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by BrianR
Thu Feb 06, 2020 4:58 pm
Forum: Prevention and Treatment
Topic: Trying to understand the Brain Blood Barrier
Replies: 3
Views: 207

Re: Trying to understand the Brain Blood Barrier

I've been on an asthma/allergy medication that's a leukotriene inhibitor, montelukast sodium aka Singulair for over a decade. Knowing that some asthma meds are now implicated in increased dementia risk due to being anticholinergic (benadryl, tiotropium bromide), I googled "singulair and dement...
by BrianR
Thu Feb 06, 2020 4:55 pm
Forum: Prevention and Treatment
Topic: Trying to understand the Brain Blood Barrier
Replies: 3
Views: 207

Re: Trying to understand the Brain Blood Barrier

Have you seen the Rhonda Patrick paper Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease in which she discusses [abstracting from the Abstract] "I propose that APOE4 carriers have impaired brain transport of free DHA but not of DHA-lysoPC, as a consequence of a ...
by BrianR
Thu Feb 06, 2020 4:50 pm
Forum: Prevention and Treatment
Topic: Two on Parkinson's Disease / APOE4 / Dementia, etc.
Replies: 1
Views: 178

Re: Two on Parkinson's Disease / APOE4 / Dementia, etc.

Link to the open access paper: https://stm.sciencemag.org/content/12/529/eaay3069 The work was done in a mouse model which had human variants for APOE (2/3/4), but the researchers did confirm their hypothesis to their satisfaction using a smallish study of human PD patients. The mice with APOE4 had ...
by BrianR
Wed Feb 05, 2020 9:45 am
Forum: Science and Research
Topic: AD Development May Be Thwarted by Certain Gene Variants [TREM2, ABCA7, SORL1, PSEN1 ... via PI3K/Akt/GSK-3β signaling pa
Replies: 0
Views: 172

AD Development May Be Thwarted by Certain Gene Variants [TREM2, ABCA7, SORL1, PSEN1 ... via PI3K/Akt/GSK-3β signaling pa

Interpretive article here: https://www.clinicalomics.com/topics/informatics-topic/alzheimers-disease-development-may-be-thwarted-by-certain-gene-variants/ An analysis of exome sequencing data from more than 10,000 individuals with late onset Alzheimer’s disease (AD; LOAD) suggests that natural varia...
by BrianR
Tue Feb 04, 2020 2:59 pm
Forum: Prevention and Treatment
Topic: Can Herpes Zoster ophthalmicus (Shingles) affect the Alzheimer's brain?
Replies: 13
Views: 686

Re: Can Herpes Zoster ophthalmicus (Shingles) affect the Alzheimer's brain?

slacker wrote:There have been shortages of the vaccine in the US.

Just to note that the Shingrix shortage seemed to have cleared up last year. I was able to get the vaccinations in the late summer/early fall of last year (2019) on a walk-in basis.
by BrianR
Sat Jan 25, 2020 4:15 pm
Forum: Science and Research
Topic: Can lithium halt progression of Alzheimer's disease?
Replies: 1
Views: 220

Can lithium halt progression of Alzheimer's disease?

Research done in a transgenic rat model for AD using a special formulation/encapsulation of lithium demonstrated improved cognitive abilities and decreases in amyloid beta. Open access Science Daily discussion: https://www.sciencedaily.com/releases/2020/01/200125090727.htm Summary : In a new study, ...
by BrianR
Wed Jan 22, 2020 11:39 am
Forum: Prevention and Treatment
Topic: Contract [supplement] manufacturer recalls products under more than 1,200 brand names
Replies: 6
Views: 512

Contract [supplement] manufacturer recalls products under more than 1,200 brand names

https://www.nutraingredients-usa.com/Article/2020/01/21/Contract-manufacturer-recalls-products-under-more-than-1-200-brand-names?utm_source=copyright&utm_medium=OnSite&utm_campaign=copyright FDA recall notice: https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/abh-natures-p...
by BrianR
Wed Jan 22, 2020 11:24 am
Forum: Science and Research
Topic: B12 and APOE4 - a gene-micronutrient interaction
Replies: 12
Views: 1470

Re: B12 and APOE4 - a gene-micronutrient interaction

Yikes: Higher plasma levels of B12 associated with a 25% increased risk of all-cause mortality. "Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands," Geriatrics (January 2020) doi:10.1001/jamanetworkopen.2019.19274 http...
by BrianR
Wed Jan 22, 2020 11:19 am
Forum: Science and Research
Topic: NAD+ homeostasis in health and disease
Replies: 0
Views: 123

NAD+ homeostasis in health and disease

Very detailed review of NAD+ for those who want to better understand this molecule. Open access at the URL, not sure if it's time limited. (The site discourages downloading of the open access version.) The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple m...
by BrianR
Tue Jan 14, 2020 5:39 pm
Forum: Science and Research
Topic: study: Tb vaccine lowers AD risk.
Replies: 11
Views: 806

Re: study: Tb vaccine lowers AD risk.

... I wonder if vaccinations for pneumonia would be wise for a precaution for 4s. ... FWIW, https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/infections-and-dementia asserts Which infections are thought to be linked to Alzheimer's disease? Some of the infections that are thou...

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