... I'd been excited about therapies related to cyclophilin-A antagonist molecules after having read the third article listed. However, the first two suggest ...

Rhonda Patrick did an interview with Axel Montagne about blood-brain barrier repair in Episode ... episode, Montagne describes how epithelial activation through proteins like MMP9 and cyclophilin A degrades tight junctions in the BBB, leading to pericyte loss and neuron death. ...

Hi Brian, I saw this yesterday as well. This is a large paper, very thorough, with big effect sizes. Debio-025 really did seem to fix BBB and blood flow problems AND prevent the worsening of cognitive problems in these mice carrying ...

[There are a few previous APOE4 forum posts discussing Cyclophilin A's actions in the brain.] Science Daily explainer: https://www.sciencedaily.com/releases/2021/06/210614131220.htm ...

... very succinctly expresses the essence of the current leading theory of AD. "ApoE is known to exhibit isoform-specific effects on blood-brain ... susceptibility to injury by activating the proinflammatory cytokine cyclophilin A in pericytes and triggering the NF-kB/matrix metalloprotinase ...

... very succinctly expresses the essence of the current leading theory of AD. "ApoE is known to exhibit isoform-specific effects on blood-brain ... susceptibility to injury by activating the proinflammatory cytokine cyclophilin A in pericytes and triggering the NF-kB/matrix metalloprotinase ...

New member here. I haven't been able to access the exact paper that Julie G cites above is very impressive, ... deficits. We also found that rapamycin restored the levels of the proinflammatory cyclophilin A in vasculature, which may contribute to the preservation of cerebrovascular ...

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic ... deficits. We also found that rapamycin restored the levels of the proinflammatory cyclophilin A in vasculature, which may contribute to the preservation of cerebrovascular ...

Deciphering the mechanism that underlies the development of Alzheimer's disease in certain families but not ... Based on this discovery, they identified that the malfunction of the protein "cyclophilin B," which helps nascent proteins to attain their proper spatial structures, ...

At first glance this new paper seems to offer another reason to make aerobic an important part of your ... Apoe deficiency, APOE4 transgene in mice induces the activation of the proinflammatory cyclophilin A (CypA)–matrix metalloproteinase 9 (MMP-9) pathway in brain pericytes, leading ...