Thanks for the detailed info! I did see since my last post that the "12X risk" study suffered from some serious flaws, and the newer estimates of likelihood and age of onset are much more heartening. I'm already feeling much more optimistic about everything. I am still struggling with whet...

Wow, so it sounds like 4/4 is indeed quite rare. Since my first post I have read a bit more about expected progress in therapies, and you're right, it is very encouraging! Thanks for the responses.

Hello, I learned recently from genetic testing that I may be E4/E4, and I had a few questions. It's been a bit rough to process and there's so much conflicting information out there, so I was very happy to find this community - folks here seem to be very knowledgable and supportive, which is great. ...