum: Science and Research
Topic: Alzheimer's: Can [l-serine] help restore memories?
Replies: 0
Views: 289

Alzheimer's: Can [l-serine] help restore memories?

Science Daily article: https://www.sciencedaily.com/releases/2020/03/200303113357.htm Research done in a mouse model of AD. The paywalled research paper is https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30063-2 Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contribut...

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