I love the intimacy of a smaller group as well. As far as inviting Dr. Bredesen, my guess is that he'd prefer a larger group, but I could always suggest that he host his own larger book club if he likes the idea. As I recall, our Zoom accounts allows for breakout rooms if we ever decide we need the...

Note that coffee does contain fiber. So if part of your fasting discipline is making your gut microbiome go hungry for a bit too, then coffee will break that aspect of the fast. However, I doubt that there's much good science out there to guide you. (Although there are plenty of smart, scientificall...

Science Daily interpretation: https://www.sciencedaily.com/releases/2020/08/200824123336.htm Working with their colleagues at the University of Pennsylvania, researchers at the University of Kentucky have found that they can differentiate between subtypes of dementia inducing brain disease. "Fo...

I see a couple of you mentioned zinc. Do you have a good brand recommendation That doesn’t overdo the dosage Nature's Plus sells a 10mg/pill formulation which you can buy on Amazon (and presumably other standard outlets). They say " Our Zinc is manufactured with the Biotron process of amino ac...

Noted Lp(a) researcher Sam Tsimikas (@LPA_Doc) has started doing short tutorials regarding Lp(a) on twitter. Introductory thread quoted below Sam Tsimikas, MD @Lpa_Doc Saturday Morning Class: Hi all, with the increasing attention on Lp(a) and need for both patient and physician education, I decided ...

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2769104 Key Points Question What are the comparative neurocognitive effects of an angiotensin receptor blocker, candesartan, and an angiotensin-converting enzyme inhibitor, lisinopril, on adults with hypertension and executive mild cogniti...

Do you know what drug they were looking at? The paper is behind a paywall... I used SciHub to peek behind the paywall. Here are some extracts from the paper. Note their human cell work was apparently in vitro, so we'll have to see how their calcineurin inhibitors do in actual humans. (The inhibitor...

Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depletion experiments showed that the effect of APOE genotype on melanoma progression wa...

Alzheimer's Afternoons Seminar #14, May 12, Axel Montagne on Youtube Title: APOE4-associated vascular dysfunctions in both humans and animal models [With a focus in the Blood Brain Barrier] Speaker: Axel Montagne, PhD Institution: University of Southern California The tweet announcing this video sa...

Fiver wrote:I wrote up my notes from these recent online seminars, for friends and colleagues (many of whom who are not experts in the field). Pasted here in case anyone is interested.

Fiver, these notes are wonderful! Thank you so much.