Do you know what drug they were looking at? The paper is behind a paywall... I used SciHub to peek behind the paywall. Here are some extracts from the paper. Note their human cell work was apparently in vitro, so we'll have to see how their calcineurin inhibitors do in actual humans. (The inhibitor...

Mice expressing the human APOE4 allele exhibited reduced melanoma progression and metastasis relative to APOE2 mice. APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depletion experiments showed that the effect of APOE genotype on melanoma progression wa...

Alzheimer's Afternoons Seminar #14, May 12, Axel Montagne on Youtube Title: APOE4-associated vascular dysfunctions in both humans and animal models [With a focus in the Blood Brain Barrier] Speaker: Axel Montagne, PhD Institution: University of Southern California The tweet announcing this video sa...

Fiver wrote:I wrote up my notes from these recent online seminars, for friends and colleagues (many of whom who are not experts in the field). Pasted here in case anyone is interested.

Fiver, these notes are wonderful! Thank you so much.

Interesting results from the DIAN-TU trial, as reported in alzforum. In DIAN-TU, Gantenerumab Brings Down Tau. By a Lot. Open Extension Planned ... But all is not lost for gantenerumab, a monoclonal targeting aggregated forms of Aβ. Besides removing amyloid plaques from the brain and normalizing CSF...

Here is a full list of articles: APOE in Alzheimer's disease and neurodegeneration D. Allan Butterfield, Lance A. Johnson APOE in the normal brain Sarah A. Flowers, G. William Rebeck Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How Cutler T. Lew...

For those who are particularly interested in understanding the mTOR pathway, this open access version of a Nature Reviews article should be quite useful. https://www.nature.com/articles/s41580-019-0199-y.epdf?shared_access_token=DeQUy7mxUc7EQrB8xuJ24dRgN0jAjWel9jnR3ZoTv0MIveQk5wMRmbsVdfWnsqcR28iC3Jh...

Numerous medical journals have reported that taking doses of folate of 1 gram or more increase the chance of prostate cancer. Hmm, folate supplement or folic acid supplement? From https://www.cancer.gov/types/prostate/patient/prostate-prevention-pdq Folate is a kind of vitamin B that occurs natural...

Interesting article/study. [Research done on "telomerase deficient mice". May or may not be relevant to aging humans.] Article: The CNIO discovers that rapamycin has harmful effects when telomeres are short https://www.eurekalert.org/pub_releases/2020-03/cndi-tcd022820.php Open access pape...

Science Daily article: https://www.sciencedaily.com/releases/2020/03/200303113357.htm Research done in a mouse model of AD. The paywalled research paper is https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30063-2 Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contribut...