Surprised at some of the high Omega-3 Indexes with relatively moderate doses. I’m guessing you’re also eating a lot of fish and/or have a low BMI.

I’m interested in seeing what everyone’s daily supplemental Omega-3 dose is (EPA and DHA). And if you happen to know your Omega-3 Index?

I’m currently taking 3g EPA + 1g DHA.

If they used A as the reference allele, then G would be considered higher risk. The math is the same, just reversed.

And btw, AG is very common.

The meta-analysis shows a 38% risk reduction, but again I’m not sure if it’s AA vs GG or AA+AG vs GG. Either way, that’s quite a lot for a single SNP. rs157580 is in weak linkage disequilibrium with APOE e4. I inherited APOE e4 from my mother, but not her G allele.

Depends how you look at it. One could say each G increases risk.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727495/

I’m not sure exactly how the risk is stratified by genotype, but the A is protective.

Probably not much, if at all. rs157580 is the TOMM40 SNP that is significantly associated.

Usually a package deal, along with rs4420638.

Appreciate it, J11

Unfortunately, neither 23andMe v4 nor Ancestry v2 genotyped the two new ones with large ORs (SORT1, NCK2).

Anyone have access to the SNPs?