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by aphorist
Mon Dec 30, 2019 8:55 am
Forum: Prevention and Treatment
Topic: Methylene Blue AD Cure Celebration Thread!
Replies: 34
Views: 7359

Re: Methylene Blue AD Cure Celebration Thread!

I am a believer in Methylene Blue. The mechanism of action makes tons of sense to me. My biggest problem with it is the mess it makes everywhere. If you showed me pharmaceutical grade pills in the proper dose that don't make a damn mess everywhere, I would probably take it. My whole kitchen is a blu...
by aphorist
Sat Dec 28, 2019 7:06 pm
Forum: Science and Research
Topic: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Replies: 5
Views: 1293

Re: Peter Attia #85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health

I went through the call and notes last night. It was pretty good. I'm going to modify my own exercise regimen around this Zone 2 conditioning framework. The explanations of how lactate works in the body (and its role in cancer) were superb. The discussion really connected a lot of metabolic pathways...
by aphorist
Wed Oct 23, 2019 12:06 pm
Forum: Our Stories
Topic: Any danger in sharing APOE e4/e4 status
Replies: 7
Views: 1524

Re: Any danger in sharing APOE e4/e4 status

IMO:

Healthcare Provider = OK.
Anyone else not bound by HIPAA or a duty of confidentiality (NDA, etc.) = No.
by aphorist
Wed Oct 09, 2019 3:27 pm
Forum: Science and Research
Topic: Other factors may override E4 inverse association with longevity
Replies: 2
Views: 809

Re: Other factors may override E4 inverse association with longevity

Interesting. I have a real hard time putting any stock in Table 3. Non-significant confidence intervals. ApoE4 Men who physically exercise having 3.26x the hazard incidence rate than those who are sedentary. Can't simultaneously suggest that low HDL is a biomarker for mortality and that exercising w...
by aphorist
Tue Oct 08, 2019 8:50 am
Forum: Prevention and Treatment
Topic: Glucose Ketone Index
Replies: 11
Views: 1854

Re: Glucose Ketone Index

stuff I meant a shift in terms of current utilization of metabolic substrates at that very moment. Not adaptation. You are clearly well adapted. Presumably if a person is not in diabetic ketoacidosis and their ketones are anything north of 2 mM, their metabolism has undergone this metabolic shift a...
by aphorist
Tue Oct 08, 2019 7:13 am
Forum: Prevention and Treatment
Topic: Glucose Ketone Index
Replies: 11
Views: 1854

Re: Glucose Ketone Index

If you tested the average person their GKI is probably infinite because their BHB is 0. I don't think Seyfried would distinguish between 0.9 and 1.1. There is likely a difference between 1, 5, 50, 500 & infinity. For example, glucose of 80 and ketones of 0.5 would be a GKI of ((80/18)/.05)=8.9 ...
by aphorist
Tue Oct 08, 2019 7:10 am
Forum: Prevention and Treatment
Topic: Glucose Ketone Index
Replies: 11
Views: 1854

Re: Glucose Ketone Index

I would disagree with this a bit. The value of one is where ketones = glucose. Getting ketones > glucose means GKI < 1. The body will use glucose before ketones if it has a choice (mostly to clear it), so to get to a point where your body is properly using ketones, you want to starve the body of gl...
by aphorist
Thu Oct 03, 2019 7:08 am
Forum: Prevention and Treatment
Topic: Glucose Ketone Index
Replies: 11
Views: 1854

Re: Glucose Ketone Index

It's just a simple ratio that some person can claim they 'invented' or that they are some 'pioneer' in identifying. Assuming you are not in diabetic ketoacidosis or taking exogenous ketones, what matters most is the absolute level of ketones, such that they are available as an energy substrate and y...
by aphorist
Tue Oct 01, 2019 5:56 am
Forum: Science and Research
Topic: apoe4 children have lower IQ`s ?
Replies: 29
Views: 5138

Re: apoe4 children have lower IQ`s ?

del

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