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by Michae_M
Sun Sep 01, 2019 6:29 pm
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 3025

Re: Epigenetics - can we really turn APOE4 off?

One would not want to "turn off" APOE4 or any other APOE type. However, one might be able to correct its function with a small molecule. This is very promising: Treating apoE4 neurons with a small-molecule structure corrector ameliorated the detrimental effects, providing a proof of concep...
by Michae_M
Sun Sep 01, 2019 6:22 pm
Forum: Prevention and Treatment
Topic: General Anesthesia & ApoE4
Replies: 61
Views: 12039

Re: General Anesthesia & ApoE4

I would have her seek a second and third opinion on ECT and would want to see a 3/3 agreement on it's need before I would consider proceeding. That is a lot of stress on a 70 year old person. Too many unknowns here.
by Michae_M
Sun Sep 01, 2019 6:14 pm
Forum: Prevention and Treatment
Topic: Gundry internet ads
Replies: 66
Views: 6184

Re: Gundry internet ads

I would echo that on many levels, fasting might be the key to healthy, measurable, and effective weight loss in many people. Have you thought about fasting for longer periods?
by Michae_M
Sun Sep 01, 2019 1:56 pm
Forum: Science and Research
Topic: Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease
Replies: 0
Views: 291

Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease

Here is a wonderful paper that suggests a mechanism for the protective effects of fasting with respect to Adult Hippocampal Neurogenesis-The hunger hormone Ghrelin. Highlights There is a close relationship between cognitive performance and nutritional status, but the mechanisms underlying this relat...
by Michae_M
Sun Sep 01, 2019 10:15 am
Forum: Prevention and Treatment
Topic: Creatine increase in PCC in early AD
Replies: 5
Views: 595

Re: Creatine increase in PCC in early AD

On balance, I would not think that these complicated imaging studies should be viewed to suggested cause and effect. Here are two papers on the topic of creatine that you may find helpful. https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z https://www.sciencedirect.com/science/articl...
by Michae_M
Sun Sep 01, 2019 9:51 am
Forum: Science and Research
Topic: Exercise-Very Encouraging Study. What is your Exercise Prescription?
Replies: 21
Views: 3153

Re: Exercise-Very Encouraging Study. What is your Exercise Prescription?

Thank you for your many inspiring responses.

I hope all of you have had a wonderful summer and have had a chance to enjoy your many inspiring workout efforts.

Best wishes to all of you and let keep going this fall.

Michael_M
by Michae_M
Sun Jun 30, 2019 9:28 am
Forum: Science and Research
Topic: More info on why APOe4 may be worse for women-And what you can do about it.
Replies: 2
Views: 536

More info on why APOe4 may be worse for women-And what you can do about it.

Make sure you are getting ample amounts of DHA.. Our findings show a strong association between age, female sex, and an APOE4 genotype, with decreased cortical DHA and a number of SPMs, which together may contribute to the development of cognitive decline and AD pathology. https://www.ncbi.nlm.nih.g...
by Michae_M
Tue Jun 25, 2019 7:35 am
Forum: Science and Research
Topic: Anticholinergic Drug Exposure and the Risk of Dementia
Replies: 1
Views: 386

Re: Anticholinergic Drug Exposure and the Risk of Dementia

Brian-I just saw this and posted a link just after you did not seeing your post. The concerning thing is as little as "3 years’ daily use of a single strong anticholinergic medication at the minimum effective dose recommended for older people" may increase the risk of dementia by nearly 50...
by Michae_M
Tue Jun 25, 2019 7:31 am
Forum: Science and Research
Topic: Further caution on the use of routine anticholinergics.
Replies: 0
Views: 326

Further caution on the use of routine anticholinergics.

Caution: As little as "3 years’ daily use of a single strong anticholinergic medication at the minimum effective dose recommended for older people" may increase the risk of dementia by nearly 50%. Researchers "indicate that around 10% of dementia diagnoses are attributable to antichol...
by Michae_M
Tue Jun 25, 2019 7:28 am
Forum: Science and Research
Topic: More Good News! Dementia can be delayed and MCI reversed!
Replies: 0
Views: 387

More Good News! Dementia can be delayed and MCI reversed!

Additional researchers assert after a recent review of the literature: Based on our survey of current literature and findings, we cautiously conclude that healthy diets, regular exercise, and improved lifestyle can delay dementia progression and reduce the risk of AD in elderly individuals and rever...

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