If I remember correctly, there has been a study (or studies?) which suggests there are genetic mutations which tend to extend lifespan without much regard to APOE variant. I believe a particular allele of KLOTHO was particularly beneficial. Not, of course, very useful if one doesn't have that partic...

I recently listened to this podcast: STEM-Talk Episode 118: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases and thought it was fairly interesting. Today we have part two of our conversation with Dr. Julie Andersen, a professor at the Buck Institute ...

Interesting. " In parallel, a growing body of literature is bolstering the novel MAM hypothesis that postulates that abnormal accumulation of C99 at the MAM provokes aberrant ER-mitochondria communication, which triggers a cascade of events that lead to AD symptoms and features. " Open acc...

Open access: https://elifesciences.org/articles/65180 Gross ways to live long: Parasitic worms as an anti-inflammaging therapy? Bruce Zhang, David Gems. Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, United Kingdom Review Artic...

https://thewomensalzheimersmovement.org/8-steps-to-reverse-memory-loss-2-2-6/ Is this the guy? 2 mins in......Sherlocking skills required!!! I'm not familiar with a lot of the supplement branding over there but I'm very confident someone will have this identified fairly quickly ;) I'd say this vide...

The conclusion of this [paywalled] paper surprised me. I found an open access pre-print at https://www.medrxiv.org/content/10.1101/2020.06.30.20143578v1.full.pdf https://pubmed.ncbi.nlm.nih.gov/33337362/ APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid Miles Berger, et al. J ...

I found this open access discussion piece very interesting. https://www.nature.com/articles/s43016-019-0005-1 The unmapped chemical complexity of our diet. Albert-László Barabási, Giulia Menichetti & Joseph Loscalzo Nature Food volume 1, pages 33–37(2020) Abstract Our understanding of how diet a...

Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study Behind a paywall, you'll need to use Sci-hub to look at it. The study used retrospective food consumption questionnaires. Which, of course, are known to have issues. APOE...

The podcast mentioned the Rosalynn Carter Institute programs for dementia caregivers: https://www.rosalynncarter.org/programs/dealing-with-dementia/ They offer two programs: ⋅ RCI REACH (Resources Enhancing Alzheimer’s Caregiver Health) provides one-on-one coaching, either in-person throug...

Science Daily interpretation: https://www.sciencedaily.com/releases/2020/12/201204110234.htm A new study on Alzheimer's disease has revealed a previously unknown biochemical cascade in the brain that leads to the destruction of synapses, the connections between nerve cells that are responsible for m...