Search found 50 matches

by PhillyFree
Wed Jun 01, 2016 10:28 pm
Forum: Science and Research
Topic: CHAT (acetylcholine transferase) gene and AD risk
Replies: 19
Views: 7733

CHAT (acetylcholine transferase) gene and AD risk

CHAT gene (acetylcholine transferase) on Chr. 10 encodes an enzyme for synthesizing acetylcholine. http://www.genecards.org/cgi-bin/carddisp.pl?gene=CHAT Keeping acetylcholine in the system longer is a goal of the cholinesterase inhibitor type of Alzheimers meds such as Aricept. CHAT gene mutations ...
by PhillyFree
Fri Apr 01, 2016 2:25 pm
Forum: Science and Research
Topic: Folic Acid inhibits Amyloid-beta ....
Replies: 12
Views: 5434

Folic Acid inhibits Amyloid-beta ....

Folic Acid inhibits Amyloid-beta ..... [Lu, Liu, Yu, et al, 2016] http://www.ncbi.nlm.nih.gov/pubmed/25959374 ------------- Comments: Those who need the folate form could use that instead. Anyone can use the folate form (e.g. Solgar Folate from Metafolin), but persons with wildtype MTHFR genetics ma...
by PhillyFree
Thu Mar 03, 2016 2:37 pm
Forum: Prevention and Treatment
Topic: E3/4 rarely seen in centenarians
Replies: 6
Views: 3042

E3/4 rarely seen in centenarians

E3/4 genotype is rarely seen in centenarians. E2, E2/3 enriched in centenarians, who also tend to have lower LDL-C. https://www.genomeweb.com/sequencing-technology/apoe-sequencing-confirms-previous-markers-longevity-implicates-regulatory [Ryu, Atzmon, et al, 2016] http://www.sciencedirect.com/scienc...
by PhillyFree
Fri Aug 07, 2015 1:10 pm
Forum: Science and Research
Topic: Microglia - cops on the beat that clear amyloid beta
Replies: 3
Views: 2328

Re: Microglia - cops on the beat that clear amyloid beta

More on the role of microglia in relation to AD

[ElAli, Rivest, Aug 2015 - see Highlights]
http://www.sciencedirect.com/science/ar ... 911500416X
by PhillyFree
Sun Aug 02, 2015 12:58 am
Forum: Science and Research
Topic: Fisetin in some fruits and veg can help memory
Replies: 1
Views: 1640

Fisetin in some fruits and veg can help memory

Fisetin in some fruits and veg may protect against memory loss / Alz / AD
http://www.alzheimers.net/2014-04-01/be ... lzheimers/


[Currais, Prior, et al, 2014]
http://www.ncbi.nlm.nih.gov/pubmed/24341874
full article available free
by PhillyFree
Sat Jul 25, 2015 12:09 am
Forum: Science and Research
Topic: Poor sleep linked to toxic buildup of Alzheimer's protein, memory loss
Replies: 6
Views: 3507

Re: Poor sleep linked to toxic buildup of Alzheimer's protein, memory loss

Poor sleep raises cortisol, which in turn raises glucose. We know that insulin resistance and diabetes 2 raise risk of AD. So many people over age 50 and/or if obese are insulin resistant and don't know it, since most doctors don't pay much attention until the person comes down with diabetes 2, then...
by PhillyFree
Sat Jul 25, 2015 12:05 am
Forum: Science and Research
Topic: Who owns the AD research? UCSD vs. USC
Replies: 0
Views: 1166

Who owns the AD research? UCSD vs. USC

Who owns the AD research? UCSD or USC?

How the problem unfolded:
http://www.latimes.com/local/california ... story.html
by PhillyFree
Sun Jun 14, 2015 12:48 am
Forum: Science and Research
Topic: AD as systemic
Replies: 4
Views: 2945

AD as systemic

On AD as systemic, with biomarkers

[Gonzalez-Dominguez, et al, 2015]
http://pubs.rsc.org/en/content/articlel ... ivAbstract
by PhillyFree
Wed Mar 18, 2015 8:02 pm
Forum: Prevention and Treatment
Topic: 'Strongest Evidence Yet' Links Anticholinergic Drugs, Dementia
Replies: 57
Views: 26090

Re: 'Strongest Evidence Yet' Links Anticholinergic Drugs, Dementia

PEMT rs7946=TT here (along with 56% of others with Euro ancestry)

I've been aware of choline to offset risk of fatty liver for a few years now.

So I eat 3 eggs about every other day,
and use 1 scoop of Solgar brand (non-GMO soy) Lecithin in my morning smoothie.