I ran across this podcast: https://amindr.com/ AMiNDR: A Month in Neurodegenerative Disease Research This is a podcast made by scientists for scientists, to help you save time so you can conduct better research. During each episode, the latest primary research articles in each topic for the past mon...

I thought this open access literature review was relatively readable (or at least, in my case, skimmable). https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00712-4 APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review....

I believe other studies have shown that supplementation with Folic Acid can increase cancer risk. However, supplementation with Folate does not.

This is an excellent podcast on the topic and how ketones can modulate the effect. The meat of the podcast on this topic starts around 57:00. (StemTalk Episode 114: Lilianne Mujica-Parodi talks about how diet and ketones affect brain aging) Thanks Tincup (and Fiver!). Tincup has referenced the Stem...

NF52 previously posted a link to a paper which discussed the rs9536314 G/T genetic variant which provides extra KLOTHO which seems to be associated with extra longevity, even for APOE4 carriers. https://www.apoe4.info/forums/viewtopic.php?f=16&t=6051&p=66186#p75153 While looking into this qu...

Open access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366647/ Multivariate genomic scan implicates novel loci and haem metabolism in human ageing Nat Commun. 2020; 11: 3570. Published online 2020 Jul 16. Paul R. H. J. Timmers [corresponding author], James F. Wilson, Peter K. Joshi [correspondin...

Iv`e heard that faster reaction speeds are associated with good brain health. Is there any strong evidence to support this theory? Iv`e been wondering if taking up one of the martial arts would help protect against alzheimers. I know that fast reaction times helps prevent falls, which is another th...

Can someone please explain a few things to me that I am struggling to get my head around... I know I need to take supplements to get choline as I can't get it from my diet. Which is best to take, choline or phosphatidyl choline? Chris Masterjohn has some useful information on this page: The Choline...

Open access preprint: https://www.biorxiv.org/content/10.1101/2020.10.19.345991v2 bioRxiv posted October 20, 2020. APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis Brandon C Farmer, ..., Lance A. Johnson doi: 10.1101/2020.10.19.345991 For th...

One of Ethan Weiss's lab team ran a study on Time Restricted Eating in humans . The primary focus was weight loss, but they also looked at potential metabolic benefits. The results did not indicate value for TRE and did find statistically significant loss of lean muscle mass in the TRE group. This i...