For those who are particularly interested in understanding the mTOR pathway, this open access version of a Nature Reviews article should be quite useful. https://www.nature.com/articles/s41580-019-0199-y.epdf?shared_access_token=DeQUy7mxUc7EQrB8xuJ24dRgN0jAjWel9jnR3ZoTv0MIveQk5wMRmbsVdfWnsqcR28iC3Jh...

Numerous medical journals have reported that taking doses of folate of 1 gram or more increase the chance of prostate cancer. Hmm, folate supplement or folic acid supplement? From https://www.cancer.gov/types/prostate/patient/prostate-prevention-pdq Folate is a kind of vitamin B that occurs natural...

Interesting article/study. [Research done on "telomerase deficient mice". May or may not be relevant to aging humans.] Article: The CNIO discovers that rapamycin has harmful effects when telomeres are short https://www.eurekalert.org/pub_releases/2020-03/cndi-tcd022820.php Open access pape...

Science Daily article: https://www.sciencedaily.com/releases/2020/03/200303113357.htm Research done in a mouse model of AD. The paywalled research paper is https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30063-2 Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contribut...

I've been on an asthma/allergy medication that's a leukotriene inhibitor, montelukast sodium aka Singulair for over a decade. Knowing that some asthma meds are now implicated in increased dementia risk due to being anticholinergic (benadryl, tiotropium bromide), I googled "singulair and dement...

Have you seen the Rhonda Patrick paper Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease in which she discusses [abstracting from the Abstract] "I propose that APOE4 carriers have impaired brain transport of free DHA but not of DHA-lysoPC, as a consequence of a ...

Link to the open access paper: https://stm.sciencemag.org/content/12/529/eaay3069 The work was done in a mouse model which had human variants for APOE (2/3/4), but the researchers did confirm their hypothesis to their satisfaction using a smallish study of human PD patients. The mice with APOE4 had ...

Interpretive article here: https://www.clinicalomics.com/topics/informatics-topic/alzheimers-disease-development-may-be-thwarted-by-certain-gene-variants/ An analysis of exome sequencing data from more than 10,000 individuals with late onset Alzheimer’s disease (AD; LOAD) suggests that natural varia...

slacker wrote:There have been shortages of the vaccine in the US.

Just to note that the Shingrix shortage seemed to have cleared up last year. I was able to get the vaccinations in the late summer/early fall of last year (2019) on a walk-in basis.

Research done in a transgenic rat model for AD using a special formulation/encapsulation of lithium demonstrated improved cognitive abilities and decreases in amyloid beta. Open access Science Daily discussion: https://www.sciencedaily.com/releases/2020/01/200125090727.htm Summary : In a new study, ...