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by BrianR
Thu Mar 26, 2020 5:02 pm
Forum: Science and Research
Topic: Extensive review: mTOR at the nexus of nutrition, growth, ageing and disease
Replies: 1
Views: 156

Extensive review: mTOR at the nexus of nutrition, growth, ageing and disease

For those who are particularly interested in understanding the mTOR pathway, this open access version of a Nature Reviews article should be quite useful. https://www.nature.com/articles/s41580-019-0199-y.epdf?shared_access_token=DeQUy7mxUc7EQrB8xuJ24dRgN0jAjWel9jnR3ZoTv0MIveQk5wMRmbsVdfWnsqcR28iC3Jh...
by BrianR
Tue Mar 10, 2020 6:12 pm
Forum: Prevention and Treatment
Topic: High Homocysteine Possible Deficiencies
Replies: 10
Views: 654

Re: High Homocysteine Possible Deficiencies

Numerous medical journals have reported that taking doses of folate of 1 gram or more increase the chance of prostate cancer. Hmm, folate supplement or folic acid supplement? From https://www.cancer.gov/types/prostate/patient/prostate-prevention-pdq Folate is a kind of vitamin B that occurs natural...
by BrianR
Sun Mar 08, 2020 5:00 pm
Forum: Prevention and Treatment
Topic: rapamycin has harmful effects when telomeres are short
Replies: 0
Views: 106

rapamycin has harmful effects when telomeres are short

Interesting article/study. [Research done on "telomerase deficient mice". May or may not be relevant to aging humans.] Article: The CNIO discovers that rapamycin has harmful effects when telomeres are short https://www.eurekalert.org/pub_releases/2020-03/cndi-tcd022820.php Open access pape...
by BrianR
Thu Mar 05, 2020 4:10 pm
Forum: Science and Research
Topic: Alzheimer's: Can [l-serine] help restore memories?
Replies: 0
Views: 119

Alzheimer's: Can [l-serine] help restore memories?

Science Daily article: https://www.sciencedaily.com/releases/2020/03/200303113357.htm Research done in a mouse model of AD. The paywalled research paper is https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30063-2 Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contribut...
by BrianR
Thu Feb 06, 2020 4:58 pm
Forum: Prevention and Treatment
Topic: Trying to understand the Brain Blood Barrier
Replies: 3
Views: 258

Re: Trying to understand the Brain Blood Barrier

I've been on an asthma/allergy medication that's a leukotriene inhibitor, montelukast sodium aka Singulair for over a decade. Knowing that some asthma meds are now implicated in increased dementia risk due to being anticholinergic (benadryl, tiotropium bromide), I googled "singulair and dement...
by BrianR
Thu Feb 06, 2020 4:55 pm
Forum: Prevention and Treatment
Topic: Trying to understand the Brain Blood Barrier
Replies: 3
Views: 258

Re: Trying to understand the Brain Blood Barrier

Have you seen the Rhonda Patrick paper Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease in which she discusses [abstracting from the Abstract] "I propose that APOE4 carriers have impaired brain transport of free DHA but not of DHA-lysoPC, as a consequence of a ...
by BrianR
Thu Feb 06, 2020 4:50 pm
Forum: Prevention and Treatment
Topic: Two on Parkinson's Disease / APOE4 / Dementia, etc.
Replies: 1
Views: 212

Re: Two on Parkinson's Disease / APOE4 / Dementia, etc.

Link to the open access paper: https://stm.sciencemag.org/content/12/529/eaay3069 The work was done in a mouse model which had human variants for APOE (2/3/4), but the researchers did confirm their hypothesis to their satisfaction using a smallish study of human PD patients. The mice with APOE4 had ...
by BrianR
Wed Feb 05, 2020 9:45 am
Forum: Science and Research
Topic: AD Development May Be Thwarted by Certain Gene Variants [TREM2, ABCA7, SORL1, PSEN1 ... via PI3K/Akt/GSK-3β signaling pa
Replies: 0
Views: 200

AD Development May Be Thwarted by Certain Gene Variants [TREM2, ABCA7, SORL1, PSEN1 ... via PI3K/Akt/GSK-3β signaling pa

Interpretive article here: https://www.clinicalomics.com/topics/informatics-topic/alzheimers-disease-development-may-be-thwarted-by-certain-gene-variants/ An analysis of exome sequencing data from more than 10,000 individuals with late onset Alzheimer’s disease (AD; LOAD) suggests that natural varia...
by BrianR
Tue Feb 04, 2020 2:59 pm
Forum: Prevention and Treatment
Topic: Can Herpes Zoster ophthalmicus (Shingles) affect the Alzheimer's brain?
Replies: 17
Views: 1157

Re: Can Herpes Zoster ophthalmicus (Shingles) affect the Alzheimer's brain?

slacker wrote:There have been shortages of the vaccine in the US.

Just to note that the Shingrix shortage seemed to have cleared up last year. I was able to get the vaccinations in the late summer/early fall of last year (2019) on a walk-in basis.
by BrianR
Sat Jan 25, 2020 4:15 pm
Forum: Science and Research
Topic: Can lithium halt progression of Alzheimer's disease?
Replies: 1
Views: 260

Can lithium halt progression of Alzheimer's disease?

Research done in a transgenic rat model for AD using a special formulation/encapsulation of lithium demonstrated improved cognitive abilities and decreases in amyloid beta. Open access Science Daily discussion: https://www.sciencedaily.com/releases/2020/01/200125090727.htm Summary : In a new study, ...

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