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Search found 312 matches: mtor

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by DistinguishedHeathen
Tue Sep 29, 2020 8:24 pm
Forum: Prevention and Treatment
Topic: Feeling intimidated: Q's re: diet & inflammation markers
Replies: 8
Views: 703

Re: Feeling intimidated: Q's re: diet & inflammation markers

... to look at his list to be sure, they also change the formulation over time. Gundry limits meat because of methionine, which stimulates Igf-1 & mTOR. Also because of Neu5Gc, which is controversial. Big thing is that 4's tend to react to sat fat, from a heart disease perspective. May not be an ...
by Tincup
Tue Sep 29, 2020 8:11 pm
Forum: Prevention and Treatment
Topic: Feeling intimidated: Q's re: diet & inflammation markers
Replies: 8
Views: 703

Re: Feeling intimidated: Q's re: diet & inflammation markers

... to look at his list to be sure, they also change the formulation over time. Gundry limits meat because of methionine, which stimulates Igf-1 & mTOR. Also because of Neu5Gc, which is controversial. Big thing is that 4's tend to react to sat fat, from a heart disease perspective. May not be an ...
by Newtothis3/4
Mon Aug 31, 2020 8:21 pm
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 8945

Re: Using RAPA for AD prevention

I decided not to take rapamycin ... mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR rhythms of the body (lower – though not ...
by circular
Fri Aug 14, 2020 4:06 pm
Forum: Prevention and Treatment
Topic: Dr. Bredesen interviews Julie G
Replies: 12
Views: 1480

Re: Dr. Bredesen interviews Julie G

... -- at lower cost -- but haven't had time to investigate these questions, and I wonder if anyone researched it. I also wonder, since increasing MTOR is one of the benefits, whether it is triggering the other benefits or a more downstream effect. If MTOR is an initiator of the other biochemical ...
by apod
Tue Aug 04, 2020 12:49 pm
Forum: Science and Research
Topic: Glucosamine: a mTOR inhibitor and autophagy activator?
Replies: 2
Views: 572

Re: Glucosamine: a mTOR inhibitor and autophagy activator?

... injury mimicking autoimmune hepatitis" https://pubmed.ncbi.nlm.nih.gov/23391366/ I don't have too much concern over glucosamine decreasing mTOR to a dangerous level -- it's a pretty common supplement in the athletic community with no apparent decrease in the ability to increase strength, ...
by circular
Mon Aug 03, 2020 1:12 pm
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 8945

Re: Using RAPA for AD prevention

... think I see that when you say 'crank up anabolism all the time' and 'incessant stimulus to produce more protein' you just mean relative to chronic MTOR inhibition. So what to me isn't incessant would be from that angle. And are you likening the anabolic resistance to MTOR1 to the anabolic resistance ...
by MichaelR
Mon Aug 03, 2020 10:32 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 8945

Re: Using RAPA for AD prevention

I decided not to take rapamycin ... mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR rhythms of the body (lower – though not ...
by circular
Sun Aug 02, 2020 2:38 pm
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 8945

Re: Using RAPA for AD prevention

I decided not to take rapamycin ... mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR rhythms of the body (lower – though not ...
by MichaelR
Sat Aug 01, 2020 4:13 pm
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 8945

Re: Using RAPA for AD prevention

... not a lifespan benefit, and not prevention of AD. And despite all the knowledge they gained through three clinical trials, their own short-acting mTOR inhibitor (BEZ235/RTB101) failed in Phase III , which says a lot about how hard it is to game this all out. Now: the main reason I came here to ...
by circular
Wed Jul 29, 2020 9:33 pm
Forum: Science and Research
Topic: Glucosamine: a mTOR inhibitor and autophagy activator?
Replies: 2
Views: 572

Re: Glucosamine: a mTOR inhibitor and autophagy activator?

What do you think? This is just a fly-by response since I'm off to bed, but since I think it's important to cycle MTOR/autophagy, I wondered what the half life of glucosamine is. It appears that in crystalline glucosamine sulfate it might quite chronically suppress MTOR. I don't ...

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