I've been on an asthma/allergy medication that's a leukotriene inhibitor, montelukast sodium aka Singulair for over a decade. Knowing that some asthma meds are now implicated in increased dementia risk due to being anticholinergic (benadryl, tiotropium bromide), I googled "singulair and dement...

Have you seen the Rhonda Patrick paper Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease in which she discusses [abstracting from the Abstract] "I propose that APOE4 carriers have impaired brain transport of free DHA but not of DHA-lysoPC, as a consequence of a ...

Link to the open access paper: https://stm.sciencemag.org/content/12/529/eaay3069 The work was done in a mouse model which had human variants for APOE (2/3/4), but the researchers did confirm their hypothesis to their satisfaction using a smallish study of human PD patients. The mice with APOE4 had ...

Interpretive article here: https://www.clinicalomics.com/topics/informatics-topic/alzheimers-disease-development-may-be-thwarted-by-certain-gene-variants/ An analysis of exome sequencing data from more than 10,000 individuals with late onset Alzheimer’s disease (AD; LOAD) suggests that natural varia...

slacker wrote:There have been shortages of the vaccine in the US.

Just to note that the Shingrix shortage seemed to have cleared up last year. I was able to get the vaccinations in the late summer/early fall of last year (2019) on a walk-in basis.

Research done in a transgenic rat model for AD using a special formulation/encapsulation of lithium demonstrated improved cognitive abilities and decreases in amyloid beta. Open access Science Daily discussion: https://www.sciencedaily.com/releases/2020/01/200125090727.htm Summary : In a new study, ...

https://www.nutraingredients-usa.com/Article/2020/01/21/Contract-manufacturer-recalls-products-under-more-than-1-200-brand-names?utm_source=copyright&utm_medium=OnSite&utm_campaign=copyright FDA recall notice: https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/abh-natures-p...

Yikes: Higher plasma levels of B12 associated with a 25% increased risk of all-cause mortality. "Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands," Geriatrics (January 2020) doi:10.1001/jamanetworkopen.2019.19274 http...

Very detailed review of NAD+ for those who want to better understand this molecule. Open access at the URL, not sure if it's time limited. (The site discourages downloading of the open access version.) The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple m...

... I wonder if vaccinations for pneumonia would be wise for a precaution for 4s. ... FWIW, https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/infections-and-dementia asserts Which infections are thought to be linked to Alzheimer's disease? Some of the infections that are thou...