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by cdamaden
Thu Oct 10, 2019 1:59 pm
Forum: Science and Research
Topic: New paper implicating microglia in AD
Replies: 10
Views: 2329

Re: New paper implicating microglia in AD

and also providing a possible way to prevent the disease, [b]even in ApoE4 individuals! Thanks, Boiller, This paper from 2018 suggests there are herbal methods that could be followed to prevent "excessive microglial activation": https://www.hindawi.com/journals/jir/2018/9348046/ I've rece...
by cdamaden
Mon Sep 30, 2019 9:43 am
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 5818

Re: Epigenetics - can we really turn APOE4 off?

Thank you, LG1. I am on Dr. Patrick's email list so this was a good reminder to read up on her summary. I was able to select a product. Chris Chris, I believe Masterjohn recommends a micronized version such as this one: https://revgenetics.co.uk/collections/micronized-resveratrol/products/m98-bulk-m...
by cdamaden
Fri Sep 27, 2019 1:10 pm
Forum: Prevention and Treatment
Topic: Epigenetics - can we really turn APOE4 off?
Replies: 30
Views: 5818

Re: Epigenetics - can we really turn APOE4 off?

I'm interested in taking higher dose resveratrol as mentioned in the Attia/Sinclair interview. I looked at my traditional supplement brands of Jarrow and Pure Encapsulations but neither had anything that would give me a manageable number of pills to achieve a dose in the 500-1,000 mg range. There ar...
by cdamaden
Wed Sep 25, 2019 11:18 am
Forum: Prevention and Treatment
Topic: need for help about lab results
Replies: 26
Views: 4433

Re: need for help about lab results

Chris Masterjohn revised his recommendation earlier this year https://chrismasterjohnphd.com/blog/2019/02/26/mthfr-just-riboflavin-deficiency/ on lowering homocysteine to include more focus on vitamin B2/riboflavin (although a dose of 3-5mg/day doesn't seem like much when many supplements have 50mg)...
by cdamaden
Wed Sep 18, 2019 9:10 am
Forum: Science and Research
Topic: Pupillary dilation responses as a midlife indicator of risk for Alzheimer’s Disease: Association with AD
Replies: 1
Views: 550

Pupillary dilation responses as a midlife indicator of risk for Alzheimer’s Disease: Association with AD

Results held up after controlling for APOE genotype. Results support pupillary response—and by inference, LC dysfunction—as a genetically-mediated biomarker of early MCI/AD risk. In combination with other biomarkers, task-evoked pupillary responses may provide additional information for early screen...
by cdamaden
Thu Sep 12, 2019 1:51 pm
Forum: Science and Research
Topic: Markers associated with genetic resililience to AD in E4/E4's
Replies: 8
Views: 1566

Re: Markers associated with genetic resililience to AD in E4/E4's

They found 2 SNP's that seemed to have "strong evidence" for resilience (CASP7 rs10553596 and SERPINA3 rs4934-A/A). Thanks for posting broiler, I checked on my Promethease results (from my 23&me data), and it didn't have the CASP7 one and for the SERPINA3 it states: "rs4934 incre...
by cdamaden
Mon Sep 09, 2019 4:56 pm
Forum: Prevention and Treatment
Topic: List of dairy that's non-inflammatory
Replies: 11
Views: 2112

Re: List of dairy that's non-inflammatory

A note on that last point. I remember a Peter Attia podcast episode with Rhonda Patrick where they talk about saturated fat intake on a keto diet. In their own clinical experience, roughly 15% or so of their patients responded in a way that greatly increased their LDL-p (Low-Density-Cholesterol Lip...
by cdamaden
Wed Aug 21, 2019 2:53 pm
Forum: Science and Research
Topic: Sleep as a potential biomarker of tau and β-amyloid burden in the human brain
Replies: 6
Views: 1636

Re: Sleep as a potential biomarker of tau and β-amyloid burden in the human brain

Does anyone wear a fitbit? if so, how much DEEP sleep do you get each night? J. I recently bought an Oura ring and have been comparing it to my Fitbit. I haven't done a full excel spreadsheet comparison, but over the last five nights they show my deep sleep as: Saturday 31 min (FB) 80 min (O), rati...
by cdamaden
Fri Jul 19, 2019 12:05 pm
Forum: Science and Research
Topic: Does Alzheimer's Disease Stem From Infection?
Replies: 6
Views: 1809

Does Alzheimer's Disease Stem From Infection?

Scientists debate, and one company targets gingivitis bacterium to slow Alzheimer's progression https://www.medpagetoday.com/meetingcoverage/aaic/81065?xid=nl_mpt_DHE_2019-07-18&eun=g1321960d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%202019-07-18&utm_t...

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