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by frankiesfriend
Sat May 02, 2020 5:44 pm
Forum: Science and Research
Topic: Ca:Mg ratio may affect APOE phenotype
Replies: 0
Views: 380

Ca:Mg ratio may affect APOE phenotype

Two interesting papers in preprint in the Journal of Alzheimer’s Disease may be of interest to the APOE4 community: Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial Xiangzhu Zhua, Amy R. Borensteinb,∗, Yinan Zhengc, Wei Zhangc, Douglas L. Seidnerd, Re...
by frankiesfriend
Tue Dec 17, 2019 2:09 pm
Forum: Our Stories
Topic: Nocturia issues -- suggestions?
Replies: 10
Views: 1171

Re: Nocturia issues -- suggestions?

I was evaluated by a Urologist for nocturia, which was a source of frequent night time awakenings. I had made and brought to the appointment a pretty detailed record of what I drank, how much and when, and also how much and when I urinated - about a week's worth of data. Based on the amount voided, ...
by frankiesfriend
Tue Dec 17, 2019 1:46 pm
Forum: Prevention and Treatment
Topic: AD genes beside APOE
Replies: 1
Views: 427

Re: AD genes beside APOE

This paper In the Journal of Alzheimer's Disease describes other AD genetic risks that arise from genes that regulate proteins involved in cholesterol metabolism, amyloid processing and clearance, immune response, and nerve cell protective factors: J Alzheimers Dis. 2018;62(2):887-900. A Network of ...
by frankiesfriend
Wed Nov 13, 2019 4:03 pm
Forum: Prevention and Treatment
Topic: Tracking HRV
Replies: 1
Views: 435

Tracking HRV

Heart Rate Variability (HRV) is one indicator of both cardiovascular health and general health, a topic covered pretty well in the Wiki. Many of the wearables like Fitbit and the Oura ring track HRV as well as heart rate and other fitness parameters. I have an OUra ring, which tracks HRV only during...
by frankiesfriend
Mon Nov 11, 2019 1:29 pm
Forum: Prevention and Treatment
Topic: Choline Confusion
Replies: 13
Views: 1421

Re: Choline Confusion

I have been confused on this issue as well. I do want to lower my homocysteine from 9.8, but I have read that choline intake raised insulin resistance (appears to be an inconsistent result according the studies Julie cited), but also I think I have read that choline supplementation may raise cholest...
by frankiesfriend
Sun Nov 03, 2019 7:02 am
Forum: Prevention and Treatment
Topic: Sleep Tracker
Replies: 31
Views: 5915

Re: Sleep Tracker

I bought an Oura ring about a month before the polysomnography (PSG) study I underwent about three months ago. The PSG indicated I had mild sleep apnea during REM sleep, and ZERO deep sleep. My sleep doctor recommended a CPAP but did not seem to care about the deep sleep. When I pressed for more inf...
by frankiesfriend
Sat Oct 26, 2019 3:44 pm
Forum: Prevention and Treatment
Topic: Lithium for AD prevention?
Replies: 4
Views: 794

Lithium for AD prevention?

A new review paper in the Journal of Neurodegenerative Diseases recounts the familiar lifestyle recommendations of healthy diet, lower stress, exercise and sleep for lowering the risk of developing Alzheimer's, as well as treating early symptoms. Additionally, the authors cite lithium deficiency as ...
by frankiesfriend
Mon Oct 21, 2019 1:59 pm
Forum: Science and Research
Topic: New study - alcohol and dementia risk
Replies: 3
Views: 684

New study - alcohol and dementia risk

Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment JAMA Network Open, September 27, 2019 - Koch, Manja, et al. (Article is open to the public, but I could not get a hyperlink to work.) This study extracted data from the Gingko ...
by frankiesfriend
Sat Oct 19, 2019 6:30 am
Forum: Getting Started
Topic: Intermittent Fasting
Replies: 72
Views: 12742

Re: Intermittent Fasting

I have been doing 16:8 IF for several years, but I have been thinking for a long time that I should embark on longer fasts, as is recommended by many in this forum who have benefited as well as many in the functional medicine health podcast arena. My overall goal would be as a tune up of general hea...
by frankiesfriend
Sat Oct 05, 2019 11:56 am
Forum: Science and Research
Topic: Lifestyle changes may not help Apoe4s
Replies: 14
Views: 2052

Re: Lifestyle changes may not help Apoe4s

After spinal fusion surgery on my lower back six years ago, I developed neuropathic symptoms (deep, aching pain and parathesias in my legs and feet), which greatly impacted my stamina and mobility. My neurologist prescribed gabapentin for neuropathy, but offered no other treatment. I sought a second...

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