Search found 92 matches

by James
Sat Aug 18, 2018 3:27 pm
Forum: Science and Research
Topic: Ketones may not improve regional cerebral blood flow in E4
Replies: 22
Views: 8076

Ketones may not improve regional cerebral blood flow in E4

https://www.ncbi.nlm.nih.gov/pubmed/30006299 Exp Gerontol. 2018 Jul 10;111:118-121. doi: 10.1016/j.exger.2018.07.009. [Epub ahead of print] Changes in regional cerebral blood flow associated with a 45 day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disea...
by James
Sun Sep 24, 2017 5:27 pm
Forum: Announcements and Events
Topic: Midwestern Meet-up 2017
Replies: 79
Views: 32061

Re: Midwestern Meet-up 2017

I’m planning to go but it depends on when my wife finishes the marathon and how she feels. If the weather is as warm as it has been this past week then it will be a brutal race, but it is supposed to cool back down this week. If I make it it’ll probably be closer to noon.
by James
Sun Sep 17, 2017 7:20 pm
Forum: Announcements and Events
Topic: Midwestern Meet-up 2017
Replies: 79
Views: 32061

Re: Midwestern Meet-up 2017

I live in the western suburbs and can make it in to Chicago on the Metra fairly easily, and can drive elsewhere in the area of necessary. I’ll be downtown for the Chicago marathon Oct 8 (my wife is running). I’m not sure i’ll be able to stick around afterward though.
by James
Sun Feb 19, 2017 6:30 am
Forum: Science and Research
Topic: CSF Ferritin predicts cognitive decline in E4s
Replies: 115
Views: 45616

Re: CSF Ferritin predicts cognitive decline in E4s

I don't see the value of checking the serum ferritin level. It does not tell you the brain iron status. I agree that serum (plasma) ferritin says very little about CSF ferritin. The original paper does not provide actionable information for non-researchers - it simply adds CSF ferritin to the well-...
by James
Fri Feb 10, 2017 7:33 pm
Forum: Announcements and Events
Topic: Midwestern Meet-up 2017
Replies: 79
Views: 32061

Re: Midwestern Meet-up 2017

Hi Julie. I'm sure you remember me from the early days of the board. I still lurk a bit, debating on posting here and there but just seem to not do much of that anymore on most forums. Still, I'm around. I live in the far west Chicago suburbs and could easily do a Chicago area meetup. Keep me posted...
by James
Sat Jun 18, 2016 9:53 am
Forum: Prevention and Treatment
Topic: Postprandial lipemia vs. glycemia
Replies: 20
Views: 9678

Re: Postprandial lipemia vs. glycemia

Aye, there's the nub. I don't believe we have enough settled science to confidently answer this question. And there is the extra complexity of the still not well understood mitochondrial defects in e4s. Hence the thought experiment. At this point I'll sate myself with intellectual discussion and ot...
by James
Sat Jun 18, 2016 9:37 am
Forum: Prevention and Treatment
Topic: Postprandial lipemia vs. glycemia
Replies: 20
Views: 9678

Re: Postprandial lipemia vs. glycemia

To further complicate this issue... Fasting blood sugar seems to paradoxically run higher with a HFLC diet in spite of a lower intake of carbohydrates via physiological insulin resistance and the dawn phenomenon + low serum insulin. With a large fasting window, blood sugar would then be running at ...
by James
Sat Jun 18, 2016 9:27 am
Forum: Prevention and Treatment
Topic: Postprandial lipemia vs. glycemia
Replies: 20
Views: 9678

Re: Postprandial lipemia vs. glycemia

And here's another - Is the diet, that got me to weight loss/better health dance, the one I stick with or do I swap dance partners because another one is better for maintenance in the long run? Along similar lines -- Is the diet that effortlessly brought me into peak physical condition, which I can...
by James
Sat Jun 18, 2016 9:09 am
Forum: Prevention and Treatment
Topic: 1mo of 24hr CGM data streaming
Replies: 27
Views: 10918

Re: 1mo of 24hr CGM data streaming

When the results aren't clear, I can re-run the same foods with permutations on the variables until I see some sort of trend. I probably won't get as much out of it as I'm hoping, but maybe a few interesting things or tricks will be gleaned. I imagine many interesting things will come from this. It...
by James
Tue Jun 14, 2016 8:03 am
Forum: Prevention and Treatment
Topic: Postprandial lipemia vs. glycemia
Replies: 20
Views: 9678

Postprandial lipemia vs. glycemia

Thought experiment: Assuming a mostly whole-foods diet with what we might assume are the best possible macronutrient sources, and assuming weight maintenance at a healthy/low-normal body weight, would it be better to follow a very low fat diet, a very low carb diet (possibly ketogenic), or a mixed d...