One would not want to "turn off" APOE4 or any other APOE type. However, one might be able to correct its function with a small molecule. This is very promising: Treating apoE4 neurons with a small-molecule structure corrector ameliorated the detrimental effects, providing a proof of concep...

I would have her seek a second and third opinion on ECT and would want to see a 3/3 agreement on it's need before I would consider proceeding. That is a lot of stress on a 70 year old person. Too many unknowns here.

I would echo that on many levels, fasting might be the key to healthy, measurable, and effective weight loss in many people. Have you thought about fasting for longer periods?

Here is a wonderful paper that suggests a mechanism for the protective effects of fasting with respect to Adult Hippocampal Neurogenesis-The hunger hormone Ghrelin. Highlights There is a close relationship between cognitive performance and nutritional status, but the mechanisms underlying this relat...

On balance, I would not think that these complicated imaging studies should be viewed to suggested cause and effect. Here are two papers on the topic of creatine that you may find helpful. https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z https://www.sciencedirect.com/science/articl...

Thank you for your many inspiring responses.

I hope all of you have had a wonderful summer and have had a chance to enjoy your many inspiring workout efforts.

Best wishes to all of you and let keep going this fall.

Michael_M

Make sure you are getting ample amounts of DHA.. Our findings show a strong association between age, female sex, and an APOE4 genotype, with decreased cortical DHA and a number of SPMs, which together may contribute to the development of cognitive decline and AD pathology. https://www.ncbi.nlm.nih.g...

Brian-I just saw this and posted a link just after you did not seeing your post. The concerning thing is as little as "3 years’ daily use of a single strong anticholinergic medication at the minimum effective dose recommended for older people" may increase the risk of dementia by nearly 50...

Caution: As little as "3 years’ daily use of a single strong anticholinergic medication at the minimum effective dose recommended for older people" may increase the risk of dementia by nearly 50%. Researchers "indicate that around 10% of dementia diagnoses are attributable to antichol...

Additional researchers assert after a recent review of the literature: Based on our survey of current literature and findings, we cautiously conclude that healthy diets, regular exercise, and improved lifestyle can delay dementia progression and reduce the risk of AD in elderly individuals and rever...