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by BrianR
Thu Apr 08, 2021 1:23 pm
Forum: Prevention and Treatment
Topic: Specialized pro-resolving mediators [SPM] ?
Replies: 0
Views: 64

Specialized pro-resolving mediators [SPM] ?

I was listening to this interesting STEM-Talk podcast with David LeMay in which he discusses how specialized pro-resolving mediators (SPMs) help resolve inflammation. Previously on APOE4, there have been some passing mentions of SPMs, as well as noting a prescribed exogenous SPM (Metagenics) mention...
by BrianR
Sat Apr 03, 2021 12:25 pm
Forum: Science and Research
Topic: Women accumulate Alzheimer's-related protein [Tau] faster
Replies: 3
Views: 265

Re: Women accumulate Alzheimer's-related protein [Tau] faster

floramaria wrote:...Hi BrianR, wondering if this result could be related to testosterone levels in women.
NF52 recently posted this in another thread concerning testosterone.:...

Interesting, and plausible, thanks!
by BrianR
Sat Mar 27, 2021 9:03 am
Forum: Science and Research
Topic: Women accumulate Alzheimer's-related protein [Tau] faster
Replies: 3
Views: 265

Women accumulate Alzheimer's-related protein [Tau] faster

ScienceDaily summary: https://www.sciencedaily.com/releases/2021/03/210325115423.htm The first protein to aggregate in Alzheimer's is beta-amyloid. Men and women are equally affected by the first disease stages, and the analysis did not show any differences in the accumulation of beta-amyloid. Memor...
by BrianR
Mon Mar 15, 2021 11:47 am
Forum: Science and Research
Topic: Lilly’s Alzheimer’s [donanemab] Data
Replies: 2
Views: 228

Lilly’s Alzheimer’s [donanemab] Data

Another anti-amyloid antibody study, another disappointingly ambiguous result. Here is Derek Lowe's take: https://blogs.sciencemag.org/pipeline/archives/2021/03/15/lillys-alzheimers-data I still don’t see how any of the effects seen in this trial translate into any real-world benefits. Even if they’...
by BrianR
Sat Mar 13, 2021 9:30 am
Forum: Announcements and Events
Topic: Free Webinar: Avoid Alzheimer’s and Live an Unforgettable Life Thursday March 11
Replies: 4
Views: 318

Re: Free Webinar: Avoid Alzheimer’s and Live an Unforgettable Life Thursday March 11

Probably you know this, but US Daylight Savings Time and British Summer Time start on different days, so the offset will be different for the next two weeks of March. I've found that https://www.timeanddate.com/worldclock/meeting.html is a good resource for planning multi time zone calls.
by BrianR
Thu Mar 04, 2021 11:00 am
Forum: The Social Hour
Topic: How do you not define yourself by your APOE4 status?
Replies: 3
Views: 898

Re: How do you not define yourself by your APOE4 status?

Floramaria said everything so well, but if you want an easy sound bite to remember: Genes are not destiny APOE4 does increase your risk for dementia, but you can find many life changes on this site which will not only lower your risk of dementia, but also lower the risk of many other poor health out...
by BrianR
Thu Mar 04, 2021 10:43 am
Forum: Science and Research
Topic: Study: why the APOE4 gene enhances Alzheimer’s risk; choline reverses
Replies: 1
Views: 373

Study: why the APOE4 gene enhances Alzheimer’s risk; choline reverses

Caveat: study done with yeast and brain cells in a dish. Explainer article: Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk https://picower.mit.edu/news/study-offers-explanation-why-apoe4-gene-enhances-alzheimers-risk The gene variant disrupts lipid metabolism, but in ce...
by BrianR
Sat Feb 20, 2021 11:24 am
Forum: Science and Research
Topic: A healthy brain at age 100 with ApoE 4!
Replies: 4
Views: 828

Re: A healthy brain at age 100 with ApoE 4!

If I remember correctly, there has been a study (or studies?) which suggests there are genetic mutations which tend to extend lifespan without much regard to APOE variant. I believe a particular allele of KLOTHO was particularly beneficial. Not, of course, very useful if one doesn't have that partic...
by BrianR
Sat Feb 13, 2021 1:10 pm
Forum: Science and Research
Topic: Podcast: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases
Replies: 1
Views: 438

Podcast: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases

I recently listened to this podcast: STEM-Talk Episode 118: Julie Andersen talks about urolithin-A’s potential to prevent and treat neurodegenerative diseases and thought it was fairly interesting. Today we have part two of our conversation with Dr. Julie Andersen, a professor at the Buck Institute ...
by BrianR
Sat Feb 06, 2021 11:44 am
Forum: Science and Research
Topic: The silence of the fats.
Replies: 1
Views: 278

Re: The silence of the fats.

Interesting. " In parallel, a growing body of literature is bolstering the novel MAM hypothesis that postulates that abnormal accumulation of C99 at the MAM provokes aberrant ER-mitochondria communication, which triggers a cascade of events that lead to AD symptoms and features. " Open acc...

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