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by BrianR
Sat Feb 20, 2021 11:24 am
Forum: Science and Research
Topic: A healthy brain at age 100 with ApoE 4!
Replies: 4
Views: 584

Re: A healthy brain at age 100 with ApoE 4!

If I remember correctly, there has been a study (or studies?) which suggests there are genetic mutations which tend to extend lifespan without much regard to APOE variant. I believe a particular allele of KLOTHO was particularly beneficial. Not, of course, very useful if one doesn't have that partic...
by BrianR
Sat Feb 13, 2021 1:10 pm
Forum: Science and Research
Topic: Podcast: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases
Replies: 1
Views: 348

Podcast: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases

I recently listened to this podcast: STEM-Talk Episode 118: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases and thought it was fairly interesting. Today we have part two of our conversation with Dr. Julie Andersen, a professor at the Buck Institute ...
by BrianR
Sat Feb 06, 2021 11:44 am
Forum: Science and Research
Topic: The silence of the fats.
Replies: 1
Views: 196

Re: The silence of the fats.

Interesting. " In parallel, a growing body of literature is bolstering the novel MAM hypothesis that postulates that abnormal accumulation of C99 at the MAM provokes aberrant ER-mitochondria communication, which triggers a cascade of events that lead to AD symptoms and features. " Open acc...
by BrianR
Tue Feb 02, 2021 5:39 pm
Forum: Science and Research
Topic: Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?
Replies: 0
Views: 106

Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

Open access: https://elifesciences.org/articles/65180 Gross ways to live long: Parasitic worms as an anti-inflammaging therapy? Bruce Zhang, David Gems. Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, United Kingdom Review Artic...
by BrianR
Sat Dec 26, 2020 9:57 am
Forum: Science and Research
Topic: Dr. Peter Attia podcast on Alzheimer’s disease prevention
Replies: 13
Views: 2012

Re: Dr. Peter Attia podcast on Alzheimer’s disease prevention

https://thewomensalzheimersmovement.org/8-steps-to-reverse-memory-loss-2-2-6/ Is this the guy? 2 mins in......Sherlocking skills required!!! I'm not familiar with a lot of the supplement branding over there but I'm very confident someone will have this identified fairly quickly ;) I'd say this vide...
by BrianR
Sat Dec 19, 2020 8:50 am
Forum: Science and Research
Topic: APOE4 associated with lower levels of inflammatory markers in CNS fluid?
Replies: 0
Views: 201

APOE4 associated with lower levels of inflammatory markers in CNS fluid?

The conclusion of this [paywalled] paper surprised me. I found an open access pre-print at https://www.medrxiv.org/content/10.1101/2020.06.30.20143578v1.full.pdf https://pubmed.ncbi.nlm.nih.gov/33337362/ APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid Miles Berger, et al. J ...
by BrianR
Sat Dec 19, 2020 8:11 am
Forum: Science and Research
Topic: The unmapped chemical complexity of our diet
Replies: 3
Views: 491

The unmapped chemical complexity of our diet

I found this open access discussion piece very interesting. https://www.nature.com/articles/s43016-019-0005-1 The unmapped chemical complexity of our diet. Albert-László Barabási, Giulia Menichetti & Joseph Loscalzo Nature Food volume 1, pages 33–37(2020) Abstract Our understanding of how diet a...
by BrianR
Sat Dec 19, 2020 7:55 am
Forum: Science and Research
Topic: Wine and Cheese Might Actually Help You Avoid Dementia
Replies: 3
Views: 545

Re: Wine and Cheese Might Actually Help You Avoid Dementia

Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study Behind a paywall, you'll need to use Sci-hub to look at it. The study used retrospective food consumption questionnaires. Which, of course, are known to have issues. APOE...
by BrianR
Sat Dec 12, 2020 8:47 am
Forum: Science and Research
Topic: Dr. Peter Attia podcast on Alzheimer’s disease prevention
Replies: 13
Views: 2012

Re: Dr. Peter Attia podcast on Alzheimer’s disease prevention

The podcast mentioned the Rosalynn Carter Institute programs for dementia caregivers: https://www.rosalynncarter.org/programs/dealing-with-dementia/ They offer two programs: ⋅ RCI REACH (Resources Enhancing Alzheimer’s Caregiver Health) provides one-on-one coaching, either in-person throug...
by BrianR
Fri Dec 04, 2020 4:48 pm
Forum: Science and Research
Topic: Hidden network of enzymes accounts for loss of brain synapses in Alzheimer's
Replies: 0
Views: 224

Hidden network of enzymes accounts for loss of brain synapses in Alzheimer's

Science Daily interpretation: https://www.sciencedaily.com/releases/2020/12/201204110234.htm A new study on Alzheimer's disease has revealed a previously unknown biochemical cascade in the brain that leads to the destruction of synapses, the connections between nerve cells that are responsible for m...

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