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by BrianR
Mon Nov 16, 2020 12:48 pm
Forum: Science and Research
Topic: Scientist focused podcast: AMiNDR: A Month in Neurodegenerative Disease Research
Replies: 1
Views: 194

Scientist focused podcast: AMiNDR: A Month in Neurodegenerative Disease Research

I ran across this podcast: https://amindr.com/ AMiNDR: A Month in Neurodegenerative Disease Research This is a podcast made by scientists for scientists, to help you save time so you can conduct better research. During each episode, the latest primary research articles in each topic for the past mon...
by BrianR
Thu Nov 05, 2020 10:55 am
Forum: Science and Research
Topic: Review: differences of patients with AD who are APOE4 carriers vs. those who are non-carriers
Replies: 1
Views: 347

Review: differences of patients with AD who are APOE4 carriers vs. those who are non-carriers

I thought this open access literature review was relatively readable (or at least, in my case, skimmable). https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00712-4 APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review....
by BrianR
Sun Nov 01, 2020 9:55 am
Forum: Prevention and Treatment
Topic: Higher Lung Cancer Risk Due to Vitamin B Supplementation?
Replies: 3
Views: 357

Re: Higher Lung Cancer Risk Due to Vitamin B Supplementation?

I believe other studies have shown that supplementation with Folic Acid can increase cancer risk. However, supplementation with Folate does not.
by BrianR
Sat Oct 31, 2020 4:08 pm
Forum: Science and Research
Topic: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
Replies: 23
Views: 2152

Re: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

This is an excellent podcast on the topic and how ketones can modulate the effect. The meat of the podcast on this topic starts around 57:00. (StemTalk Episode 114: Lilianne Mujica-Parodi talks about how diet and ketones affect brain aging) Thanks Tincup (and Fiver!). Tincup has referenced the Stem...
by BrianR
Sat Oct 24, 2020 12:13 pm
Forum: Science and Research
Topic: 4/4 centenarians?
Replies: 6
Views: 1107

Re: 4/4 centenarians?

NF52 previously posted a link to a paper which discussed the rs9536314 G/T genetic variant which provides extra KLOTHO which seems to be associated with extra longevity, even for APOE4 carriers. https://www.apoe4.info/forums/viewtopic.php?f=16&t=6051&p=66186#p75153 While looking into this qu...
by BrianR
Sat Oct 24, 2020 12:11 pm
Forum: Science and Research
Topic: [genetic variants for longevity] Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
Replies: 0
Views: 309

[genetic variants for longevity] Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

Open access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366647/ Multivariate genomic scan implicates novel loci and haem metabolism in human ageing Nat Commun. 2020; 11: 3570. Published online 2020 Jul 16. Paul R. H. J. Timmers [corresponding author], James F. Wilson, Peter K. Joshi [correspondin...
by BrianR
Sat Oct 24, 2020 10:03 am
Forum: Science and Research
Topic: reaction speed and brain health.
Replies: 2
Views: 481

Re: reaction speed and brain health.

Iv`e heard that faster reaction speeds are associated with good brain health. Is there any strong evidence to support this theory? Iv`e been wondering if taking up one of the martial arts would help protect against alzheimers. I know that fast reaction times helps prevent falls, which is another th...
by BrianR
Thu Oct 22, 2020 10:12 am
Forum: Prevention and Treatment
Topic: Phosphatidyl choline supplementation help needed
Replies: 3
Views: 327

Re: Phosphatidyl choline supplementation help needed

Can someone please explain a few things to me that I am struggling to get my head around... I know I need to take supplements to get choline as I can't get it from my diet. Which is best to take, choline or phosphatidyl choline? Chris Masterjohn has some useful information on this page: The Choline...
by BrianR
Thu Oct 22, 2020 9:16 am
Forum: Science and Research
Topic: APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
Replies: 23
Views: 2152

APOΕ4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

Open access preprint: https://www.biorxiv.org/content/10.1101/2020.10.19.345991v2 bioRxiv posted October 20, 2020. APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis Brandon C Farmer, ..., Lance A. Johnson doi: 10.1101/2020.10.19.345991 For th...
by BrianR
Tue Sep 29, 2020 5:17 pm
Forum: Science and Research
Topic: Research provides contrary results for Time Restricted Eating
Replies: 3
Views: 402

Research provides contrary results for Time Restricted Eating

One of Ethan Weiss's lab team ran a study on Time Restricted Eating in humans . The primary focus was weight loss, but they also looked at potential metabolic benefits. The results did not indicate value for TRE and did find statistically significant loss of lean muscle mass in the TRE group. This i...

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